公开(公告)号：US20090297576A1

公开(公告)日：2009-12-03

申请号：US12131606

申请日：2008-06-02

申请人： Ayala Hezi-Yamit ,  Jennifer Wong

发明人： Ayala Hezi-Yamit ,  Jennifer Wong

IPC分类号： A61K9/00 ,  A61K31/443 ,  A61K31/56 ,  A61K33/00 ,  A61K31/662 ,  A61K39/395 ,  A61K31/7052 ,  A61K31/4353 ,  A61P9/00

CPC分类号： A61K9/1647 ,  A61K9/0024 ,  A61K31/4353 ,  A61K31/443 ,  A61K31/56 ,  A61K31/662 ,  A61K31/7052 ,  A61K45/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/432 ,  A61L2300/45 ,  A61L2300/606 ,  A61K2300/00

摘要： Described herein are methods and medical devices used to deliver bioactive agents locally to patients in need of treatment and/or prevention of cardiovascular conditions Local delivery of protease-activated receptor 1 (PAR-1) antagonists are described herein from implantable medical devices including, but not limited to, stents.

摘要翻译： 本文描述了用于将生物活性剂局部递送给需要治疗和/或预防心血管疾病的患者的方法和医疗装置。本文从可植入医疗装置中描述了蛋白酶活化受体1（PAR-1）拮抗剂的局部递送，包括但不限于 不限于支架。

公开(公告)号：US20050261762A1

公开(公告)日：2005-11-24

申请号：US11123266

申请日：2005-05-05

申请人： Ayala Hezi-Yamit

发明人： Ayala Hezi-Yamit

IPC分类号： A61F2/00 ,  A61F2/02 ,  A61F2/06 ,  A61F2/90

CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2210/0004 ,  A61F2230/0013 ,  A61F2250/0067

摘要： Implantable medical devices having anti-restenotic coatings are disclosed. Specifically, implantable medical devices having coatings of certain anti-inflammatory agents, are disclosed. The-anti-inflammatory agents are selected from the group consisting of ENMD-0997, gusperimus hydrochloride, BMS-561392, CP-461, RDP-58, CNI-1493, CEP-1347, CMT-3, prinomastat, rebimastat, leflunomide, BX-471, DF-1681, BXT-51072, M-40403, LY-293111 sodium, and pharmaceutically acceptable derivatives thereof. The anti-restenotic medical devices include stents, catheters, micro-particles, probes and vascular grafts. Intravascular stents are preferred medical devices. The medical devices can be coated using any method known in the art including compounding the anti-inflammatory agent with a biocompatible polymer prior to applying the coating. Moreover, medical devices composed entirely of biocompatible polymer-anti-inflammatory agent blends are disclosed. Medical devices having a coating comprising at least one anti-inflammatory agent in combination with at least one additional therapeutic agent are also disclosed. Furthermore, related methods of using and making the anti-restenotic implantable devices are disclosed.

摘要翻译： 公开了具有抗再狭窄涂层的植入式医疗装置。 具体地，公开了具有某些抗炎剂的涂层的可植入医疗装置。 抗炎剂选自ENMD-0997，盐酸格斯普利姆，BMS-561392，CP-461，RDP-58，CNI-1493，CEP-1347，CMT-3，优瑞普坦，rebimastat，来氟米特， BX-471，DF-1681，BXT-51072，M-40403，LY-293111钠及其药学上可接受的衍生物。 抗再狭窄医疗器械包括支架，导管，微粒，探针和血管移植物。 血管内支架是优选的医疗装置。 可以使用本领域已知的任何方法涂覆医疗装置，包括在施加涂层之前将抗炎剂与生物相容性聚合物混合。 此外，公开了完全由生物相容性聚合物 - 抗炎剂混合物组成的医疗装置。 还公开了具有包含至少一种抗炎剂与至少一种另外的治疗剂组合的涂层的医疗装置。 此外，公开了使用和制备抗再狭窄植入式装置的相关方法。

公开(公告)号：US20050154452A1

公开(公告)日：2005-07-14

申请号：US10997633

申请日：2004-11-23

申请人： Ayala Hezi-Yamit ,  Sabeena Singh ,  Julie Trudel

发明人： Ayala Hezi-Yamit ,  Sabeena Singh ,  Julie Trudel

IPC分类号： A61F2/00 ,  A61F2/02 ,  A61F2/06 ,  A61F2/90

CPC分类号： A61L31/16 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61L2300/216 ,  A61L2300/416

摘要： Implantable medical devices having anti-restenotic coatings are disclosed. Specifically, implantable medical devices having coatings of certain antiproliferative agents, particularly a certain isoflavonoid, are disclosed. The anti-restenotic isoflavonoid is phenoxodiol, and pharmaceutically acceptable derivatives thereof. The anti-restenotic medical devices include stents, catheters, micro-particles, probes and vascular grafts. Intravascular stents are preferred medical devices. The medical devices can be coated using any method known in the art including compounding the isoflavonoid with a biocompatible polymer prior to applying the coating. Moreover, medical devices composed entirely of biocompatible polymer-isoflavonoid blends are disclosed. Additionally, medical devices having a coating comprising at least one isoflavonoid in combination with at least one additional therapeutic agent are also disclosed. Furthermore, related methods of using and making the anti-restenotic implantable devices are also disclosed.

摘要翻译： 公开了具有抗再狭窄涂层的可植入医疗装置。 具体地，公开了具有某些抗增生剂，特别是某种异黄酮的涂层的可植入医疗装置。 抗再闭塞异黄酮是苯氧二醇及其药学上可接受的衍生物。 抗再狭窄医疗器械包括支架，导管，微粒，探针和血管移植物。 血管内支架是优选的医疗装置。 可以使用本领域已知的任何方法涂覆医疗装置，包括在施加涂层之前将异黄酮与生物相容性聚合物混合。 此外，公开了完全由生物相容性聚合物 - 异黄酮共混物组成的医疗装置。 此外，还公开了具有包含至少一种异黄酮与至少一种另外的治疗剂组合的涂层的医疗装置。 此外，还公开了使用和制备抗再狭窄植入式装置的相关方法。

公开(公告)号：US07713540B2

公开(公告)日：2010-05-11

申请号：US12033497

申请日：2008-02-19

申请人： Joseph D. Berglund ,  Ayala Hezi-Yamit

发明人： Joseph D. Berglund ,  Ayala Hezi-Yamit

IPC分类号： A61F2/00 ,  A61M29/00

CPC分类号： A61M25/1002 ,  A61B17/22 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2017/22081 ,  A61B2017/22084 ,  A61K9/127 ,  A61K47/40 ,  A61L29/16 ,  A61L2300/222 ,  A61L2300/23 ,  A61L2300/252 ,  A61L2300/422 ,  A61M25/1027 ,  A61M2025/1052 ,  A61M2025/1059 ,  A61M2025/1088

摘要： The present disclosure relates to devices methods for the reverse transport of lipids such as cholesterols for the treatment diseases and conditions caused by vulnerable plaques. The devices can reduce or eliminate vulnerable plaques by transporting the plaques away from their location.

摘要翻译： 本公开涉及用于逆转运输脂质如胆固醇的装置方法，用于治疗由易损斑块引起的疾病和病症。 这些装置可以通过将斑块远离其位置来减少或消除易受伤害的斑块。

公开(公告)号：US20050152942A1

公开(公告)日：2005-07-14

申请号：US10996901

申请日：2004-11-23

申请人： Ayala Hezi-Yamit ,  Sabeena Singh ,  Julie Trudel

发明人： Ayala Hezi-Yamit ,  Sabeena Singh ,  Julie Trudel

IPC分类号： A61F2/00 ,  A61F2/02 ,  A61F2/82 ,  A61F2/06

CPC分类号： A61L31/10 ,  A61F2/82 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/434

摘要： Implantable medical devices having anti-restenotic coatings are disclosed. Specifically, implantable medical devices having coatings of certain antiproliferative agents, particularly a certain PKC inhibitor, are disclosed. The anti-restenotic PKC inhibitor is ruboxistaurin, and pharmaceutically acceptable derivatives thereof. The anti-restenotic medical devices include stents, catheters, micro-particles, probes and vascular grafts. Intravascular stents are preferred medical devices. The medical devices can be coated using any method known in the art including compounding the PKC inhibitor with a biocompatible polymer prior to applying the coating. Moreover, medical devices composed entirely of biocompatible polymer-PKC inhibitor blends are disclosed. Additionally, medical devices having a coating comprising at least one PKC inhibitor in combination with at least one additional therapeutic agent are also disclosed. Furthermore, related methods of using and making the anti-restenotic implantable devices are also disclosed.

摘要翻译： 公开了具有抗再狭窄涂层的可植入医疗装置。 具体地，公开了具有某些抗增生剂，特别是某种PKC抑制剂的包衣的可植入医疗装置。 抗再狭窄PKC抑制剂是糠甲醇牛磺酸及其药学上可接受的衍生物。 抗再狭窄医疗器械包括支架，导管，微粒，探针和血管移植物。 血管内支架是优选的医疗装置。 医疗装置可以使用本领域已知的任何方法进行包衣，包括在施加涂层之前将PKC抑制剂与生物相容性聚合物混合。 此外，公开了完全由生物相容性聚合物-PKC抑制剂共混物组成的医疗装置。 此外，还公开了具有包含至少一种PKC抑制剂与至少一种另外的治疗剂组合的包衣的医疗装置。 此外，还公开了使用和制备抗再狭窄植入式装置的相关方法。

公开(公告)号：US20050152940A1

公开(公告)日：2005-07-14

申请号：US10996031

申请日：2004-11-23

申请人： Ayala Hezi-Yamit ,  Sabeena Singh ,  Julie Trudel

发明人： Ayala Hezi-Yamit ,  Sabeena Singh ,  Julie Trudel

IPC分类号： A61F2/00 ,  A61F2/02 ,  A61F2/06 ,  A61F2/90

CPC分类号： A61L31/16 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/432

摘要： Implantable medical devices having anti-restenotic coatings are disclosed. Specifically, implantable medical devices having coatings of certain antiproliferative agents, particularly a certain KSP inhibitor, are disclosed. The anti-restenotic KSP inhibitor is CK-0238273, and pharmaceutically acceptable derivatives thereof. The anti-restenotic medical devices include stents, catheters, micro-particles, probes and vascular grafts. Intravascular stents are preferred medical devices. The medical devices can be coated using any method known in the art including compounding the KSP inhibitor with a biocompatible polymer prior to applying the coating. Moreover, medical devices composed entirely of biocompatible polymer-KSP inhibitor blends are disclosed. Additionally, medical devices having a coating comprising at least one KSP inhibitor in combination with at least one additional therapeutic agent are also disclosed. Furthermore, related methods of using and making the anti-restenotic implantable devices are also disclosed.

摘要翻译： 公开了具有抗再狭窄涂层的可植入医疗装置。 具体地，公开了具有某些抗增生剂，特别是某种KSP抑制剂的包衣的可植入医疗装置。 抗再狭窄KSP抑制剂是CK-0238273及其药学上可接受的衍生物。 抗再狭窄医疗器械包括支架，导管，微粒，探针和血管移植物。 血管内支架是优选的医疗装置。 可以使用本领域已知的任何方法涂覆医疗装置，包括在施加涂层之前将KSP抑制剂与生物相容性聚合物混合。 此外，公开了完全由生物相容性聚合物-KSP抑制剂共混物组成的医疗装置。 此外，还公开了具有包含至少一种KSP抑制剂与至少一种另外的治疗剂组合的涂层的医疗装置。 此外，还公开了使用和制备抗再狭窄植入式装置的相关方法。

公开(公告)号：US20050228490A1

公开(公告)日：2005-10-13

申请号：US11085739

申请日：2005-03-21

申请人： Ayala Hezi-Yamit ,  Sabeena Singh ,  Julie Trudel

发明人： Ayala Hezi-Yamit ,  Sabeena Singh ,  Julie Trudel

IPC分类号： A61F2/00 ,  A61F2/90 ,  A61F2/06

CPC分类号： A61F2/90 ,  A61F2250/0067

摘要： Implantable medical devices having anti-restenotic coatings are disclosed. Specifically, implantable medical devices having coatings of certain antiproliferative agents, particularly a certain antiproliferative agent, are disclosed. The anti-restenotic antiproliferative agent is BMS-181176, and pharmaceutically acceptable derivatives thereof. The anti-restenotic medical devices include stents, catheters, micro-particles, probes and vascular grafts. Intravascular stents are preferred medical devices. The medical devices can be coated using any method known in the art including compounding the antiproliferative agent with a biocompatible polymer prior to applying the coating. Moreover, medical devices composed entirely of biocompatible polymer-antiproliferative agent blends are disclosed. Additionally, medical devices having a coating comprising at least one antiproliferative agent in combination with at least one additional therapeutic agent are also disclosed. Furthermore, related methods of using and making the anti-restenotic implantable devices are also disclosed.

摘要翻译： 公开了具有抗再狭窄涂层的植入式医疗装置。 具体地，公开了具有某些抗增生剂，特别是某种抗增殖剂的包衣的可植入医疗装置。 抗再闭塞抗增生剂是BMS-181176及其药学上可接受的衍生物。 抗再狭窄医疗器械包括支架，导管，微粒，探针和血管移植物。 血管内支架是优选的医疗装置。 可以使用本领域已知的任何方法涂覆医疗装置，包括在施加涂层之前将抗增殖剂与生物相容性聚合物混合。 此外，公开了完全由生物相容性聚合物 - 抗增殖剂混合物组成的医疗装置。 此外，还公开了具有包含至少一种抗增殖剂与至少一种另外的治疗剂组合的包衣的医疗装置。 此外，还公开了使用和制备抗再狭窄植入式装置的相关方法。

公开(公告)号：US20050197691A1

公开(公告)日：2005-09-08

申请号：US11053744

申请日：2005-02-08

申请人： Ayala Hezi-Yamit ,  Sabeena Singh ,  Julie Trudel

发明人： Ayala Hezi-Yamit ,  Sabeena Singh ,  Julie Trudel

IPC分类号： A61F2/06

CPC分类号： A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/436 ,  A61L2300/606

摘要： Implantable medical devices having anti-restenotic coatings are disclosed. Specifically, implantable medical devices having coatings of certain antiproliferative agents, particularly a certain PDGF receptor inhibitor, are disclosed. The anti-restenotic PDGF receptor inhibitor is MLN-518, and pharmaceutically acceptable derivatives thereof. The anti-restenotic medical devices include stents, catheters, micro-particles, probes and vascular grafts. Intravascular stents are preferred medical devices. The medical devices can be coated using any method known in the art including compounding the PDGF receptor inhibitor with a biocompatible polymer prior to applying the coating. Moreover, medical devices composed entirely of biocompatible polymer-PDGF receptor inhibitor blends are disclosed. Additionally, medical devices having a coating comprising at least one PDGF receptor inhibitor in combination with at least one additional therapeutic agent are also disclosed. Furthermore, related methods of using and making the anti-restenotic implantable devices are also disclosed.

摘要翻译： 公开了具有抗再狭窄涂层的可植入医疗装置。 具体地，公开了具有某些抗增生剂，特别是某些PDGF受体抑制剂的包衣的可植入医疗器械。 抗再狭窄PDGF受体抑制剂是MLN-518及其药学上可接受的衍生物。 抗再狭窄医疗器械包括支架，导管，微粒，探针和血管移植物。 血管内支架是优选的医疗装置。 可以使用本领域已知的任何方法涂覆医疗装置，包括在施加涂层之前将PDGF受体抑制剂与生物相容性聚合物混合。 此外，公开了完全由生物相容性聚合物-PDGF受体抑制剂共混物组成的医疗装置。 此外，还公开了具有包含至少一种PDGF受体抑制剂与至少一种另外的治疗剂组合的包衣的医疗装置。 此外，还公开了使用和制备抗再狭窄植入式装置的相关方法。

公开(公告)号：US20050152943A1

公开(公告)日：2005-07-14

申请号：US10997289

申请日：2004-11-23

申请人： Ayala Hezi-Yamit ,  Sabeena Singh ,  Julie Trudel

发明人： Ayala Hezi-Yamit ,  Sabeena Singh ,  Julie Trudel

IPC分类号： A61F2/00 ,  A61F2/90 ,  A61L31/10 ,  A61L31/16

CPC分类号： A61L31/10 ,  A61F2/90 ,  A61F2250/0067 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/436

摘要： Implantable medical devices having anti-restenotic coatings are disclosed. Specifically, implantable medical devices having coatings of certain antiproliferative agents, particularly a certain PDGF receptor inhibitor, are disclosed. The anti-restenotic PDGF receptor inhibitor is SU-11248, and pharmaceutically acceptable derivatives thereof. The anti-restenotic medical devices include stents, catheters, micro-particles, probes and vascular grafts. Intravascular stents are preferred medical devices. The medical devices can be coated using any method known in the art including compounding the PDGF receptor inhibitor with a biocompatible polymer prior to applying the coating. Moreover, medical devices composed entirely of biocompatible polymer-PDGF receptor inhibitor blends are disclosed. Additionally, medical devices having a coating comprising at least one PDGF receptor inhibitor in combination with at least one additional therapeutic agent are also disclosed. Furthermore, related methods of using and making the anti-restenotic implantable devices are also disclosed.

摘要翻译： 公开了具有抗再狭窄涂层的可植入医疗装置。 具体地，公开了具有某些抗增生剂，特别是某些PDGF受体抑制剂的包衣的可植入医疗器械。 抗再狭窄PDGF受体抑制剂是SU-11248及其药学上可接受的衍生物。 抗再狭窄医疗器械包括支架，导管，微粒，探针和血管移植物。 血管内支架是优选的医疗装置。 可以使用本领域已知的任何方法涂覆医疗装置，包括在施加涂层之前将PDGF受体抑制剂与生物相容性聚合物混合。 此外，公开了完全由生物相容性聚合物-PDGF受体抑制剂共混物组成的医疗装置。 此外，还公开了具有包含至少一种PDGF受体抑制剂与至少一种另外的治疗剂组合的包衣的医疗装置。 此外，还公开了使用和制备抗再狭窄植入式装置的相关方法。

公开(公告)号：US20050137683A1

公开(公告)日：2005-06-23

申请号：US10997662

申请日：2004-11-23

申请人： Ayala Hezi-Yamit ,  Sabeena Singh ,  Julie Trudel

发明人： Ayala Hezi-Yamit ,  Sabeena Singh ,  Julie Trudel

IPC分类号： A61F2/00 ,  A61F2/90 ,  A61F2/06

CPC分类号： A61F2/90 ,  A61F2210/0076 ,  A61F2250/0067

摘要： Implantable medical devices having anti-restenotic coatings are disclosed. Specifically, implantable medical devices having coatings of certain antiproliferative agents, particularly a certain endothelin receptor inhibitor, are disclosed. The anti-restenotic endothelin receptor inhibitor is atrasentan, and pharmaceutically acceptable derivatives thereof. The anti-restenotic medical devices include stents, catheters, micro-particles, probes and vascular grafts. Intravascular stents are preferred medical devices. The medical devices can be coated using any method known in the art including compounding the endothelin receptor inhibitor with a biocompatible polymer prior to applying the coating. Moreover, medical devices composed entirely of biocompatible polymer-endothelin receptor inhibitor blends are disclosed. Additionally, medical devices having a coating comprising at least one endothelin receptor inhibitor in combination with at least one additional therapeutic agent are also disclosed. Furthermore, related methods of using and making the anti-restenotic implantable devices are also disclosed.

摘要翻译： 公开了具有抗再狭窄涂层的可植入医疗装置。 具体地，公开了具有某些抗增生剂，特别是某些内皮素受体抑制剂的包衣的可植入医疗器械。 抗再狭窄内皮素受体抑制剂是阿替司坦及其药学上可接受的衍生物。 抗再狭窄医疗器械包括支架，导管，微粒，探针和血管移植物。 血管内支架是优选的医疗装置。 可以使用本领域已知的任何方法涂覆医疗装置，包括在施加涂层之前将内皮素受体抑制剂与生物相容性聚合物混合。 此外，公开了完全由生物相容性聚合物 - 内皮素受体抑制剂共混物组成的医疗装置。 此外，还公开了具有包含至少一种内皮素受体抑制剂与至少一种另外的治疗剂组合的包衣的医疗装置。 此外，还公开了使用和制备抗再狭窄植入式装置的相关方法。