公开(公告)号：US20150376286A1

公开(公告)日：2015-12-31

申请号：US14752493

申请日：2015-06-26

Applicant: AMGEN INC.

Inventor： Thomas C. BOONE ,  David W. BRANKOW ,  Colin V. GEGG, JR. ,  Shaw-Fen Sylvia HU ,  Chadwick T. KING ,  Hsieng Sen LU ,  Licheng SHI ,  Cen XU

IPC: C07K16/28

CPC classification number: C07K16/2869 ,  A61K39/395 ,  A61K39/39533 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/32 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

Abstract: Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.

Abstract translation: 提供了结合人CGRP受体（CGRP R）的抗原结合蛋白。 还提供编码抗原结合蛋白，载体和编码抗原结合蛋白的核酸的核酸。 抗原结合蛋白可以抑制CGRP R与CGRP的结合，并且可用于多种CGRP R相关疾病，包括治疗和/或预防偏头痛。

公开(公告)号：US20210179722A1

公开(公告)日：2021-06-17

申请号：US17111442

申请日：2020-12-03

Applicant: AMGEN INC.

Inventor： Thomas C. BOONE ,  David W. BRANKOW ,  Colin V. GEGG, JR. ,  Shaw-Fen Sylvia HU ,  Chadwick T. KING ,  Hsieng Sen LU ,  Licheng SHI ,  Cen XU

IPC: C07K16/28 ,  A61K39/395

Abstract: Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.

公开(公告)号：US20250129172A1

公开(公告)日：2025-04-24

申请号：US18904787

申请日：2024-10-02

Applicant: AMGEN INC.

Inventor： Thomas C. BOONE ,  David W. BRANKOW ,  Colin V. GEGG, JR. ,  Shaw-Fen Sylvia HU ,  Chadwick T. KING ,  Hsieng Sen LU ,  Licheng SHI ,  Cen XU

IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395 ,  C12N5/10 ,  C12N15/00 ,  C12N15/63 ,  G01N33/53

Abstract: Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.

公开(公告)号：US20210179723A1

公开(公告)日：2021-06-17

申请号：US17111453

申请日：2020-12-03

Applicant: AMGEN INC.

Inventor： Thomas C. BOONE ,  David W. BRANKOW ,  Colin V. GEGG, Jr. ,  Shaw-Fen Sylvia HU ,  Chadwick T. KING ,  Hsieng Sen LU ,  Licheng SHI ,  Cen XU

IPC: C07K16/28 ,  A61K39/395

Abstract: Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.

公开(公告)号：US20180142029A1

公开(公告)日：2018-05-24

申请号：US15824827

申请日：2017-11-28

Applicant: AMGEN INC.

Inventor： Thomas C. BOONE ,  David W. BRANKOW ,  Colin V. GEGG, JR. ,  Shaw-Fen Sylvia HU ,  Chadwick T. KING ,  Hsieng Sen LU ,  Licheng SHI ,  Cen XU

IPC: C07K16/28 ,  A61K39/395 ,  A61K39/00

CPC classification number: C07K16/2869 ,  A61K39/395 ,  A61K39/39533 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/32 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

Abstract: Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.

公开(公告)号：US20140099670A1

公开(公告)日：2014-04-10

申请号：US13843987

申请日：2013-03-15

Applicant: AMGEN INC.

Inventor： Paul KOSTENUIK ,  Wenyan SHEN ,  Thomas C. BOONE

IPC: C07K16/24

CPC classification number: C07K16/241 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2227/105 ,  A01K2267/03 ,  A61K2039/505 ,  C07K14/635 ,  C07K14/70575 ,  C07K16/2875 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2319/00

Abstract: Chimeric molecules comprising receptor activator of NF-κB ligand (RANKL) antibodies and parathyroid hormone/parathyroid hormone-related protein (PTH/PTHrP) peptides are described. Compositions and methods for the treatment of bone diseases are also described.

Abstract translation: 描述了包含NF-κB配体（RANKL）抗体和甲状旁腺激素/甲状旁腺激素相关蛋白（PTH / PTHrP）肽的受体激活剂的嵌合分子。 还描述了用于治疗骨疾病的组合物和方法。