公开(公告)号：US06990375B2

公开(公告)日：2006-01-24

申请号：US10087222

申请日：2002-03-01

Applicant: Michael Kloss ,  Angelo Auricchio ,  Veerichetty Kadhiresan

Inventor： Michael Kloss ,  Angelo Auricchio ,  Veerichetty Kadhiresan

IPC: A61N1/365

CPC classification number: A61N1/36514 ,  A61N1/3627

Abstract: A method and system for operating a rate-adaptive pacemaker utilizing minute ventilation to measure exertion level. The method is applicable to heart failure patients who exhibit an oscillatory minute ventilation pattern.

Abstract translation: 一种利用微小通气来测量运动水平的速率自适应起搏器的方法和系统。 该方法适用于表现出振荡分钟通气模式的心力衰竭患者。

公开(公告)号：US06915160B2

公开(公告)日：2005-07-05

申请号：US10071875

申请日：2002-02-08

Applicant: Angelo Auricchio ,  Julio C. Spinelli ,  Andrew P. Kramer

Inventor： Angelo Auricchio ,  Julio C. Spinelli ,  Andrew P. Kramer

IPC: A61B5/0452 ,  A61N1/362 ,  A61N1/368 ,  A61N1/365

CPC classification number: A61N1/3627 ,  A61B5/0452 ,  A61N1/3684

Abstract: A cardiac rhythm management device in which amplitudes of electrograms from one or more cardiac sites are measured in order to ascertain the extent of hypertrophy. The device may then pace the heart by delivering pacing therapy in a manner that unloads the hypertrophied myocardium to effect reversal of undesirable remodeling.

Abstract translation: 一种心律管理装置，其中测量来自一个或多个心脏部位的电描记图，以确定肥大程度。 然后，该装置可以通过以卸载肥厚心肌来实现不期望的重塑逆转的方式通过输送起搏治疗来对心脏进行加速。

公开(公告)号：US06666826B2

公开(公告)日：2003-12-23

申请号：US10038936

申请日：2002-01-04

Applicant: Rodney Salo ,  Angelo Auricchio

Inventor： Rodney Salo ,  Angelo Auricchio

IPC: A61B502

CPC classification number: A61N1/3627 ,  A61N1/056 ,  A61N1/36564 ,  A61N1/368 ,  A61N2001/0585

Abstract: A body implantable system employs a lead system having at least one electrode and at least one pressure transducer at a distal end. The lead system is implanted within a patient's heart in a coronary vein of the left ventricle. The lead system includes an occlusion device at a distal end to occlude flow in the coronary vein. The pressure transducer is attached to a catheter that is disposed within an open lumen of the lead system. The pressure transducer senses a coronary vein pressure, the coronary vein pressure being proportional to the left ventricular pressure. The sensed coronary vein pressure gives indications of hemodynamic state of the left ventricle, and measured coronary vein pressure can be used to change a signal sent to the electrode to adaptively pace the patient's heart. The body implantable system can further utilize a right ventricular pressure measurement in concert with the left ventricular pressure measurement to modify pacing therapy parameters.

Abstract translation: 身体可植入系统采用在远端具有至少一个电极和至少一个压力换能器的引导系统。 引导系统植入患者的心脏左心室冠状静脉。 引导系统包括在远端处的阻塞装置以阻塞冠状静脉中的流动。 压力传感器连接到设置在引导系统的开口腔内的导管。 压力传感器感测冠状静脉压力，冠状静脉压力与左心室压力成比例。 感测到的冠状静脉压力给出了左心室的血液动力学状态的指示，并且可以使用测量的冠状静脉压力来改变发送到电极的信号，以适应性地调节患者的心脏。 身体可植入系统可以进一步利用与左心室压力测量一致的右心室压力测量来修改起搏治疗参数。