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公开(公告)号：US20230303592A1
公开(公告)日：2023-09-28
申请号：US18017939
申请日：2021-07-26
发明人： Andrea BARALE , Valeria BOI , Aurelia FERRIGATO , Sonia GAZZETTO , Daniela GIARDINA-PAPA , Armando MORTILLARO , Laura ORIO , Massimo VERANI
IPC分类号： C07F5/00
CPC分类号： C07F5/003
摘要： The invention relates to a process for the preparation of dimeric contrast agents for use in Magnetic resonance Imaging (MRI), in particular [μ-[1-[bis[2-(hydroxy-kO)-3-[4,7,10-tris[(carboxy-kO)methyl]-1,4,7,10-tetraazacyclododec-1-yl-kN1,kN4,kN7,kN10]propyl]amino]-1-deoxy-D-glucitolato(6-)]]di-gadolinium complex, which includes preparation steps carried out one-pot and without isolation of the obtained intermediate.
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公开(公告)号：US20230040008A1
公开(公告)日：2023-02-09
申请号：US17786768
申请日：2020-12-16
发明人： Erika REITANO , Alessandro MAIOCCHI , Luisa POGGI , Federico CRIVELLIN , Simon HUET , Mathieu CINIER , Olivier KITTEN
摘要： The present invention provides new polypeptide derivatives binding to Human Epidermal Growth Factor Receptor 2 (HER2) and their conjugates thereof, and to their use as a diagnostic agent, particularly for early detection, patient stratification and treatment monitoring of forms of cancer characterized by over-expression of HER2.
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公开(公告)号：US20220348923A1
公开(公告)日：2022-11-03
申请号：US17642753
申请日：2020-09-16
发明人： Vittorio DE FRANCISCIS , Carla Lucia ESPOSITO , Silvia CATUOGNO , Silvia NUZZO , Alessandro MAIOCCHI , Margherita IABONI , Aldo DI VITO , Erika REITANO , Luisa POGGI
IPC分类号： C12N15/115 , C12Q1/6886 , A61K45/06
摘要： The present invention provides nucleic acid aptamers binding to the Carbonic Anhydrase IX (CA-IX) enzyme, derivatives and conjugates thereof and their use as diagnostic tools, particularly for the imaging of organs and tissues expressing CA-IX, or as therapeutic agents for prevention or treatment of CA-IX related diseases.
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公开(公告)号：US20210196840A1
公开(公告)日：2021-07-01
申请号：US17199122
申请日：2021-03-11
摘要： The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutamic glutaric acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.
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公开(公告)号：US11021451B2
公开(公告)日：2021-06-01
申请号：US16916817
申请日：2020-06-30
发明人： Luciano Lattuada , Roberta Napolitano , Valeria Boi , Massimo Visigalli , Silvio Aime , Giovanni Battista Giovenzana , Alberto Fringuello Mingo
IPC分类号： C07D257/02 , A61K49/10 , C07D401/06
摘要： The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
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公开(公告)号：US11007283B2
公开(公告)日：2021-05-18
申请号：US16092905
申请日：2017-04-05
发明人： Luciano Lattuada , Roberta Napolitano , Valeria Boi , Massimo Visigalli , Silvio Aime , Giovanni Battista Giovenzana , Alberto Fringuello Mingo
IPC分类号： A61K49/10 , A61B5/055 , C07F9/6524 , C07D257/02 , G01R33/56
摘要： The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
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公开(公告)号：US20200317722A1
公开(公告)日：2020-10-08
申请号：US16769633
申请日：2018-12-05
摘要： The present invention discloses a solid-phase process for the preparation of a Near Infra-Red (NIR) fluorescent probe characterized by an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety and used in the guided surgery of tumors and pathologic regions.
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公开(公告)号：US10738000B2
公开(公告)日：2020-08-11
申请号：US16276252
申请日：2019-02-14
发明人： Roberta Fretta , Pietro Delogu , Fernanda Di Giorgio , Alfonso Nardelli , Stefano Sguassero , Carlo Felice Viscardi
IPC分类号： C07C67/08 , C07C67/287 , C07C51/44 , B01D3/00 , C07C67/54
摘要： The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid.The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.
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公开(公告)号：US20200017453A1
公开(公告)日：2020-01-16
申请号：US16468035
申请日：2017-12-11
IPC分类号： C07D257/02 , A61K49/10
摘要： The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with the paramagnetic metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
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公开(公告)号：US10519171B2
公开(公告)日：2019-12-31
申请号：US15321176
申请日：2015-07-20
摘要： The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of the said compound in a suitable solvent A wherein the amount by weight of the water optionally present in the solution is at most equal to or lower than the amount by weight of the gadobenate dimeglumine comprised in the solution and adding the obtained solution to an organic solvent B, acting as an appropriate antisolvent and favoring the formation of a solid form of the gadobenate dimeglumine that can be collected by filtration.
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