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33 条记录 (耗时 0.04 秒)

    Tricyclic compounds and uses thereof
    13.
    发明授权
    Tricyclic compounds and uses thereof 失效
    三环化合物及其用途

    公开(公告)号：US06723736B2

    公开(公告)日：2004-04-20

    申请号：US09973190

    申请日：2001-10-10

    申请人： Debendranath Dey ,  Partha Neogi ,  Ananda Sen ,  Somesh D. Sharma ,  Bishwajit Nag

    发明人： Debendranath Dey ,  Partha Neogi ,  Ananda Sen ,  Somesh D. Sharma ,  Bishwajit Nag

    IPC分类号： A61K3134

    CPC分类号： C07D335/06 ,  C07D217/16 ,  C07D217/24 ,  C07D311/76

    摘要： Substituted isoquinolines, isochromanones and isothiochromanones that inhibit the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-6 (IL-6) and/or the enzyme cyclooxygenase-2 (COX-2) and/or interleukin-10 (IL-10). Compositions containing such compounds and methods of using such compounds for treatment and/or prevention of inflammation, inflammatory diseases, immunologic diseases and other diseases mediated by TNF-alpha, IL-6, COX-2 and/or IL-10 are also disclosed.

    摘要翻译： 抑制促炎细胞因子肿瘤坏死因子-α（TNF-α）和/或白细胞介素-6（IL-6）和/或酶环加氧酶-2（COX-2）和/或其他细胞因子的替代异喹啉，异色满酮和异硫代色酮 白细胞介素-10（IL-10）。 还公开了含有这些化合物的组合物和使用这些化合物治疗和/或预防炎症，炎性疾病，免疫疾病和由TNF-α，IL-6，COX-2和/或IL-10介导的其它疾病的方法。

    Novel heterocyclic analogs of diphenylethylene compounds
    14.
    发明申请
    Novel heterocyclic analogs of diphenylethylene compounds 失效
    二苯基乙烯化合物的新型杂环类似物

    公开(公告)号：US20080293949A1

    公开(公告)日：2008-11-27

    申请号：US12078662

    申请日：2008-04-02

    申请人： Partha Neogi ,  Debendranath Dey ,  Satyanarayana Medicherla ,  Bishwajit Nag ,  Arthur Lee

    发明人： Partha Neogi ,  Debendranath Dey ,  Satyanarayana Medicherla ,  Bishwajit Nag ,  Arthur Lee

    IPC分类号： C07D277/14

    CPC分类号： C07D277/20 ,  C07D277/24 ,  C07D277/34

    摘要： Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis.

    摘要翻译： 提供了含有噻唑烷二酮或恶唑烷二酮部分的新型二苯基乙烯化合物及其衍生物，其有效降低II型糖尿病动物模型中的血糖水平，血清胰岛素，甘油三酯和游离脂肪酸水平。 所述化合物被公开用于各种治疗，包括治疗炎症，炎症和免疫疾病，胰岛素抵抗，高脂血症，冠状动脉疾病，癌症和多发性硬化。

    Heterocyclic analogs of diphenylethylene compounds
    15.
    发明授权
    Heterocyclic analogs of diphenylethylene compounds 失效
    二苯基乙烯化合物的杂环类似物

    公开(公告)号：US07202366B2

    公开(公告)日：2007-04-10

    申请号：US10808519

    申请日：2004-03-25

    申请人： Bishwajit Nag ,  Debendranath Dey ,  Satyanarayana Medicherla ,  Partha Neogi

    发明人： Bishwajit Nag ,  Debendranath Dey ,  Satyanarayana Medicherla ,  Partha Neogi

    IPC分类号： A61K31/41 ,  C07D277/60

    CPC分类号： C07D277/20 ,  C07D277/24 ,  C07D277/34

    摘要： Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. In contrast to previously reported thiazolidinedione compounds, known to lower leptin levels, the present compounds increase leptin levels and have no known liver toxicity. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis.

    摘要翻译： 提供了含有噻唑烷二酮或恶唑烷二酮部分的新型二苯基乙烯化合物及其衍生物，其有效降低II型糖尿病动物模型中的血糖水平，血清胰岛素，甘油三酯和游离脂肪酸水平。 与之前报道的已知降低瘦蛋白水平的噻唑烷二酮化合物相比，本发明化合物增加瘦素水平并且没有已知的肝脏毒性。 所述化合物被公开用于各种治疗，包括治疗炎症，炎症和免疫疾病，胰岛素抵抗，高脂血症，冠状动脉疾病，癌症和多发性硬化。

    Heterocyclic analogs of diphenylethylene compounds
    18.
    发明授权
    Heterocyclic analogs of diphenylethylene compounds 失效
    二苯基乙烯化合物的杂环类似物

    公开(公告)号：US07407978B2

    公开(公告)日：2008-08-05

    申请号：US10265902

    申请日：2002-10-08

    申请人： Partha Neogi ,  Debendranath Dey ,  Satyanarayana Medicheria ,  Bishwajit Nag ,  Arthur Lee

    发明人： Partha Neogi ,  Debendranath Dey ,  Satyanarayana Medicheria ,  Bishwajit Nag ,  Arthur Lee

    IPC分类号： A61K31/425

    CPC分类号： C07D277/20 ,  C07D277/24 ,  C07D277/34

    摘要： Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis.

    摘要翻译： 提供了含有噻唑烷二酮或恶唑烷二酮部分的新型二苯基乙烯化合物及其衍生物，其有效降低II型糖尿病动物模型中的血糖水平，血清胰岛素，甘油三酯和游离脂肪酸水平。 所述化合物被公开用于各种治疗，包括治疗炎症，炎症和免疫疾病，胰岛素抵抗，高脂血症，冠状动脉疾病，癌症和多发性硬化。