公开(公告)号：US11622803B2

公开(公告)日：2023-04-11

申请号：US16838617

申请日：2020-04-02

Applicant: Boston Scientific Scimed, Inc.

Inventor： Steven R. Mickelsen ,  Raju Viswanathan ,  Allan Zingeler

IPC: A61B18/14 ,  A61B17/08 ,  A61B18/00 ,  A61B90/00

Abstract: Systems, tools and methods are disclosed for the selective and rapid application of DC voltage to drive irreversible electroporation, with the system controller capable of being configured to apply voltages to independently selected subsets of electrodes and capable of generating at least one control signal to maintain the temperature near an electrode head within a desired range of values. Electrode clamp devices are also disclosed for generating electric fields to drive irreversible electroporation while modulating temperature to elevate the irreversible electroporation threshold utilizing a variety of means such as cooling fluid or solid state thermoelectric heat pumps.

公开(公告)号：US20220133405A1

公开(公告)日：2022-05-05

申请号：US17575228

申请日：2022-01-13

Applicant: Boston Scientific Scimed, Inc.

Inventor： Steven R. Mickelsen

IPC: A61B18/14 ,  A61B18/12 ,  A61B18/00

Abstract: Catheter systems, tools and methods are disclosed for the selective and rapid application of DC voltage pulses to drive irreversible electroporation for minimally invasive transurethral prostate ablation. In one embodiment, a switch unit is used to modulate and apply voltage pulses from a cardiac defibrillator, while in another, the system controller can be configured to apply voltages to an independently selected multiplicity or subsets of electrodes. Devices are disclosed for more effective DC voltage application including the infusion of cooled fluid to elevate the irreversible electroporation threshold of urethral wall tissue and to selectively ablate regions of prostate tissue alone.