公开(公告)号：US20190167819A1

公开(公告)日：2019-06-06

申请号：US16092905

申请日：2017-04-05

Applicant: BRACCO IMAGING S.P.A.

Inventor： Luciano LATTUADA ,  Roberta NAPOLITANO ,  Valeria BOI ,  Massimo VISIGALLI ,  Silvio AIME ,  Giovanni Battista GIOVENZANA ,  Alberto FRINGUELLO MINGO

IPC: A61K49/10 ,  C07F9/6524 ,  A61B5/055 ,  G01R33/56

Abstract: The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.

公开(公告)号：US20200325108A1

公开(公告)日：2020-10-15

申请号：US16916817

申请日：2020-06-30

Applicant: BRACCO IMAGING S.P.A.

Inventor： Luciano LATTUADA ,  Roberta NAPOLITANO ,  Valeria BOI ,  Massimo VISIGALLI ,  Silvio AIME ,  Giovanni Battista GIOVENZANA ,  Alberto FRINGUELLO MINGO

IPC: C07D257/02 ,  A61K49/10 ,  C07D401/06

Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.

公开(公告)号：US20240131199A1

公开(公告)日：2024-04-25

申请号：US18267590

申请日：2021-12-16

Applicant: BRACCO IMAGING S.P.A. ,  SURGVISION GMBH

Inventor： Roberta NAPOLITANO ,  Francesco BLASI ,  Fulvio FERRETTI ,  Nicolò DIALE ,  Federica BUONSANTI ,  Massimo VISIGALLI ,  Alessia ADAMO

IPC: A61K49/00 ,  C09B23/01 ,  G01N21/64 ,  G01N33/58

CPC classification number: A61K49/0032 ,  C09B23/0066 ,  G01N21/6486 ,  G01N33/582

Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to a class of monoalkylated cyanine dyes with red to near-infrared (650-900 nm) emission characterized by pH responsiveness and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them. The monoalkylated cyanine dyes have general formula (I) wherein R1 and R3 are independently selected from the group consisting of hydrogen, -SO3H, —COOH and —CONH—Y; and R2 and R4 are hydrogen, or both R1 together with R2 and R3 together with R4, respectively and with the atoms to which they are bonded, form two aryl rings, optionally substituted with from 1 to 4 -SO3H groups; R5 is an alkyl optionally substituted by a group selected from —SO3H, —COOH and —CONH2.

公开(公告)号：US20180362476A1

公开(公告)日：2018-12-20

申请号：US16060577

申请日：2016-12-12

Applicant: BRACCO IMAGING S.P.A.

Inventor： Luciano LATTUADA ,  Roberta NAPOLITANO ,  Valeria BOI ,  Massimo VISIGALLI ,  Silvio AIME ,  Giovanni Battista GIOVENZANA ,  Alberto FRINGUELLO MINGO

IPC: C07D257/02 ,  C07D401/06 ,  A61K49/10

Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.5