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    OXIME ETHER COMPOUNDS
    18.
    发明申请
    OXIME ETHER COMPOUNDS 有权

    公开(公告)号：US20210147361A1

    公开(公告)日：2021-05-20

    申请号：US16636662

    申请日：2018-08-08

    Applicant: BRISTOL-MYERS SQUIBB COMPANY

    Inventor： Alaric J. Dyckman ,  Ling Li ,  T.G. Murali Dhar ,  Hai-Yun Xiao

    IPC: C07D213/53 ,  C07D207/12 ,  C07D211/40 ,  C07D211/96 ,  A61P37/06

    Abstract: Disclosed are compounds of Formula (I): (I) or a salt thereof, wherein: X is CH or N; Y is CH or N; R1 is —OH or —OP(O)(OH)2; L1 is —CR3═N—O—CRaRa— or CRaR—O—N═CR3; L2 is a bond, —C(O)—, or S(O)2—; and R2, R3, Ra, m, and n are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

    ALKYLPHENYL COMPOUNDS
    19.
    发明申请
    ALKYLPHENYL COMPOUNDS 有权

    公开(公告)号：US20210147357A1

    公开(公告)日：2021-05-20

    申请号：US16636670

    申请日：2018-08-08

    Applicant: BRISTOL-MYERS SQUIBB COMPANY

    Inventor： Alaric J. Dyckman ,  Ling Li ,  John L. Gilmore

    IPC: C07D207/16

    Abstract: Disclosed are compounds of Formula (I): (I) or a salt thereof, wherein: X is —CH2— or —C(O)—; R1 is —OH or —OP(O)(OH)2; L is a bond, —CH2—, or —C(O)—; R2 is n-C6-8 alkyl; each R3 is independently selected from Cl and —CH3; and n is zero, 1, or 2; provided that if X is —CH2—, then L is —CH2— or —C(O)—. Also disclosed are methods of using such compounds as selective agonists for G protein coupled receptor SlP1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

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