公开(公告)号：US20190167819A1

公开(公告)日：2019-06-06

申请号：US16092905

申请日：2017-04-05

Applicant: BRACCO IMAGING S.P.A.

Inventor： Luciano LATTUADA ,  Roberta NAPOLITANO ,  Valeria BOI ,  Massimo VISIGALLI ,  Silvio AIME ,  Giovanni Battista GIOVENZANA ,  Alberto FRINGUELLO MINGO

IPC: A61K49/10 ,  C07F9/6524 ,  A61B5/055 ,  G01R33/56

Abstract: The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.

公开(公告)号：US20180362511A1

公开(公告)日：2018-12-20

申请号：US16060754

申请日：2016-12-12

Applicant: BRACCO IMAGING S.P.A.

Inventor： Valeria BOI ,  Roberta NAPOLITANO ,  Luciano LATTUADA

IPC: C07D403/12

CPC classification number: C07D403/12 ,  A61K49/108 ,  A61K49/122 ,  C07D257/02

Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.