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公开(公告)号：US20170342469A1
公开(公告)日：2017-11-30
申请号：US15527996
申请日：2015-11-11
Applicant: Battelle Memorial Institute
Inventor： Stephen R. Lindemann , Aaron T. Wright
IPC: C12Q1/68
Abstract: Methods and systems for identifying binding sites in macromolecules using small molecule mimics of naturally occurring molecules is disclosed. A reactive probe is provided that mimics small molecule cofactors. A target macromolecule is irreversibly bound to the probe in vivo to selectively pull down or precipitate probe-bound macromolecules. The macromolecules may be, but are not limited to, DNA, RNA, and proteins.
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