公开(公告)号：US11897963B2

公开(公告)日：2024-02-13

申请号：US17320128

申请日：2021-05-13

Applicant: Amgen Inc.

Inventor： Brian D. Bennett ,  Chadwick T. King ,  Jonathan Phillips

IPC: A61K39/395 ,  C07K16/22 ,  C07K16/28 ,  A61P37/00 ,  C07K14/01 ,  C07K14/475 ,  A61K39/00

CPC classification number: C07K16/2896 ,  A61K39/3955 ,  A61P37/00 ,  C07K16/22 ,  A61K39/39558 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/20

Abstract: Methods of treating conditions related to lung disease using an antigen binding protein specific for the Jagged1 polypeptide are provided.

公开(公告)号：US11059895B2

公开(公告)日：2021-07-13

申请号：US16242278

申请日：2019-01-08

Applicant: Amgen Inc.

Inventor： Dirk E. Smith ,  Ian Foltz ,  Chadwick T. King ,  Ai Ching Lim ,  Rutilio Clark ,  Michael R. Comeau ,  Randal R. Ketchem ,  Donghui Shi ,  Xiaoshan Min ,  Zhulun Wang

IPC: C07K16/28 ,  C07K16/24 ,  A61K39/00 ,  C12N15/11

Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and derivatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.

公开(公告)号：US11028180B2

公开(公告)日：2021-06-08

申请号：US15993448

申请日：2018-05-30

Applicant: AMGEN INC.

Inventor： Brian D. Bennett ,  Chadwick T. King ,  Jonathan Phillips

IPC: A61K39/395 ,  C07K16/22 ,  C07K16/28 ,  A61P37/00 ,  C07K14/52 ,  A61K39/00

Abstract: Methods of treating conditions related to lung disease using an antigen binding protein specific for the Jagged1 polypeptide are provided.