公开(公告)号：US20200291016A1

公开(公告)日：2020-09-17

申请号：US16083958

申请日：2017-03-16

Applicant: Bristol-Myers Squibb Company

Inventor： Ellen K. Kick ,  Joanne M. Smalheer ,  Scott A. Shaw ,  Benjiman P. Vokits ,  Andrew K. Dilger ,  Charles G. Clark ,  Meriah Neissel Valente ,  Sutjano Jusuf ,  Nicholas R. Wurtz

IPC: C07D471/04 ,  C07D519/00

Abstract: The present invention provides compounds of Formula (I); wherein the substituents are each as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, and may be useful for the treatment and/or prophylaxis of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.

公开(公告)号：US10316035B2

公开(公告)日：2019-06-11

申请号：US15756373

申请日：2016-08-30

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Andrew Quoc Viet ,  Nicholas Ronald Wurtz ,  Scott A. Shaw ,  Ellen K. Kick ,  Andrew K. Dilger ,  Kumar Balashanmuga Pabbisetty

IPC: C07D471/04

Abstract: The present invention provides compounds of Formula (I): wherein A, Y and R1 are each as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.

公开(公告)号：US20190023701A1

公开(公告)日：2019-01-24

申请号：US15756367

申请日：2016-08-30

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Joanne M. Smallheer ,  Scott A. Shaw ,  Oz Scott Halpern ,  Carol Hui Hu ,  Ellen K. Kick

IPC: C07D471/04

CPC classification number: C07D471/04 ,  C07D487/08

Abstract: The present invention provides compounds of Formula (I): wherein A is as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.

公开(公告)号：US20180244671A1

公开(公告)日：2018-08-30

申请号：US15756373

申请日：2016-08-30

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Andrew Quoc Viet ,  Nicholas Ronald Wurtz ,  Scott A. Shaw ,  Ellen K. Kick ,  Andrew K. Dilger ,  Kumar Balashanmuga Pabbisetty

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: The present invention provides compounds of Formula (I): wherein A, Y and R1 are each as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.

公开(公告)号：US11008317B2

公开(公告)日：2021-05-18

申请号：US16083958

申请日：2017-03-16

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ellen K. Kick ,  Joanne M. Smallheer ,  Scott A. Shaw ,  Benjamin P. Vokits ,  Andrew K. Dilger ,  Charles G. Clark ,  Meriah Neissel Valente ,  Sutjano Jusuf ,  Nicholas R. Wurtz

IPC: C07D471/04 ,  C07D519/00

Abstract: The present invention provides compounds of Formula (I); wherein the substituents are each as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, and may be useful for the treatment and/or prophylaxis of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.

公开(公告)号：US10829501B2

公开(公告)日：2020-11-10

申请号：US16739363

申请日：2020-01-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Leon M. Smith, II ,  Vladimir Ladziata ,  Indawati DeLucca ,  Donald J. P. Pinto ,  Michael J. Orwat ,  Andrew K. Dilger ,  Kumar Balashanmuga Pabbisetty ,  Wu Yang ,  Scott A. Shaw ,  Peter W. Glunz ,  Manoranjan Panda

IPC: C07D513/04 ,  C07D213/64 ,  C07D231/18 ,  C07D471/04 ,  C07D471/12 ,  C07D413/12 ,  C07D401/12 ,  C07D231/54 ,  C07D401/14 ,  C07D231/12 ,  A61P15/10 ,  A61P9/10 ,  C07D239/06

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

公开(公告)号：US10407422B2

公开(公告)日：2019-09-10

申请号：US15756367

申请日：2016-08-30

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Joanne M. Smallheer ,  Scott A. Shaw ,  Oz Scott Halpern ,  Carol Hui Hu ,  Ellen K. Kick

IPC: C07D471/04 ,  C07D487/08

Abstract: The present invention provides compounds of Formula (I): wherein A is as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.

公开(公告)号：US10214527B2

公开(公告)日：2019-02-26

申请号：US15756378

申请日：2016-08-30

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Scott A. Shaw ,  Joanne M. Smallheer

IPC: C07D401/14 ,  A61K31/437 ,  C07D471/04

Abstract: The present invention provides compounds of Formula (I): wherein A is as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.

公开(公告)号：US20190016735A1

公开(公告)日：2019-01-17

申请号：US16067619

申请日：2017-01-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Leon M. Smith II ,  Vladimir Ladziata ,  Indawati De Lucca ,  Donald J.P. Pinto ,  Michael J. Orwat ,  Andrew K. Dilger ,  Kumar Balashanmuga Pabbisetty ,  Wu Yang ,  Scott A. Shaw ,  Peter W. Glunz ,  Manoranjan Panda

IPC: C07D513/04 ,  A61P9/10 ,  A61P15/10

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

公开(公告)号：US09920075B2

公开(公告)日：2018-03-20

申请号：US15510168

申请日：2015-09-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Nicholas R. Wurtz ,  Andrew Quoc Viet ,  Scott A. Shaw ,  Benjamin P. Vokits ,  Ellen K. Kick ,  Meriah Neissel Valente ,  Andrew K. Dilger ,  Kumar Balashanmuga Pabbisetty ,  Sutjano Jusuf

IPC: A61K31/519 ,  C07D519/00 ,  C07D471/04 ,  C07D487/04 ,  A61K31/437

CPC classification number: C07D519/00 ,  A61K31/437 ,  A61K31/519 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention provides compounds of Formula (I): wherein A and R1 are each as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.