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公开(公告)号：US20210155618A1
公开(公告)日：2021-05-27
申请号：US16629784
申请日：2018-07-11
发明人： Benjamin P. Vokits , Scott A. Shaw
IPC分类号： C07D471/04 , C07D401/12 , C07D401/14 , C07D487/04 , C07D405/14
摘要： The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
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公开(公告)号：US12060341B2
公开(公告)日：2024-08-13
申请号：US17888600
申请日：2022-08-16
发明人： Benjamin P. Vokits , Scott A. Shaw
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D471/04
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D471/04
摘要： The present invention provides compounds of Formula (I):
or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.-
公开(公告)号：US20200291015A1
公开(公告)日：2020-09-17
申请号：US16083951
申请日：2017-03-10
发明人： Joanne M. Smallheer , Carol Hui HU , Meriah Neissel Valente , Scott A. Shaw , Benjamin P. Vokits , Oz Scott Halpern
IPC分类号： C07D471/04
摘要： The present invention provides compounds of Formula (I). wherein A and Z are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and may be useful for the treatment and/or prophylaxis of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.
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公开(公告)号：US20200131200A1
公开(公告)日：2020-04-30
申请号：US16739363
申请日：2020-01-10
发明人： Leon M. Smith, II , Vladimir Ladziata , Indawati De Lucca , Donald J.P. Pinto , Michael J. Orwat , Andrew K. Dilger , Kumar Balashnmuga Pabbisetty , Wu Yang , Scott A. Shaw , Peter W. Glunz , Manoranjan Panda
IPC分类号： C07D513/04 , A61P9/10 , A61P15/10 , C07D213/64 , C07D231/12 , C07D401/14 , C07D231/54 , C07D401/12 , C07D413/12 , C07D471/12 , C07D471/04 , C07D231/18
摘要： The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
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公开(公告)号：US20240092755A1
公开(公告)日：2024-03-21
申请号：US17888600
申请日：2022-08-16
发明人： Benjamin P. Vokits , Scott A. Shaw
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D471/04
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D471/04
摘要： The present invention provides compounds of Formula (I):
or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.-
公开(公告)号：US11447487B2
公开(公告)日：2022-09-20
申请号：US16629784
申请日：2018-07-11
发明人： Benjamin P. Vokits , Scott A. Shaw
IPC分类号： C07D401/12 , C07D471/04 , C07D401/14 , C07D405/14 , C07D487/04
摘要： The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
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公开(公告)号：US20180282320A1
公开(公告)日：2018-10-04
申请号：US15756378
申请日：2016-08-30
发明人： Scott A. Shaw , Joanne M. Smallheer
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides compounds of Formula (I): wherein A is as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.
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公开(公告)号：US11059818B2
公开(公告)日：2021-07-13
申请号：US16083951
申请日：2017-03-10
发明人： Joanne M. Smallheer , Carol Hui Hu , Meriah Neissel Valente , Scott A. Shaw , Benjamin P. Vokits , Oz Scott Halpern
IPC分类号： C07D471/04
摘要： The present invention provides compounds of Formula (I). wherein A and Z are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and may be useful for the treatment and/or prophylaxis of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.
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公开(公告)号：US20200291016A1
公开(公告)日：2020-09-17
申请号：US16083958
申请日：2017-03-16
发明人： Ellen K. Kick , Joanne M. Smalheer , Scott A. Shaw , Benjiman P. Vokits , Andrew K. Dilger , Charles G. Clark , Meriah Neissel Valente , Sutjano Jusuf , Nicholas R. Wurtz
IPC分类号： C07D471/04 , C07D519/00
摘要： The present invention provides compounds of Formula (I); wherein the substituents are each as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, and may be useful for the treatment and/or prophylaxis of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.
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公开(公告)号：US10316035B2
公开(公告)日：2019-06-11
申请号：US15756373
申请日：2016-08-30
发明人： Andrew Quoc Viet , Nicholas Ronald Wurtz , Scott A. Shaw , Ellen K. Kick , Andrew K. Dilger , Kumar Balashanmuga Pabbisetty
IPC分类号： C07D471/04
摘要： The present invention provides compounds of Formula (I): wherein A, Y and R1 are each as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.
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