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公开(公告)号：US20240124489A1
公开(公告)日：2024-04-18
申请号：US17766198
申请日：2020-09-30
发明人： Sreekantha Ratna Kumar , Lazman Pasunoori , Subramanya Hegde , Anupama Kandhi , Durga Buchi Paju Barre , Alaric J. Dyckman
IPC分类号： C07D513/04 , C07D519/00
CPC分类号： C07D513/04 , C07D519/00
摘要： Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein X, Y, A, G, R1, and R5 are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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公开(公告)号：US11878975B2
公开(公告)日：2024-01-23
申请号：US16955097
申请日：2018-12-18
发明人： Alaric J. Dyckman , Dharmpal S. Dodd , Christopher P. Mussari , John L. Gilmore , Tasir Shamsul Haque , Trevor C. Sherwood , Brian K. Whiteley , Shoshana L. Posy , Sreekantha Ratna Kumar , Laxman Pasunoori , Srinivasan Kunchithapatham Duraisamy , Subramanya Hegde , Rushith Kumar Anumula , Pitani Veera Venkata Srinivas
IPC分类号： C07D471/08 , C07D487/08 , C07D519/00 , C07D471/04 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/02 , C07D487/04 , C07D491/08
CPC分类号： C07D471/04 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/02 , C07D487/04 , C07D491/08
摘要： Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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公开(公告)号：US11701373B2
公开(公告)日：2023-07-18
申请号：US17307138
申请日：2021-05-04
发明人： Alaric J. Dyckman , T. G. Murali Dhar , Hai-Yun Xiao , John L. Gilmore , Michael G. Yang , Zili Xiao , David Marcoux
IPC分类号： A61K31/695 , C07F7/08 , A61K31/135 , C07D215/14 , C07D241/04 , C07C323/29 , C07C251/38 , C07C251/42 , C07C251/44 , C07D209/46 , C07D213/38 , C07C275/26 , C07C217/74 , C07C323/25 , C07C235/46 , C07F9/54 , C07F9/572 , C07F9/09 , C07C215/42 , C07C217/52 , C07C217/58 , C07C219/24 , C07C233/41 , C07C233/65 , C07C251/50 , C07C251/52 , C07C251/54 , C07C271/34 , C07C317/28 , C07C317/32 , C07C321/16 , C07C321/22 , C07C321/28 , C07D213/32 , C07D213/69 , C07D213/70 , C07D215/12 , C07D217/24 , C07D231/12 , C07D231/20 , C07D239/26 , C07D241/12 , C07D277/24 , C07D305/08 , C07D309/06 , C07D309/12 , C07D311/58 , C07D311/76 , C07D319/20 , C07D333/16 , C07F9/117 , C07F9/62 , C07F9/6503 , C07F9/6509 , C07F9/655 , C07F9/6553 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/222 , A61K31/24 , A61K31/27 , A61K31/337 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/415 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4965 , A61K31/505 , A61K31/661
CPC分类号： A61K31/695 , A61K31/135 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/222 , A61K31/24 , A61K31/27 , A61K31/337 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/415 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4965 , A61K31/505 , A61K31/661 , C07C215/42 , C07C217/52 , C07C217/58 , C07C217/74 , C07C219/24 , C07C233/41 , C07C233/65 , C07C235/46 , C07C251/38 , C07C251/42 , C07C251/44 , C07C251/50 , C07C251/52 , C07C251/54 , C07C271/34 , C07C275/26 , C07C317/28 , C07C317/32 , C07C321/16 , C07C321/22 , C07C321/28 , C07C323/25 , C07C323/29 , C07D209/46 , C07D213/32 , C07D213/38 , C07D213/69 , C07D213/70 , C07D215/12 , C07D215/14 , C07D217/24 , C07D231/12 , C07D231/20 , C07D239/26 , C07D241/04 , C07D241/12 , C07D277/24 , C07D305/08 , C07D309/06 , C07D309/12 , C07D311/58 , C07D311/76 , C07D319/20 , C07D333/16 , C07F7/08 , C07F7/081 , C07F9/091 , C07F9/117 , C07F9/5442 , C07F9/5728 , C07F9/62 , C07F9/65031 , C07F9/65522 , C07F9/650952 , C07F9/655345 , C07B2200/05 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2602/10 , C07C2603/74
摘要： Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V):
and/or a salt thereof, wherein R1 is —OH or —OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.-
公开(公告)号：US20230020273A1
公开(公告)日：2023-01-19
申请号：US17289269
申请日：2019-10-28
发明人： Steven H. Spergel , William J. Pitts , Michael E. Mertzman , Ryan M. Moslin , Trevor C. Sherwood , John L. Gilmore , Alaric J. Dyckman
IPC分类号： C07D413/14 , C07B59/00 , C07D403/12 , C07D413/12 , C07D417/14 , C07D417/12 , C07D401/14 , C07D403/14
摘要： Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.
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公开(公告)号：US11427580B2
公开(公告)日：2022-08-30
申请号：US16955089
申请日：2018-12-18
发明人： Alaric J. Dyckman , Dharmpal S. Dodd , Sreekantha Ratna Kumar , Durga Buchi Raju Barre , Srinivasan Kunchithapatham Duraisamy
IPC分类号： C07D471/04 , C07D519/00
摘要： Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein A, G, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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公开(公告)号：US20200308195A1
公开(公告)日：2020-10-01
申请号：US16955108
申请日：2018-12-18
发明人： Alaric J. Dyckman , Dharmpal S. Dodd , Christopher P. Mussari , Brian K. Whiteley , Sreekantha Ratna Kumar , Anupama Kandhi Ramachandra Reddy
IPC分类号： C07D519/00 , C07D487/04
摘要： Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, X, Y, Z, R1, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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公开(公告)号：US10709719B2
公开(公告)日：2020-07-14
申请号：US16188444
申请日：2018-11-13
发明人： Alaric J. Dyckman , T. G. Murali Dhar , Hai-Yun Xiao , John L. Gilmore , Michael G. Yang , Zili Xiao , David Marcoux
IPC分类号： A61K31/695 , C07F7/08 , A61K31/135 , C07D215/14 , C07D241/04 , C07C323/29 , C07C251/38 , C07C251/42 , C07C251/44 , C07D209/46 , C07D213/38 , C07C275/26 , C07C217/74 , C07C323/25 , C07C235/46 , C07F9/54 , C07F9/572 , C07F9/09 , C07C215/42 , C07C217/52 , C07C217/58 , C07C219/24 , C07C233/41 , C07C233/65 , C07C251/50 , C07C251/52 , C07C251/54 , C07C271/34 , C07C317/28 , C07C317/32 , C07C321/16 , C07C321/22 , C07C321/28 , C07D213/32 , C07D213/69 , C07D213/70 , C07D215/12 , C07D217/24 , C07D231/12 , C07D231/20 , C07D239/26 , C07D241/12 , C07D277/24 , C07D305/08 , C07D309/06 , C07D309/12 , C07D311/58 , C07D311/76 , C07D319/20 , C07D333/16 , C07F9/117 , C07F9/62 , C07F9/6503 , C07F9/6509 , C07F9/655 , C07F9/6553 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/222 , A61K31/24 , A61K31/27 , A61K31/337 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/415 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4965 , A61K31/505 , A61K31/661
摘要： Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): and/or a salt thereof, wherein R1 is —OH or —OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
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公开(公告)号：US20170042917A1
公开(公告)日：2017-02-16
申请号：US15337843
申请日：2016-10-28
发明人： Alaric J. Dyckman , T.G. Murali Dhar , Hai-Yun Xiao , John L. Gilmore , Michael G. Yang , Zili Xiao , David Marcoux
IPC分类号： A61K31/695 , A61K31/351 , A61K31/415 , A61K31/381 , A61K31/44 , A61K31/137 , A61K31/166 , A61K31/4406 , A61K31/4409 , A61K31/4402 , A61K31/4965 , A61K31/165 , A61K31/4174 , A61K31/426 , A61K31/337 , A61K31/47 , A61K31/505 , A61K31/27 , A61K31/17 , A61K31/352 , A61K31/15 , A61K31/661 , A61K31/222 , A61K31/24 , A61K31/135
CPC分类号： A61K31/695 , A61K31/135 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/222 , A61K31/24 , A61K31/27 , A61K31/337 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/415 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4965 , A61K31/505 , A61K31/661 , C07B2200/05 , C07C215/42 , C07C217/52 , C07C217/58 , C07C217/74 , C07C219/24 , C07C233/41 , C07C233/65 , C07C235/46 , C07C251/38 , C07C251/42 , C07C251/44 , C07C251/50 , C07C251/52 , C07C251/54 , C07C271/34 , C07C275/26 , C07C317/28 , C07C317/32 , C07C321/16 , C07C321/22 , C07C321/28 , C07C323/25 , C07C323/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2602/10 , C07C2603/74 , C07D209/46 , C07D213/32 , C07D213/38 , C07D213/69 , C07D213/70 , C07D215/12 , C07D215/14 , C07D217/24 , C07D231/12 , C07D231/20 , C07D239/26 , C07D241/04 , C07D241/12 , C07D277/24 , C07D305/08 , C07D309/06 , C07D309/12 , C07D311/58 , C07D311/76 , C07D319/20 , C07D333/16 , C07F7/081 , C07F9/091 , C07F9/117 , C07F9/5442 , C07F9/5728 , C07F9/62 , C07F9/65031 , C07F9/650952 , C07F9/65522 , C07F9/655345
摘要： Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): and/or a salt thereof, wherein R1 is —OH or —OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
摘要翻译： 和/或其盐，其中R1是-OH或-OP（O）（OH）2，X1，X2，X3，R2，R2a，Ra，Rb和Rc在本文中定义。 还公开了使用这种化合物作为G蛋白偶联受体S1P1的选择性激动剂的方法，以及包含这些化合物的药物组合物。 这些化合物可用于治疗，预防或减缓各种治疗领域（例如自身免疫疾病和血管疾病）中的疾病或病症的进展。
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公开(公告)号：US20140235591A1
公开(公告)日：2014-08-21
申请号：US14185164
申请日：2014-02-20
发明人： T. G. Murali Dhar , Hai-Yun Xiao , Alaric J. Dyckman , Eric J. Chan , Marta Dabros , Daniel Richard Roberts
IPC分类号： C07F9/09 , C07C215/42
CPC分类号： C07D207/50 , C07B2200/07 , C07B2200/13 , C07C25/22 , C07C49/67 , C07C215/42 , C07C2601/08 , C07C2602/10 , C07F9/117
摘要： Disclosed are compounds of Formula (I) and/or a salt thereof; wherein R is —OH or —OP(O)(OH)2. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
摘要翻译： 公开了式（I）和/或其盐的化合物; 其中R是-OH或-OP（O）（OH）2。 还公开了使用这种化合物作为G蛋白偶联受体S1P1的选择性激动剂的方法，以及包含这些化合物的药物组合物。 这些化合物可用于治疗，预防或减缓各种治疗领域（例如自身免疫疾病和血管疾病）中的疾病或病症的进展。
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![[1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds](/abs-image/US/2024/04/23/USRE49931E1/abs.jpg.150x150.jpg)
公开(公告)号：USRE49931E1
公开(公告)日：2024-04-23
申请号：US17584147
申请日：2022-01-25
发明人： Alaric J. Dyckman , Dharmpal S. Dodd , Christopher P. Mussari , Laxman Pasunoori , Sreekantha Ratna Kumar
IPC分类号： A61K31/4196 , A61K31/437 , A61K31/4427 , A61K45/06 , C07D249/00 , C07D471/04
CPC分类号： A61K31/4196 , A61K31/437 , A61K31/4427 , A61K45/06 , C07D249/00 , C07D471/04
摘要： Disclosed are compounds of Formula (I)
or a salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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