公开(公告)号：US09918969B2

公开(公告)日：2018-03-20

申请号：US15332893

申请日：2016-10-24

申请人： Bayer Pharma Aktiengesellschaft

发明人： Susanne Röhrig ,  Alexander Hillisch ,  Julia Straβburger ,  Stefan Heitmeier ,  Martina Victoria Schmidt ,  Karl-Heinz Schlemmer ,  Anja Buchmüller ,  Christoph Gerdes ,  Henrik Teller ,  Martina Schäfer ,  Adrian Tersteegen

IPC分类号： A61K31/438 ,  A61K31/437 ,  C07D215/227 ,  C07D221/04 ,  C07D401/12 ,  C07D413/12 ,  C07D471/04

CPC分类号： A61K31/438 ,  A61K31/437 ,  C07D215/227 ,  C07D221/04 ,  C07D401/12 ,  C07D413/12 ,  C07D471/04

摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

公开(公告)号：US09822102B2

公开(公告)日：2017-11-21

申请号：US15256608

申请日：2016-09-04

申请人： Bayer Pharma Aktiengesellschaft

发明人： Susanne Röhrig ,  Alexander Hillisch ,  Julia Strassburger ,  Stefan Heitmeier ,  Martina Victoria Schmidt ,  Karl-Heinz Schlemmer ,  Adrian Tersteegen ,  Anja Buchmüller ,  Christoph Gerdes ,  Martina Schäfer ,  Tom Kinzel ,  Henrik Teller ,  Hartmut Schirok ,  Jürgen Klar ,  Eloisa Jimenez Nunez

IPC分类号： C07D413/06 ,  A61K31/4418 ,  A61K31/4412 ,  C07D405/06 ,  C07D413/14 ,  C07D213/85 ,  C07D401/12 ,  C07D409/06 ,  C07D413/12 ,  C07D417/12 ,  C07D213/64 ,  C07D213/69 ,  C07D213/84

CPC分类号： C07D405/06 ,  C07B2200/05 ,  C07D213/64 ,  C07D213/69 ,  C07D213/84 ,  C07D213/85 ,  C07D401/12 ,  C07D409/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

公开(公告)号：US20150099298A1

公开(公告)日：2015-04-09

申请号：US14400281

申请日：2013-05-08

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Andreas Wilmen ,  Julia Straßburger ,  Frank Dittmer ,  Michael Strerath ,  Anja Buchmüller ,  Joanna Grudzinska-Goebel ,  Ricarda Finnern ,  Martina Schäfer ,  Christoph Gerdes ,  Hannah Jörißen ,  Asako Itakura ,  Philberta Leung ,  Erik Tucker

IPC分类号： C07K16/36

CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76

摘要： The present invention relates to antibodies capable of binding to the coagulation Factor XI and/or its activated form factor XIa and methods of use thereof, particularly methods of use as agents inhibiting platelet aggregation and by this inhibits thrombus formation.

摘要翻译： 本发明涉及能够结合凝血因子XI和/或其活化形式因子XIa的抗体及其使用方法，特别是用作抑制血小板聚集的药物的方法，并且由此抑制血栓形成。