公开(公告)号：US20220119537A1

公开(公告)日：2022-04-21

申请号：US17339301

申请日：2021-06-04

Applicant: Amgen Inc.

Inventor： Dirk E. SMITH ,  Ian FOLTZ ,  Chadwick T. KING ,  Ai Ching LIM ,  Rutilio CLARK ,  Michael R. COMEAU ,  Randal R. KETCHEM ,  Donghui SHI ,  Xiaoshan MIN ,  Zhulun WANG

IPC: C07K16/28 ,  C07K16/24

Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.

公开(公告)号：US20210340270A1

公开(公告)日：2021-11-04

申请号：US17320128

申请日：2021-05-13

Applicant: Amgen Inc.

Inventor： Brian D. BENNETT ,  Chadwick T. KING ,  Jonathan PHILLIPS

IPC: C07K16/28 ,  A61K39/395 ,  C07K16/22 ,  A61P37/00

Abstract: Methods of treating conditions related to lung disease using an antigen binding protein specific for the Jagged1 polypeptide are provided.

公开(公告)号：US20150376286A1

公开(公告)日：2015-12-31

申请号：US14752493

申请日：2015-06-26

Applicant: AMGEN INC.

Inventor： Thomas C. BOONE ,  David W. BRANKOW ,  Colin V. GEGG, JR. ,  Shaw-Fen Sylvia HU ,  Chadwick T. KING ,  Hsieng Sen LU ,  Licheng SHI ,  Cen XU

IPC: C07K16/28

CPC classification number: C07K16/2869 ,  A61K39/395 ,  A61K39/39533 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/32 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

Abstract: Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.

Abstract translation: 提供了结合人CGRP受体（CGRP R）的抗原结合蛋白。 还提供编码抗原结合蛋白，载体和编码抗原结合蛋白的核酸的核酸。 抗原结合蛋白可以抑制CGRP R与CGRP的结合，并且可用于多种CGRP R相关疾病，包括治疗和/或预防偏头痛。