公开(公告)号：US09988354B2

公开(公告)日：2018-06-05

申请号：US14773436

申请日：2014-03-14

Applicant: AMGEN INC.

Inventor： Sheng Cui ,  Henry Morrison ,  Karthik Nagapudi ,  Shawn Walker ,  Charles Bernard ,  Karl Bennett Hansen ,  Neil Fred Langille ,  Alan Martin Allgeier ,  Steven Mennen ,  Jacqueline Woo

IPC: A61K31/496 ,  A61K47/38 ,  C07D213/75 ,  A61K9/20

CPC classification number: C07D213/75 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K31/496 ,  A61K47/38

Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use. Omecamtiv mecarbil (AMG 423, CK-1827452), having the structure: