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    Heart failure therapy adjustment based on ventricular pressures
    1.
    发明申请
    Heart failure therapy adjustment based on ventricular pressures 有权
    基于心室压力的心力衰竭治疗调整

    公开(公告)号：US20080300643A1

    公开(公告)日：2008-12-04

    申请号：US12221332

    申请日：2008-08-01

    Applicant: Rodney Salo ,  Angelo Auricchio

    Inventor： Rodney Salo ,  Angelo Auricchio

    IPC: A61N1/37

    CPC classification number: A61N1/3627 ,  A61N1/056 ,  A61N1/36564 ,  A61N1/368 ,  A61N2001/0585

    Abstract: Pacing left and right ventricles of the heart for delivery of heart failure therapy involves measuring right ventricular (RV) pressure and a left ventricular (LV) pressure, and computing a parameter developed from one or both of the RV and LV pressure measurements. The parameter is indicative of a degree of left and right ventricular synchronization. At least one parameter of a heart failure pacing therapy is adjusted based on the parameter to improve synchronization of the right and left ventricles.

    Abstract translation: 心脏左心室和右心室起搏用于心力衰竭治疗，用于测量右心室压（RV）压力和左心室压（LV）压力，并计算从RV和LV压力测量中的一个或两个发展的参数。 该参数表示左心室和右心室同步的程度。 基于参数调整心力衰竭起搏治疗的至少一个参数，以改善右心室和左心室的同步。

    Method and apparatus for adjusting interventricular delay based on ventricular pressure
    2.
    发明授权
    Method and apparatus for adjusting interventricular delay based on ventricular pressure 有权
    基于心室压力调节室间延迟的方法和装置

    公开(公告)号：US07409244B2

    公开(公告)日：2008-08-05

    申请号：US10745031

    申请日：2003-12-23

    Applicant: Rodney Salo ,  Angelo Auricchio

    Inventor： Rodney Salo ,  Angelo Auricchio

    IPC: A61N1/365

    CPC classification number: A61N1/3627 ,  A61N1/056 ,  A61N1/36564 ,  A61N1/368 ,  A61N2001/0585

    Abstract: A method and apparatus for pacing left and right ventricles of the heart involve measuring one or both of a right ventricular (RV) pressure and a left ventricular (LV) pressure, and computing a parameter developed from one or both of the RV and LV pressure measurements. The parameter is indicative of a degree of left and right ventricular synchronization. The parameter is assessed, and an interventricular (V-V) delay is adjusted in response to the parameter assessment. The V-V delay is adjusted to effect a change in the parameter that improves synchronization of the right and left ventricles. The computed parameter is a parameter indicative of hemodyamic state, such as a PP Loop or a pre-ejection period.

    Abstract translation: 用于起搏心脏左心室和右心室的方法和装置包括测量右心室（RV）压力和左心室（LV）压力之一或两者，以及计算从RV和LV压力中的一个或两个所产生的参数 测量。 该参数表示左心室和右心室同步的程度。 评估参数，并根据参数评估调整室间（V-V）延迟。 调整V-V延迟以改变参数，改善右心室和左心室的同步。 所计算的参数是指示血液动力学状态的参数，例如PP环或预喷射期。

    Heart failure therapy adjustment based on ventricular pressures
    3.
    发明授权
    Heart failure therapy adjustment based on ventricular pressures 有权
    基于心室压力的心力衰竭治疗调整

    公开(公告)号：US08571657B2

    公开(公告)日：2013-10-29

    申请号：US12221332

    申请日：2008-08-01

    Applicant: Rodney Salo ,  Angelo Auricchio

    Inventor： Rodney Salo ,  Angelo Auricchio

    IPC: A61N1/37

    CPC classification number: A61N1/3627 ,  A61N1/056 ,  A61N1/36564 ,  A61N1/368 ,  A61N2001/0585

    Abstract: Pacing left and right ventricles of the heart for delivery of heart failure therapy involves measuring right ventricular (RV) pressure and a left ventricular (LV) pressure, and computing a parameter developed from one or both of the RV and LV pressure measurements. The parameter is indicative of a degree of left and right ventricular synchronization. At least one parameter of a heart failure pacing therapy is adjusted based on the parameter to improve synchronization of the right and left ventricles.

    Abstract translation: 心脏左心室和右心室起搏用于心力衰竭治疗，用于测量右心室压（RV）压力和左心室压（LV）压力，并计算从RV和LV压力测量中的一个或两个发展的参数。 该参数表示左心室和右心室同步的程度。 基于参数调整心力衰竭起搏治疗的至少一个参数，以改善右心室和左心室的同步。

    Method and apparatus for measuring left ventricular pressure
    4.
    发明授权
    Method and apparatus for measuring left ventricular pressure 失效
    测量左心室压力的方法和装置

    公开(公告)号：US06666826B2

    公开(公告)日：2003-12-23

    申请号：US10038936

    申请日：2002-01-04

    Applicant: Rodney Salo ,  Angelo Auricchio

    Inventor： Rodney Salo ,  Angelo Auricchio

    IPC: A61B502

    CPC classification number: A61N1/3627 ,  A61N1/056 ,  A61N1/36564 ,  A61N1/368 ,  A61N2001/0585

    Abstract: A body implantable system employs a lead system having at least one electrode and at least one pressure transducer at a distal end. The lead system is implanted within a patient's heart in a coronary vein of the left ventricle. The lead system includes an occlusion device at a distal end to occlude flow in the coronary vein. The pressure transducer is attached to a catheter that is disposed within an open lumen of the lead system. The pressure transducer senses a coronary vein pressure, the coronary vein pressure being proportional to the left ventricular pressure. The sensed coronary vein pressure gives indications of hemodynamic state of the left ventricle, and measured coronary vein pressure can be used to change a signal sent to the electrode to adaptively pace the patient's heart. The body implantable system can further utilize a right ventricular pressure measurement in concert with the left ventricular pressure measurement to modify pacing therapy parameters.

    Abstract translation: 身体可植入系统采用在远端具有至少一个电极和至少一个压力换能器的引导系统。 引导系统植入患者的心脏左心室冠状静脉。 引导系统包括在远端处的阻塞装置以阻塞冠状静脉中的流动。 压力传感器连接到设置在引导系统的开口腔内的导管。 压力传感器感测冠状静脉压力，冠状静脉压力与左心室压力成比例。 感测到的冠状静脉压力给出了左心室的血液动力学状态的指示，并且可以使用测量的冠状静脉压力来改变发送到电极的信号，以适应性地调节患者的心脏。 身体可植入系统可以进一步利用与左心室压力测量一致的右心室压力测量来修改起搏治疗参数。

    METHOD AND APPARATUS FOR PREDICTING ACUTE RESPONSE TO CARDIAC RESYNCHRONIZATION THERAPY
    5.
    发明申请
    METHOD AND APPARATUS FOR PREDICTING ACUTE RESPONSE TO CARDIAC RESYNCHRONIZATION THERAPY 有权
    预防心脏康复治疗急性反应的方法和装置

    公开(公告)号：US20080097542A1

    公开(公告)日：2008-04-24

    申请号：US11962708

    申请日：2007-12-21

    Applicant: Yinghong Yu ,  Jiang Ding ,  Julio Spinelli ,  Angelo Auricchio

    Inventor： Yinghong Yu ,  Jiang Ding ,  Julio Spinelli ,  Angelo Auricchio

    IPC: A61N1/365

    CPC classification number: A61N1/3627 ,  A61N1/3682

    Abstract: A method and apparatus for predicting acute response to cardiac resynchronization therapy is disclosed. The method can comprise measuring a first interval during an intrinsic systolic cycle and measuring a second interval during a stimulated systolic cycle. The acute response can be predicted by comparing the percent change in duration between the first interval and the second interval against a pre-determined threshold value. The first and second time intervals can be measured using, for example, a surface ECG or, alternatively, an intracardiac electrogram. In one embodiment, the first interval can be the duration of an intrinsic QRS complex measured during a non-stimulated systolic cycle. Similarly, the second interval can be the duration of a stimulated QRS complex measured during a stimulated systolic cycle.

    Abstract translation: 公开了用于预测心脏再同步治疗的急性反应的方法和装置。 该方法可以包括在本征收缩周期期间测量第一间隔并且在刺激的收缩期期间测量第二间隔。 可以通过将第一间隔和第二间隔之间的持续时间的百分比变化与预定阈值进行比较来预测急性反应。 第一和第二时间间隔可以使用例如表面ECG或者心内电描记图来测量。 在一个实施例中，第一间隔可以是在非刺激的收缩期期间测量的固有QRS复合物的持续时间。 类似地，第二间隔可以是在刺激的收缩期期间测量的受激QRS复合物的持续时间。

    Method and apparatus for predicting acute response to cardiac resynchronization therapy
    6.
    发明授权
    Method and apparatus for predicting acute response to cardiac resynchronization therapy 有权

    公开(公告)号：US06766189B2

    公开(公告)日：2004-07-20

    申请号：US09822790

    申请日：2001-03-30

    Applicant: Yinghong Yu ,  Jiang Ding ,  Julio Spinelli ,  Angelo Auricchio

    Inventor： Yinghong Yu ,  Jiang Ding ,  Julio Spinelli ,  Angelo Auricchio

    IPC: A61B106

    CPC classification number: A61N1/3627 ,  A61N1/3682

    Abstract: A method and apparatus for predicting acute response to cardiac resynchronization therapy is disclosed. The method can comprise measuring a first interval during an intrinsic systolic cycle and measuring a second interval during a stimulated systolic cycle. The acute response can be predicted by comparing the percent change in duration between the first interval and the second interval against a pre-determined threshold value. The first and second time intervals can be measured using, for example, a surface ECG or, alternatively, an intracardiac electrogram. In one embodiment, the first interval can be the duration of an intrinsic QRS complex measured during a non-stimulated systolic cycle. Similarly, the second interval can be the duration of a stimulated QRS complex measured during a stimulated systolic cycle.

    Left ventricular access lead for heart failure pacing
    7.
    发明授权
    Left ventricular access lead for heart failure pacing 失效
    心律失常起搏的左心室通路

    公开(公告)号：US5935160A

    公开(公告)日：1999-08-10

    申请号：US787274

    申请日：1997-01-24

    Applicant: Angelo Auricchio ,  Rodney W. Salo ,  Bruce A. Tockman ,  Ronald W. Heil, Jr. ,  Randy Westlund ,  Stuart R. Chastain

    Inventor： Angelo Auricchio ,  Rodney W. Salo ,  Bruce A. Tockman ,  Ronald W. Heil, Jr. ,  Randy Westlund ,  Stuart R. Chastain

    IPC: A61N1/368 ,  A61N1/05

    CPC classification number: A61N1/056 ,  A61N2001/0585

    Abstract: An elongated monopolar or bipolar coronary vein lead having a reduced outer diameter and especially adapted to be advanced into a selected coronary vein for delivering a pacing signal to a predetermined region of a patient's heart, such as the left ventricle. A method of using the lead for pacing a patient's heart in the treatment of heart failure is also described. The method for pacing the heart includes advancing the coronary vein lead through both the coronary sinus and into a selected coronary vein of a patient's heart, connecting the lead to an electrical pacing source and applying electrical stimulation to a particular chamber of the patient's heart via the implanted lead. The lead includes a flexible tip and transition ring that enhances the ability to guide the lead through the coronary veins.

    Abstract translation: 具有减小的外径的细长单极或双极冠状静脉引线，并且特别适于前进到选定的冠状静脉以将起搏信号传送到患者心脏例如左心室的预定区域。 还描述了使用引线将患者心脏起搏治疗心力衰竭的方法。 用于起搏心脏的方法包括将冠状静脉导管穿过冠状窦并进入患者心脏的选定的冠状静脉，将导线连接到起搏源，并通过电刺激源将电刺激施加到患者心脏的特定腔室 植入铅。 引线包括一个灵活的尖端和过渡环，增强引导引导通过冠状静脉的能力。

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