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公开(公告)号：US20220282317A1
公开(公告)日：2022-09-08
申请号：US17730004
申请日：2022-04-26
IPC分类号： C12Q1/6837 , C07K1/13 , C12Q1/6841 , C12Q1/48 , C07D311/16 , C07D405/04 , C07C233/33 , C07C233/20 , C07C247/00 , G01N33/58 , C07C305/22 , C07D203/26 , C07C247/12 , C07C203/04 , C07C271/28 , C07D405/12 , C07H19/067 , C07H15/203 , C12Q1/34 , C07C317/40
摘要： Activity-based probes that can be used to selectively identify and characterize enzymes that are involved in different phases of xenobiotic metabolism in a host and its microbiota population(s) are described. The activity-based probes described specifically label only their target active enzymes involved in xenobiotic metabolism and therefore provide a measurement of true protein functional activity rather than transcript or protein abundance. The activity-based probes also provide multimodal profiling of these active enzymes. Methods for preparing the activity based probes and exemplary methods for their use also are disclosed.
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公开(公告)号：US10731202B2
公开(公告)日：2020-08-04
申请号：US15527996
申请日：2015-11-11
IPC分类号： C12Q1/6809 , C12N15/10 , C12Q1/6816 , C12Q1/6869
摘要： Methods and systems for identifying binding sites in macromolecules using small molecule mimics of naturally occurring molecules is disclosed. A reactive probe is provided that mimics small molecule cofactors. A target macromolecule is irreversibly bound to the probe in vivo to selectively pull down or precipitate probe-bound macromolecules. The macromolecules may be, but are not limited to, DNA, RNA, and proteins.
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公开(公告)号：US20220235093A1
公开(公告)日：2022-07-28
申请号：US17469297
申请日：2021-09-08
摘要： Probe embodiments for targeting, identifying, and isolating enzymes exhibiting BSH activity as well as devices and kits that use the probes are described herein. Methods of making and using the probes, devices, and kits are also described. In some embodiments, probes, devices, and kits for targeting, identifying, and isolating enzymes in a biological sample are disclosed. In some embodiments, compositions and methods of treatment using the probes, devices, and kits disclosed herein are described.
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公开(公告)号：US11155573B2
公开(公告)日：2021-10-26
申请号：US16159429
申请日：2018-10-12
摘要： Probe embodiments for targeting, identifying, and isolating enzymes exhibiting BSH activity as well as devices and kits that use the probes are described herein. Methods of making and using the probes, devices, and kits are also described. In some embodiments, probes, devices, and kits for targeting, identifying, and isolating enzymes in a biological sample are disclosed. In some embodiments, compositions and methods of treatment using the probes, devices, and kits disclosed herein are described.
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公开(公告)号：US11891655B2
公开(公告)日：2024-02-06
申请号：US17730004
申请日：2022-04-26
IPC分类号： C12Q1/68 , C12Q1/6837 , C07K1/13 , C12Q1/6841 , C12Q1/48 , C07D311/16 , C07D405/04 , C07C233/33 , C07C233/20 , C07C247/00 , G01N33/58 , C07C305/22 , C07D203/26 , C07C247/12 , C07C203/04 , C07C271/28 , C07D405/12 , C07H19/067 , C07H15/203 , C12Q1/34 , C07C317/40
CPC分类号： C12Q1/6837 , C07C203/04 , C07C233/20 , C07C233/33 , C07C247/00 , C07C247/12 , C07C271/28 , C07C305/22 , C07C317/40 , C07D203/26 , C07D311/16 , C07D405/04 , C07D405/12 , C07H15/203 , C07H19/067 , C07K1/13 , C12Q1/34 , C12Q1/48 , C12Q1/6841 , G01N33/582 , G01N33/583 , C12Q2565/514 , C12Q2600/106 , G01N2333/91177
摘要： Activity-based probes that can be used to selectively identify and characterize enzymes that are involved in different phases of xenobiotic metabolism in a host and its microbiota population(s) are described. The activity-based probes described specifically label only their target active enzymes involved in xenobiotic metabolism and therefore provide a measurement of true protein functional activity rather than transcript or protein abundance. The activity-based probes also provide multimodal profiling of these active enzymes. Methods for preparing the activity based probes and exemplary methods for their use also are disclosed.
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6.发明授权公开(公告)号：US11169152B2
公开(公告)日：2021-11-09
申请号：US16132266
申请日：2018-09-14
IPC分类号： G01N33/573 , C12Q1/54 , C07H15/203 , G01N33/569
摘要： Probe embodiments for identifying analytes involved in biofuel or bioenergy production, bioremediation, or nutrient cycling as well as methods of making and use are described herein. In some embodiments, probes identifying cellulose degradation and/or sugar transport, lignin or chitin degradation, or peptide or toxin metabolism are included. In some embodiments, probes for identifying analytes in a soil sample are included in the compositions and methods disclosed herein.
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公开(公告)号：US20190112330A1
公开(公告)日：2019-04-18
申请号：US16159429
申请日：2018-10-12
摘要： Probe embodiments for targeting, identifying, and isolating enzymes exhibiting BSH activity as well as devices and kits that use the probes are described herein. Methods of making and using the probes, devices, and kits are also described. In some embodiments, probes, devices, and kits for targeting, identifying, and isolating enzymes in a biological sample are disclosed. In some embodiments, compositions and methods of treatment using the probes, devices, and kits disclosed herein are described.
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8.发明申请公开(公告)号：US20190086410A1
公开(公告)日：2019-03-21
申请号：US16132266
申请日：2018-09-14
IPC分类号： G01N33/573
摘要： Probe embodiments for identifying analytes involved in biofuel or bioenergy production, bioremediation, or nutrient cycling as well as methods of making and use are described herein. In some embodiments, probes identifying cellulose degradation and/or sugar transport, lignin or chitin degradation, or peptide or toxin metabolism are included. In some embodiments, probes for identifying analytes in a soil sample are included in the compositions and methods disclosed herein.
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公开(公告)号：US11345950B2
公开(公告)日：2022-05-31
申请号：US16151170
申请日：2018-10-03
IPC分类号： C12Q1/68 , C12Q1/6837 , C07K1/13 , C12Q1/6841 , C12Q1/48 , C07D311/16 , C07D405/04 , C07C233/33 , C07C233/20 , C07C247/00 , G01N33/58 , C07C305/22 , C07D203/26 , C07C247/12 , C07C203/04 , C07C271/28 , C07D405/12 , C07H19/067 , C07H15/203 , C12Q1/34 , C07C317/40
摘要： Activity-based probes that can be used to selectively identify and characterize enzymes that are involved in different phases of xenobiotic metabolism in a host and its microbiota population(s) are described. The activity-based probes described specifically label only their target active enzymes involved in xenobiotic metabolism and therefore provide a measurement of true protein functional activity rather than transcript or protein abundance. The activity-based probes also provide multimodal profiling of these active enzymes. Methods for preparing the activity based probes and exemplary methods for their use also are disclosed.
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10.发明申请公开(公告)号：US20190100792A1
公开(公告)日：2019-04-04
申请号：US16151170
申请日：2018-10-03
IPC分类号： C12Q1/6837 , C07K1/13 , C12Q1/6841
摘要： Activity-based probes that can be used to selectively identify and characterize enzymes that are involved in different phases of xenobiotic metabolism in a host and its microbiota population(s) are described. The activity-based probes described specifically label only their target active enzymes involved in xenobiotic metabolism and therefore provide a measurement of true protein functional activity rather than transcript or protein abundance. The activity-based probes also provide multimodal profiling of these active enzymes. Methods for preparing the activity based probes and exemplary methods for their use also are disclosed.
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