公开(公告)号：US20240307117A1

公开(公告)日：2024-09-19

申请号：US18674613

申请日：2024-05-24

Applicant: Boston Scientific Scimed, Inc.

Inventor： Steven R. Mickelsen

IPC: A61B18/14 ,  A61B5/0538 ,  A61B17/00 ,  A61B18/00 ,  A61B18/12 ,  A61B18/18 ,  A61N1/04 ,  A61N1/32 ,  A61N7/02

CPC classification number: A61B18/1492 ,  A61B5/0538 ,  A61N1/327 ,  A61N7/022 ,  A61B2017/00026 ,  A61B2017/00154 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00404 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00654 ,  A61B2018/00827 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/00994 ,  A61B2018/124 ,  A61B2018/1467 ,  A61B18/1815 ,  A61B2218/002 ,  A61B2576/023 ,  A61N1/0412

Abstract: Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.

公开(公告)号：US20240307115A1

公开(公告)日：2024-09-19

申请号：US18674565

申请日：2024-05-24

Applicant: Boston Scientific Scimed, Inc.

Inventor： Steven R. Mickelsen

IPC: A61B18/14 ,  A61B5/0538 ,  A61B17/00 ,  A61B18/00 ,  A61B18/12 ,  A61B18/18 ,  A61N1/04 ,  A61N1/32 ,  A61N7/02

CPC classification number: A61B18/1492 ,  A61B5/0538 ,  A61N1/327 ,  A61N7/022 ,  A61B2017/00026 ,  A61B2017/00154 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00404 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00654 ,  A61B2018/00827 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/00994 ,  A61B2018/124 ,  A61B2018/1467 ,  A61B18/1815 ,  A61B2218/002 ,  A61B2576/023 ,  A61N1/0412

Abstract: Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.

公开(公告)号：US20250099175A1

公开(公告)日：2025-03-27

申请号：US18974379

申请日：2024-12-09

Applicant: Boston Scientific Scimed, Inc.

Inventor： Steven R. Mickelsen

IPC: A61B18/14 ,  A61B18/00 ,  A61B18/12

Abstract: Catheter systems, tools and methods are disclosed for the selective and rapid application of DC voltage pulses to drive irreversible electroporation for minimally invasive transurethral prostate ablation. In one embodiment, a switch unit is used to modulate and apply voltage pulses from a cardiac defibrillator, while in another, the system controller can be configured to apply voltages to an independently selected multiplicity or subsets of electrodes. Devices are disclosed for more effective DC voltage application including the infusion of cooled fluid to elevate the irreversible electroporation threshold of urethral wall tissue and to selectively ablate regions of prostate tissue alone.

公开(公告)号：US20240315769A1

公开(公告)日：2024-09-26

申请号：US18674492

申请日：2024-05-24

Applicant: Boston Scientific Scimed, Inc.

Inventor： Steven R. Mickelsen

IPC: A61B18/14 ,  A61B5/0538 ,  A61B17/00 ,  A61B18/00 ,  A61B18/12 ,  A61B18/18 ,  A61N1/04 ,  A61N1/32 ,  A61N7/02

CPC classification number: A61B18/1492 ,  A61B5/0538 ,  A61N1/327 ,  A61N7/022 ,  A61B2017/00026 ,  A61B2017/00154 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00404 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00654 ,  A61B2018/00827 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/00994 ,  A61B2018/124 ,  A61B2018/1467 ,  A61B18/1815 ,  A61B2218/002 ,  A61B2576/023 ,  A61N1/0412

Abstract: Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.

公开(公告)号：US20240315770A1

公开(公告)日：2024-09-26

申请号：US18674533

申请日：2024-05-24

Applicant: Boston Scientific Scimed, Inc.

Inventor： Steven R. Mickelsen

IPC: A61B18/14 ,  A61B5/0538 ,  A61B17/00 ,  A61B18/00 ,  A61B18/12 ,  A61B18/18 ,  A61N1/04 ,  A61N1/32 ,  A61N7/02

CPC classification number: A61B18/1492 ,  A61B5/0538 ,  A61N1/327 ,  A61N7/022 ,  A61B2017/00026 ,  A61B2017/00154 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00404 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00654 ,  A61B2018/00827 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/00994 ,  A61B2018/124 ,  A61B2018/1467 ,  A61B18/1815 ,  A61B2218/002 ,  A61B2576/023 ,  A61N1/0412

Abstract: Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.

公开(公告)号：US20240307116A1

公开(公告)日：2024-09-19

申请号：US18674607

申请日：2024-05-24

Applicant: Boston Scientific Scimed, Inc.

Inventor： Steven R. Mickelsen

IPC: A61B18/14 ,  A61B5/0538 ,  A61B17/00 ,  A61B18/00 ,  A61B18/12 ,  A61B18/18 ,  A61N1/04 ,  A61N1/32 ,  A61N7/02

CPC classification number: A61B18/1492 ,  A61B5/0538 ,  A61N1/327 ,  A61N7/022 ,  A61B2017/00026 ,  A61B2017/00154 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00404 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00654 ,  A61B2018/00827 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/00994 ,  A61B2018/124 ,  A61B2018/1467 ,  A61B18/1815 ,  A61B2218/002 ,  A61B2576/023 ,  A61N1/0412

Abstract: Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.

公开(公告)号：US20240299089A1

公开(公告)日：2024-09-12

申请号：US18664163

申请日：2024-05-14

Applicant: Boston Scientific Scimed, Inc.

Inventor： Steven R. Mickelsen

IPC: A61B18/14 ,  A61B5/0538 ,  A61B17/00 ,  A61B18/00 ,  A61B18/12 ,  A61B18/18 ,  A61N1/04 ,  A61N1/32 ,  A61N7/02

CPC classification number: A61B18/1492 ,  A61B5/0538 ,  A61N1/327 ,  A61N7/022 ,  A61B2017/00026 ,  A61B2017/00154 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00404 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00654 ,  A61B2018/00827 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/00994 ,  A61B2018/124 ,  A61B2018/1467 ,  A61B18/1815 ,  A61B2218/002 ,  A61B2576/023 ,  A61N1/0412

Abstract: Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.

公开(公告)号：US20240307114A1

公开(公告)日：2024-09-19

申请号：US18674511

申请日：2024-05-24

Applicant: Boston Scientific Scimed, Inc.

Inventor： Steven R. Mickelsen

IPC: A61B18/14 ,  A61B5/0538 ,  A61B17/00 ,  A61B18/00 ,  A61B18/12 ,  A61B18/18 ,  A61N1/04 ,  A61N1/32 ,  A61N7/02

CPC classification number: A61B18/1492 ,  A61B5/0538 ,  A61N1/327 ,  A61N7/022 ,  A61B2017/00026 ,  A61B2017/00154 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00404 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00654 ,  A61B2018/00827 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/00994 ,  A61B2018/124 ,  A61B2018/1467 ,  A61B18/1815 ,  A61B2218/002 ,  A61B2576/023 ,  A61N1/0412

Abstract: Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.

公开(公告)号：US20240299088A1

公开(公告)日：2024-09-12

申请号：US18664140

申请日：2024-05-14

Applicant: Boston Scientific Scimed, Inc.

Inventor： Steven R. Mickelsen

IPC: A61B18/14 ,  A61B5/0538 ,  A61B17/00 ,  A61B18/00 ,  A61B18/12 ,  A61B18/18 ,  A61N1/04 ,  A61N1/32 ,  A61N7/02

CPC classification number: A61B18/1492 ,  A61B5/0538 ,  A61N1/327 ,  A61N7/022 ,  A61B2017/00026 ,  A61B2017/00154 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00404 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00654 ,  A61B2018/00827 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/00994 ,  A61B2018/124 ,  A61B2018/1467 ,  A61B18/1815 ,  A61B2218/002 ,  A61B2576/023 ,  A61N1/0412

Abstract: Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.

公开(公告)号：US12161397B2

公开(公告)日：2024-12-10

申请号：US17575228

申请日：2022-01-13

Applicant: Boston Scientific Scimed, Inc.

Inventor： Steven R. Mickelsen

IPC: A61B18/14 ,  A61B18/12 ,  A61B18/00

Abstract: Catheter systems, tools and methods are disclosed for the selective and rapid application of DC voltage pulses to drive irreversible electroporation for minimally invasive transurethral prostate ablation. In one embodiment, a switch unit is used to modulate and apply voltage pulses from a cardiac defibrillator, while in another, the system controller can be configured to apply voltages to an independently selected multiplicity or subsets of electrodes. Devices are disclosed for more effective DC voltage application including the infusion of cooled fluid to elevate the irreversible electroporation threshold of urethral wall tissue and to selectively ablate regions of prostate tissue alone.