公开(公告)号：US20230226217A1

公开(公告)日：2023-07-20

申请号：US18071705

申请日：2022-11-30

Applicant: TRON-Translationale Onkologie an der Universitatsmedizin der Johannes Gutenberg-Universitat Mainz ad ,  BioNTech SE

Inventor： Ugur Sahin ,  Heinrich Haas ,  Sebastian Kreiter ,  Mustafa Diken ,  Daniel Fritz ,  Martin Meng ,  Lena Mareen Kranz ,  Kerstin Reuter

IPC: A61K48/00 ,  A61K39/00 ,  A61K9/127

CPC classification number: A61K48/0033 ,  A61K9/1272 ,  A61K39/0011 ,  A61K48/0025 ,  A61K2039/53 ,  A61K2039/55555

Abstract: The present invention is in the field of immunotherapy, in particular tumor immunotherapy. The present invention provides pharmaceutical formulations for delivering RNA to antigen presenting cells such as dendrite cells (DCs) in the spleen after systemic administration. In particular, the formulations described herein enable to induce an immune response after systemic administration of antigen-coding RNA.

公开(公告)号：US11660338B2

公开(公告)日：2023-05-30

申请号：US16749012

申请日：2020-01-22

Applicant: BIONTECH SE ,  TRON-TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITATSMEDIZIN DER JOHANNES Gutenberg-Universitat Mainz Gemeinnutzige GmbH

Inventor： Ugur Sahin ,  Heinrich Haas ,  Sebastian Kreiter ,  Yves Hüsemann ,  Mustafa Diken ,  Kerstin Reuter ,  Hossam Hefesha

IPC: A61K39/39 ,  C12N15/88 ,  A61K9/50 ,  A61K9/127 ,  A61K31/675 ,  A61K39/00

CPC classification number: A61K39/39 ,  A61K9/1271 ,  A61K9/1277 ,  A61K9/5073 ,  A61K31/675 ,  A61K39/0011 ,  C12N15/88 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/572 ,  C12N2810/10

Abstract: The present invention relates to RNA decorated particles such as RNA decorated lipid particles, preferably to RNA decorated liposomes. Further, the present invention relates to a pharmaceutical composition comprising RNA decorated particles such as RNA decorated lipid particles, preferably RNA decorated liposomes. Said pharmaceutical composition is useful for inducing an immune response. It is also useful in a prophylactic and/or therapeutic treatment of a disease involving an antigen. Furthermore, the present invention relates to a method for producing the RNA decorated particles such as RNA decorated lipid particles, preferably RNA decorated liposomes.

公开(公告)号：US20220313811A1

公开(公告)日：2022-10-06

申请号：US17717645

申请日：2022-04-11

Applicant: BIONTECH SE ,  TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ

Inventor： Ugur Sahin ,  Heinrich Haas ,  Annette Vogel ,  Daniel Zucker ,  Stephanie Erbar ,  Kerstin Walzer ,  Anne Schlegel ,  Sebastian Hörner ,  Sebastian Kreiter ,  Mustafa Diken ,  Jorge Moreno Herrero

IPC: A61K39/12 ,  A61K9/00 ,  A61K9/19 ,  A61K47/18 ,  A61K47/26 ,  A61K47/34

Abstract: The present invention relates to compositions comprising polyplex formulations for delivery of RNA to a target organ or a target cell after parenteral administration, in particular after intramuscular administration. More precisely, the present invention relates to formulations for administration of RNA such as self-replicating RNA, in particular by intramuscular injection. In more detail, the formulations comprise polyplex particles from single stranded RNA and a polyalkyleneimine. The RNA may encode a protein of interest, such as a pharmaceutically active protein. Furthermore, the present invention relates to pharmaceutical products, comprising said RNA polyplex formulations for parenteral application to humans or to animals. The present invention relates as well to manufacturing of such pharmaceutical products, comprising, optionally, steps of sterile filtration, freezing and dehydration.

公开(公告)号：US11248264B2

公开(公告)日：2022-02-15

申请号：US16920286

申请日：2020-07-02

Applicant: TRON-Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz gGmbH ,  BioNTech SE

Inventor： Ugur Sahin ,  Sebastian Kreiter ,  Mustafa Diken ,  Jan Diekmann ,  Michael Koslowski ,  Cedrik Britten ,  John Christopher Castle ,  Martin Löwer ,  Bernhard Renard ,  Tana Omokoko ,  Johannes Hendrikus De Graaf

IPC: A61K39/00 ,  C12Q1/6869 ,  G16B20/00 ,  G16B40/00 ,  C12Q1/6886 ,  G16B20/20

Abstract: The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.