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公开(公告)号:US20200079736A1
公开(公告)日:2020-03-12
申请号:US16684216
申请日:2019-11-14
申请人: AMGEN INC. , CYTOKINETICS, INC.
发明人: Sheng Cui , Henry Morrison , Karthik Nagapudi , Shawn Walker , Charles Bernard , Karl Bennett Hansen , Neil Fred Langille , Alan Martin Allgeier , Steven Mennen , Jacqueline C.S. Woo , Bradley Paul Morgan , Alex Muci
IPC分类号: C07D213/75 , A61K47/38 , A61K31/496 , A61K9/20
摘要: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
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公开(公告)号:US20160016906A1
公开(公告)日:2016-01-21
申请号:US14773436
申请日:2014-03-14
申请人: AMGEN INC. , CYTOKINETICS, INC.
发明人: Sheng Cui , Henry Morrison , Karthik Nagapudi , Shawn Walker , Charles Bernard , Karl Bennett Hansen , Neil Fred Langille , Alan Martin Allgeier , Steven Mennen , Jacqueline Woo , Bradley Paul Morgan , Alex Muci
IPC分类号: C07D213/75
CPC分类号: C07D213/75 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K31/496 , A61K47/38
摘要: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use. Omecamtiv mecarbil (AMG 423, CK-1827452), having the structure:
摘要翻译: 本发明提供了奥美康米卡非二盐酸盐形式,其组合物和药物制剂及其制备和使用方法。 Omecamtiv mecarbil(AMG 423,CK-1827452),具有以下结构:
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公开(公告)号:US20180312469A1
公开(公告)日:2018-11-01
申请号:US15963529
申请日:2018-04-26
申请人: AMGEN INC. , CYTOKINETICS, INC.
发明人: Sheng Cui , Henry Morrison , Karthik Nagapudi , Shawn Walker , Charles Bernard , Karl Bennett Hansen , Neil Fred Langille , Alan Martin Allgeier , Steven Mennen , Jacqueline Woo , Bradley Paul Morgan , Alex Muci
IPC分类号: C07D213/75 , A61K9/20 , A61K31/496 , A61K47/38
CPC分类号: C07D213/75 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K31/496 , A61K47/38
摘要: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
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公开(公告)号:US20200331859A1
公开(公告)日:2020-10-22
申请号:US16920155
申请日:2020-07-02
申请人: AMGEN INC. , CYTOKINETICS, INC.
发明人: Sheng Cui , Henry Morrison , Karthik Nagapudi , Shawn Walker , Charles Bernard , Karl Bennett Hansen , Neil Fred Langille , Alan Martin Allgeier , Steven Mennen , Jacqueline C.S. Woo , Bradley Paul Morgan , Alex Muci
IPC分类号: C07D213/75 , A61K9/20 , A61K31/496 , A61K47/38
摘要: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
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公开(公告)号:US09988354B2
公开(公告)日:2018-06-05
申请号:US14773436
申请日:2014-03-14
申请人: AMGEN INC.
发明人: Sheng Cui , Henry Morrison , Karthik Nagapudi , Shawn Walker , Charles Bernard , Karl Bennett Hansen , Neil Fred Langille , Alan Martin Allgeier , Steven Mennen , Jacqueline Woo
IPC分类号: A61K31/496 , A61K47/38 , C07D213/75 , A61K9/20
CPC分类号: C07D213/75 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K31/496 , A61K47/38
摘要: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use. Omecamtiv mecarbil (AMG 423, CK-1827452), having the structure:
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