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公开(公告)号:US20180208654A1
公开(公告)日:2018-07-26
申请号:US15878047
申请日:2018-01-23
Applicant: AMGEN INC.
Inventor: Shouhua Xiao , Zheng Pan , Dineli Wickramasinghe , M. Shawn Jeffries , Chadwick Terence King , Brian Mingtung Chan
CPC classification number: C07K16/28 , A61K47/6803 , A61K47/6849 , A61K47/6865 , A61K2039/505 , C07K16/3053 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/77 , C07K2317/92
Abstract: The present disclosure provides a human antibody or antigen binding fragment thereof or an antibody construct comprising a human binding domain or antigen binding fragment thereof capable of binding to human CDH19 on the surface of a target cell. The disclosure relates to a nucleic acid sequence encoding the antibody or antigen binding fragment thereof contained in the antibody construct, a vector comprising the nucleic acid sequence and a host cell transformed or transfected with the vector. Furthermore, the disclosure relates to a process for the production of the antibody construct of the disclosure, a medical use or a method of treatment using the antibody construct and a kit comprising the antibody or antigen binding fragment thereof or the antibody construct.
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公开(公告)号:US20150368343A1
公开(公告)日:2015-12-24
申请号:US14761839
申请日:2014-01-27
Applicant: AMGEN RESEARCH (MUNICH) GMBH , AMGEN INC.
Inventor: Shouhua Xiao , Zheng Pan , Dineli Wickramasinghe , M. Shawn Jeffries , Chadwick Terence King , Brian Mingtung Chan , Peter Kufer , Ralf Lutterbuese , Tobias Raum , Patrick Hoffmann , Doris Rau , Roman Kischel , Bryan Lemon , Holger Wesche
IPC: C07K16/28
CPC classification number: C07K16/2809 , A61K47/60 , A61K2039/505 , C07K16/28 , C07K16/2896 , C07K16/3053 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/77 , C07K2317/92 , C07K2319/00
Abstract: The present invention provides to a antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention relates to a nucleic acid sequence encoding the antibody construct, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention relates a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
Abstract translation: 本发明提供了一种抗体构建物,其包含能够结合靶细胞表面上的人CDH19的第一人结合结构域和能够结合T细胞表面上的人CD3的第二结构域。 此外,本发明涉及编码抗体构建体的核酸序列,包含所述核酸序列的载体和用所述载体转化或转染的宿主细胞。 此外,本发明涉及制备本发明的抗体构建体的方法,所述抗体构建体的医学用途和包含所述抗体构建体的试剂盒。
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