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公开(公告)号：US20220213484A1
公开(公告)日：2022-07-07
申请号：US17594154
申请日：2020-04-02
Inventor： Brian R. ANDERSON , Richard E. OLSON , Ivar M. MCDONALD , Stephen E. MERCER , Peter HAGEDORN , Marianne Lerbech JENSEN
IPC: C12N15/113
Abstract: The present disclosure relates to antisense oligonucleotides, which target ANGPTL2 mRNA in a cell, leading to reduced expression of ANGPTL2 protein. Reduction of ANGPTL2 protein expression is beneficial for the treatment of certain medical disorders, such as those associated with abnormal ANGPTL2 expression and/or activity e.g., cardiovascular-related diseases or disorders.
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公开(公告)号：US20170129892A1
公开(公告)日：2017-05-11
申请号：US15317553
申请日：2015-06-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ivar M. MCDONALD , Richard E. OLSON , Robert A. MATE
IPC: C07D471/18 , C07D519/00
CPC classification number: C07D471/18 , C07D519/00
Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
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13.发明申请HETEROARYLENE-BRIDGED BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING 有权异丁烯二苯并二恶英二聚体，其结合物及其制备和使用方法公开(公告)号：US20170057959A1
公开(公告)日：2017-03-02
申请号：US15351955
申请日：2016-11-15
Applicant: Bristol-Myers Squibb Company
Inventor： Ivar M. MCDONALD , Naidu S. CHOWDARI , Walter Lewis JOHNSON , Yong ZHANG , Robert M. BORZILLERI , Sanjeev GANGWAR
IPC: C07D471/04
CPC classification number: C07D471/04 , A61K47/6803 , A61K47/6851 , A61K47/6889 , C07D487/04 , C07D519/00 , C07K5/06052
Abstract: Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
Abstract translation: 并且式（I），（Ia）和（Ib）中的其它变量如本申请中所定义。 这种二聚体可用作抗癌剂，特别是当用于抗体 - 药物偶联物（ADC）时。
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14.发明申请HETEROARYLENE-BRIDGED BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING 有权异丁烯二苯并二恶英二聚体，其结合物及其制备和使用方法公开(公告)号：US20160199510A1
公开(公告)日：2016-07-14
申请号：US14994378
申请日：2016-01-13
Applicant: Bristol-Myers Squibb Company
Inventor： Ivar M. MCDONALD , Naidu S. CHOWDARI , Walter Lewis Johnson , Yong Zhang , Robert M. BORZILLERI , Sanjeev Gangwar
IPC: A61K47/48 , C07K5/062 , C07D487/04
CPC classification number: C07D471/04 , A61K47/6803 , A61K47/6851 , A61K47/6889 , C07D487/04 , C07D519/00 , C07K5/06052
Abstract: Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
Abstract translation: 苯并二氮杂二聚体具有由其中X表示的结构，其包含杂芳族部分并且在本申请中进一步定义; R1和式（I），（Ia）和（Ib）中的其它变量如本申请中所定义。 这种二聚体可用作抗癌剂，特别是当用于抗体 - 药物偶联物（ADC）时。
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