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11.发明授权公开(公告)号：US08309566B2
公开(公告)日：2012-11-13
申请号：US12371550
申请日：2009-02-13
申请人： Somasekhar Bhamidipati , Jeffrey Clough , Ankush Argade , Rajinder Singh , Vadim Markovtosov , Pingyu Ding , Jiaxin Yu , Andy Atuegbu , Hui Hong , Ihab Darwish , Sambaiah Thota
发明人： Somasekhar Bhamidipati , Jeffrey Clough , Ankush Argade , Rajinder Singh , Vadim Markovtosov , Pingyu Ding , Jiaxin Yu , Andy Atuegbu , Hui Hong , Ihab Darwish , Sambaiah Thota
IPC分类号： A61K31/505 , C07D239/02 , C07D401/12
CPC分类号： C07D487/08 , C07D451/00 , C07D451/04 , C07D491/08 , C07D519/00
摘要： This invention is directed to compounds of formula (I): where n, m, Y, R1, R2, R3, R4 and R5 are disclosed herein, as isolated stereoisomers or mixtures thereof, or as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising the compounds of formula (I); and methods of using the compounds and the pharmaceutical compositions in treating diseases or conditions associated with JAK2 activity.
摘要翻译： 本发明涉及式（I）的化合物：其中n，m，Y，R 1，R 2，R 3，R 4和R 5在本文中公开，作为其分离的立体异构体或其混合物，或其药学上可接受的盐; 包含式（I）化合物的药物组合物; 以及使用化合物和药物组合物治疗与JAK2活性相关的疾病或病症的方法。
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12.发明授权公开(公告)号：US08735418B2
公开(公告)日：2014-05-27
申请号：US13619843
申请日：2012-09-14
申请人： Somasekhar Bhamidipati , Jeffrey Clough , Ankush Argade , Rajinder Singh , Vadim Markovtosov , Pingyu Ding , Jiaxin Yu , Andy Atuegbu , Hui Hong , Ihab Darwish , Sambiah Thota
发明人： Somasekhar Bhamidipati , Jeffrey Clough , Ankush Argade , Rajinder Singh , Vadim Markovtosov , Pingyu Ding , Jiaxin Yu , Andy Atuegbu , Hui Hong , Ihab Darwish , Sambiah Thota
IPC分类号： A61K31/505 , A61K31/506
CPC分类号： C07D487/08 , C07D451/00 , C07D451/04 , C07D491/08 , C07D519/00
摘要： This invention is directed to compounds of formula (I): where n, m, Y, R1, R2, R3, R4 and R5 are disclosed herein, as isolated stereoisomers or mixtures thereof, or pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising the compounds of formula (I); and methods of using the compounds and the pharmaceutical compositions in treating diseases or conditions associated with JAK2 activity.
摘要翻译： 本发明涉及式（I）的化合物：其中n，m，Y，R 1，R 2，R 3，R 4和R 5在本文中公开，作为其分离的立体异构体或其混合物或其药学上可接受的盐; 包含式（I）化合物的药物组合物; 以及使用化合物和药物组合物治疗与JAK2活性相关的疾病或病症的方法。
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公开(公告)号：US08809317B2
公开(公告)日：2014-08-19
申请号：US13433378
申请日：2012-03-29
申请人： Clarence R. Hurt , Vishwanath Lingappa , Beverly Freeman , Andy Atuegbu , Anatoliy Kitaygorodskyy
发明人： Clarence R. Hurt , Vishwanath Lingappa , Beverly Freeman , Andy Atuegbu , Anatoliy Kitaygorodskyy
IPC分类号： C07D417/10 , C07D279/20 , A61K31/5415
CPC分类号： C07D279/20
摘要： Compounds and methods for preventing and treating viral infections are provided. In some embodiments, novel compounds broad-spectrum antiviral activity are provided. In more specific embodiments, the compounds and methods are effective against viruses such as Venezuelan Equine Encephalitis, West Nile Virus, and Hepatitis C.
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公开(公告)号：US20120302556A1
公开(公告)日：2012-11-29
申请号：US13433378
申请日：2012-03-29
申请人： Clarence R. Hurt , Vishwanath Lingappa , Beverly Freeman , Andy Atuegbu , Anatoliy Kitaygorodskyy
发明人： Clarence R. Hurt , Vishwanath Lingappa , Beverly Freeman , Andy Atuegbu , Anatoliy Kitaygorodskyy
IPC分类号： A61K31/5415 , C07D417/10 , A61P31/12 , C07D279/20
CPC分类号： C07D279/20
摘要： Compounds and methods for preventing and treating viral infections are provided. In some embodiments, novel compounds broad-spectrum antiviral activity are provided. In more specific embodiments, the compounds and methods are effective against viruses such as Venezuelan Equine Encephalitis, West Nile Virus, and Hepatitis C.
摘要翻译： 提供了用于预防和治疗病毒感染的化合物和方法。 在一些实施方案中，提供新的化合物广谱抗病毒活性。 在更具体的实施方案中，化合物和方法对于诸如委内瑞兰马脑炎，西尼罗病毒和丙型肝炎等病毒是有效的。
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公开(公告)号：US20120270854A1
公开(公告)日：2012-10-25
申请号：US13451608
申请日：2012-04-20
IPC分类号： A61K31/5415 , A61P31/12 , C07D417/04 , C07D417/14 , A61K31/551
CPC分类号： A61K31/5415 , A61K31/551 , C07D279/20 , C07D417/04 , Y02A50/382 , Y02A50/393
摘要： Compounds and methods for preventing and treating viral infections are provided. In some embodiments, novel compounds broad-spectrum antiviral activity are provided. In more specific embodiments, the compounds and methods are effective against viruses such as Venezuelan Equine Encephalitis, West Nile Virus, and Hepatitis C.
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公开(公告)号：US08759336B2
公开(公告)日：2014-06-24
申请号：US13423141
申请日：2012-03-16
申请人： Clarence R. Hurt , Vishwanath Lingappa , Beverly Freeman , Andy Atuegbu , Anatoliy Kitaygorodorskyy
发明人： Clarence R. Hurt , Vishwanath Lingappa , Beverly Freeman , Andy Atuegbu , Anatoliy Kitaygorodorskyy
IPC分类号： C07D279/18 , C07D279/22 , C07D417/10 , A61K31/5415
CPC分类号： C07D417/10 , C07D279/18 , C07D279/22
摘要： Novel compounds, methods, and compositions for treating various viral infections are described. In some embodiments the novel compounds of the invention are 3-oxo-phenothiazine derivatives; more specific embodiments include 3-oxo-phenothiazine derivatives having substituents at the 1-, 7-, and 9-positions of the phenothiazine parent ring. In other embodiments, the invention provides compositions and methods for treating viral infections, especially HIV.
摘要翻译： 描述了用于治疗各种病毒感染的新型化合物，方法和组合物。 在一些实施方案中，本发明的新化合物是3-氧代吩噻嗪衍生物; 更具体的实施方案包括在吩噻嗪母体环的1-，7-和9-位具有取代基的3-氧代 - 吩噻嗪衍生物。 在其它实施方案中，本发明提供用于治疗病毒感染，特别是HIV的组合物和方法。
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公开(公告)号：US08828986B2
公开(公告)日：2014-09-09
申请号：US13451608
申请日：2012-04-20
IPC分类号： C07D417/04 , C07D417/14 , A61K31/5415 , A61K31/551
CPC分类号： A61K31/5415 , A61K31/551 , C07D279/20 , C07D417/04 , Y02A50/382 , Y02A50/393
摘要： Compounds and methods for preventing and treating viral infections are provided. In some embodiments, novel compounds broad-spectrum antiviral activity are provided. In more specific embodiments, the compounds and methods are effective against viruses such as Venezuelan Equine Encephalitis, West Nile Virus, and Hepatitis C.
摘要翻译： 提供了用于预防和治疗病毒感染的化合物和方法。 在一些实施方案中，提供新的化合物广谱抗病毒活性。 在更具体的实施方案中，化合物和方法对于诸如委内瑞兰马脑炎，西尼罗病毒和丙型肝炎等病毒是有效的。
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公开(公告)号：US08785434B2
公开(公告)日：2014-07-22
申请号：US13099006
申请日：2011-05-02
申请人： Clarence R. Hurt , Vishwanath Lingappa , Beverly Freeman , Andy Atuegbu , Anatoliy Kitaygorodskyy
发明人： Clarence R. Hurt , Vishwanath Lingappa , Beverly Freeman , Andy Atuegbu , Anatoliy Kitaygorodskyy
IPC分类号： C07D417/10 , C07D417/14 , A61K31/551 , A61K31/5415
CPC分类号： A61K31/5415 , C07D417/12 , C07D417/14
摘要： Compounds and methods for preventing and treating viral infections are provided. In some embodiments, novel compounds broad-spectrum antiviral activity are provided. In more specific embodiments, the compounds and methods are effective against viruses such as Venezuelan Equine Encephalitis, West Nile Virus, and respiratory viruses including the common cold.
摘要翻译： 提供了用于预防和治疗病毒感染的化合物和方法。 在一些实施方案中，提供新的化合物广谱抗病毒活性。 在更具体的实施方案中，化合物和方法对抗诸如委内瑞兰马脑炎，西尼罗河病毒和包括普通感冒在内的呼吸道病毒的病毒是有效的。
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公开(公告)号：US20120238543A1
公开(公告)日：2012-09-20
申请号：US13423141
申请日：2012-03-16
IPC分类号： A61K31/5415 , C07D279/18 , A61P31/16 , A61P31/12 , A61P31/14 , A61P31/18 , C07D417/10 , C07D279/22
CPC分类号： C07D417/10 , C07D279/18 , C07D279/22
摘要： Novel compounds, methods, and compositions for treating various viral infections are described. In some embodiments the novel compounds of the invention are 3-oxo-phenothiazine derivatives; more specific embodiments include 3-oxo-phenothiazine derivatives having substituents at the 1-, 7-, and 9-positions of the phenothiazine parent ring. In other embodiments, the invention provides compositions and methods for treating viral infections, especially HIV.
摘要翻译： 描述了用于治疗各种病毒感染的新型化合物，方法和组合物。 在一些实施方案中，本发明的新化合物是3-氧代吩噻嗪衍生物; 更具体的实施方案包括在吩噻嗪母体环的1-，7-和9-位具有取代基的3-氧代 - 吩噻嗪衍生物。 在其它实施方案中，本发明提供用于治疗病毒感染，特别是HIV的组合物和方法。
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公开(公告)号：US20120157435A1
公开(公告)日：2012-06-21
申请号：US13099006
申请日：2011-05-02
申请人： Clarence Hurt , Beverly Freeman , Vishwanath Lingappa , Andy Atuegbu , Anatoliy Kitaygorodorskyy
发明人： Clarence Hurt , Beverly Freeman , Vishwanath Lingappa , Andy Atuegbu , Anatoliy Kitaygorodorskyy
IPC分类号： A61K31/551 , A61P31/16 , A61K31/5415 , A61P31/12 , C07D417/10 , C07D417/14
CPC分类号： A61K31/5415 , C07D417/12 , C07D417/14
摘要： Compounds and methods for preventing and treating viral infections are provided. In some embodiments, novel compounds broad-spectrum antiviral activity are provided. In more specific embodiments, the compounds and methods are effective against viruses such as Venezuelan Equine Encephalitis, West Nile Virus, and respiratory viruses including the common cold.
摘要翻译： 提供了用于预防和治疗病毒感染的化合物和方法。 在一些实施方案中，提供新的化合物广谱抗病毒活性。 在更具体的实施方案中，化合物和方法对抗诸如委内瑞兰马脑炎，西尼罗河病毒和包括普通感冒在内的呼吸道病毒的病毒是有效的。
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