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公开(公告)号：US20180312469A1
公开(公告)日：2018-11-01
申请号：US15963529
申请日：2018-04-26
申请人： AMGEN INC. , CYTOKINETICS, INC.
发明人： Sheng Cui , Henry Morrison , Karthik Nagapudi , Shawn Walker , Charles Bernard , Karl Bennett Hansen , Neil Fred Langille , Alan Martin Allgeier , Steven Mennen , Jacqueline Woo , Bradley Paul Morgan , Alex Muci
IPC分类号： C07D213/75 , A61K9/20 , A61K31/496 , A61K47/38
CPC分类号： C07D213/75 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K31/496 , A61K47/38
摘要： Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
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公开(公告)号：US20200331859A1
公开(公告)日：2020-10-22
申请号：US16920155
申请日：2020-07-02
申请人： AMGEN INC. , CYTOKINETICS, INC.
发明人： Sheng Cui , Henry Morrison , Karthik Nagapudi , Shawn Walker , Charles Bernard , Karl Bennett Hansen , Neil Fred Langille , Alan Martin Allgeier , Steven Mennen , Jacqueline C.S. Woo , Bradley Paul Morgan , Alex Muci
IPC分类号： C07D213/75 , A61K9/20 , A61K31/496 , A61K47/38
摘要： Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
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公开(公告)号：US11472773B2
公开(公告)日：2022-10-18
申请号：US16920144
申请日：2020-07-02
申请人： AMGEN INC. , CYTOKINETICS, INC.
发明人： Sheng Cui , Henry Morrison , Karthik Nagapudi , Shawn D. Walker , Charles Bernard , Karl Bennett Hansen , Neil Fred Langille , Alan Martin Allgeier , Steven Mennen , Jacqueline C. S. Woo , Bradley Paul Morgan , Alex Muci
IPC分类号： A61P9/00 , A61P9/04 , C07D213/75 , A61K47/38 , A61K31/496 , A61K9/20
摘要： Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
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公开(公告)号：US20200079736A1
公开(公告)日：2020-03-12
申请号：US16684216
申请日：2019-11-14
申请人： AMGEN INC. , CYTOKINETICS, INC.
发明人： Sheng Cui , Henry Morrison , Karthik Nagapudi , Shawn Walker , Charles Bernard , Karl Bennett Hansen , Neil Fred Langille , Alan Martin Allgeier , Steven Mennen , Jacqueline C.S. Woo , Bradley Paul Morgan , Alex Muci
IPC分类号： C07D213/75 , A61K47/38 , A61K31/496 , A61K9/20
摘要： Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
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公开(公告)号：US20160016906A1
公开(公告)日：2016-01-21
申请号：US14773436
申请日：2014-03-14
申请人： AMGEN INC. , CYTOKINETICS, INC.
发明人： Sheng Cui , Henry Morrison , Karthik Nagapudi , Shawn Walker , Charles Bernard , Karl Bennett Hansen , Neil Fred Langille , Alan Martin Allgeier , Steven Mennen , Jacqueline Woo , Bradley Paul Morgan , Alex Muci
IPC分类号： C07D213/75
CPC分类号： C07D213/75 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K31/496 , A61K47/38
摘要： Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use. Omecamtiv mecarbil (AMG 423, CK-1827452), having the structure:
摘要翻译： 本发明提供了奥美康米卡非二盐酸盐形式，其组合物和药物制剂及其制备和使用方法。 Omecamtiv mecarbil（AMG 423，CK-1827452），具有以下结构：
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公开(公告)号：US09988354B2
公开(公告)日：2018-06-05
申请号：US14773436
申请日：2014-03-14
申请人： AMGEN INC.
发明人： Sheng Cui , Henry Morrison , Karthik Nagapudi , Shawn Walker , Charles Bernard , Karl Bennett Hansen , Neil Fred Langille , Alan Martin Allgeier , Steven Mennen , Jacqueline Woo
IPC分类号： A61K31/496 , A61K47/38 , C07D213/75 , A61K9/20
CPC分类号： C07D213/75 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K31/496 , A61K47/38
摘要： Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use. Omecamtiv mecarbil (AMG 423, CK-1827452), having the structure:
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