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公开(公告)号：US09199946B2
公开(公告)日：2015-12-01
申请号：US14390172
申请日：2013-03-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Jennifer X. Qiao , Carol Hui Hu , Tammy C. Wang , Ji Jiang
IPC: C07D403/12 , C07D239/545 , A61K31/505 , C07D239/557 , A61K31/4709 , C07D401/14 , C07D405/14 , C07D401/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D239/60 , C07D413/12 , C07D417/12 , C07D487/04 , C07D495/04
CPC classification number: C07D239/557 , A61K31/4709 , A61K31/505 , C07D239/60 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D495/04
Abstract: The present invention provides compounds of Formula (I), as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供了如说明书中所定义的式（I）化合物和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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2.发明申请公开(公告)号：US20150166538A1
公开(公告)日：2015-06-18
申请号：US14418011
申请日：2013-07-30
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Carl Thibeault , Charles G. Clark , Indawati DeLucca , Carol Hui Hu , Yoon Jeon , Patrick Y.S. Lam , Jennifer X. Qiao , Wu Yang , Yufeng Wang , Tammy C. Wang
IPC: C07D471/10 , C07D519/00
CPC classification number: C07D471/10 , C07D519/00
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are antagonists of P2Y1 receptor and may be used as medicaments in the treatment and/or prophylaxis of thromboembolic disorders.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是P2Y1受体的拮抗剂，可用作治疗和/或预防血栓栓塞障碍的药物。
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公开(公告)号：US20150065505A1
公开(公告)日：2015-03-05
申请号：US14390172
申请日：2013-03-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Jennifer X. Qiao , Carol Hui Hu , Tammy C. Wang , Ji Jiang
IPC: C07D239/557 , C07D495/04 , C07D487/04 , C07D417/12 , C07D401/14 , C07D401/12 , C07D403/12
CPC classification number: C07D239/557 , A61K31/4709 , A61K31/505 , C07D239/60 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D495/04
Abstract: The present invention provides compounds of Formula (I), as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供了如说明书中所定义的式（I）化合物和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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公开(公告)号：US20190177340A1
公开(公告)日：2019-06-13
申请号：US16099010
申请日：2017-06-26
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Joanne M. Smallheer , Ellen K. Kick , Meriah Neissel Valente , Carol Hui Hu , Oz Scott Halpern , Sutjano Jusuf
IPC: C07D519/00
CPC classification number: C07D519/00 , A61P9/10
Abstract: The present invention provides compounds of Formula (I): wherein the substituents are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, and may be useful for for the treatment and/or prophylaxis of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.
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公开(公告)号：US09394260B2
公开(公告)日：2016-07-19
申请号：US14390152
申请日：2013-04-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Carol Hui Hu , Jennifer X. Qiao , Tammy C. Wang
IPC: C07D401/12 , A61K31/513 , C07D239/557 , A61K31/5377 , C07D403/12 , C07D401/14 , C07D403/14 , C07D413/12 , C07D417/12 , C07D417/14
CPC classification number: C07D239/557 , A61K31/513 , A61K31/5377 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D417/12 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）化合物：如本说明书中所定义的（I）和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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Patent Agency Ranking
公开(公告)号：US20150361052A1
公开(公告)日：2015-12-17
申请号：US14390152
申请日：2013-04-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Carol Hui Hu , Jennifer X. Qiao , Tammy C. Wang
IPC: C07D239/557 , C07D401/12 , C07D417/14 , C07D413/12 , C07D401/14 , C07D403/14 , C07D403/12 , C07D417/12
CPC classification number: C07D239/557 , A61K31/513 , A61K31/5377 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D417/12 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）化合物：如本说明书中所定义的（I）和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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7.发明授权Amino-heteroaryl 7-hydroxy-spiropiperidine indolinyl antagonists of P2Y1 receptor 有权P2Y1受体的氨基 - 杂芳基7-羟基 - 螺哌啶二氢吲哚基拮抗剂公开(公告)号：US09120798B2
公开(公告)日：2015-09-01
申请号：US14417985
申请日：2013-07-29
Applicant: Bristol-Myers Squibb Company
Inventor： Jennifer X. Qiao , Carol Hui Hu , Carl Thibeault
IPC: C07D471/10 , C07D519/00
CPC classification number: C07D471/10 , C07D519/00
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are antagonists of P2Y1 receptor which may be used as medicaments.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的P2Y1受体的拮抗剂。
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公开(公告)号：US11059818B2
公开(公告)日：2021-07-13
申请号：US16083951
申请日：2017-03-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Joanne M. Smallheer , Carol Hui Hu , Meriah Neissel Valente , Scott A. Shaw , Benjamin P. Vokits , Oz Scott Halpern
IPC: C07D471/04
Abstract: The present invention provides compounds of Formula (I). wherein A and Z are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and may be useful for the treatment and/or prophylaxis of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.
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公开(公告)号：US20190023701A1
公开(公告)日：2019-01-24
申请号：US15756367
申请日：2016-08-30
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Joanne M. Smallheer , Scott A. Shaw , Oz Scott Halpern , Carol Hui Hu , Ellen K. Kick
IPC: C07D471/04
CPC classification number: C07D471/04 , C07D487/08
Abstract: The present invention provides compounds of Formula (I): wherein A is as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.
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10.发明授权公开(公告)号：US09120794B2
公开(公告)日：2015-09-01
申请号：US14575171
申请日：2014-12-18
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Lynn Abell , Leonard Adam , Cullen L. Cavallaro , Heather Finlay , Todd J. Friends , Jon J. Hangeland , Ji Jang , R. Michael Lawrence , John Lloyd , Zulan Pi , George O. Tora , Jennifer X. Qiao , Carol Hui Hu , Tammy C. Wang
IPC: C07D471/04 , C07D403/12 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/06 , C07D405/12 , C07D417/04 , C07D417/06 , C07D207/28 , C07D207/38 , C07D417/12 , C07D487/04 , C07D413/06
CPC classification number: C07D471/04 , C07D207/28 , C07D207/38 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12 , C07D487/04
Abstract: The present invention provides compounds of Formula (I) or Formula (III): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）或式（III）的化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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