公开(公告)号：US20190185463A1

公开(公告)日：2019-06-20

申请号：US16046268

申请日：2018-07-26

Applicant: CHDI Foundation, Inc.

Inventor： Michel C. Maillard ,  Perla Breccia ,  Celia Dominguez ,  Alan F. Haughan ,  Rebecca E. Jarvis ,  Christopher A. Luckhurst ,  Elizabeth A. Saville-Stones ,  Andrew J. Stott ,  Amanda Van de Poël ,  Michael Wall ,  Grant Wishart

IPC: C07D413/12 ,  C07D491/107

CPC classification number: C07D413/12 ,  C07D491/107

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.

公开(公告)号：US10105363B2

公开(公告)日：2018-10-23

申请号：US15411535

申请日：2017-01-20

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Vahri Beaumont ,  Ignacio Muñoz-Sanjuán ,  Roland W. Bürli ,  Alan F. Haughan ,  Christopher A. Luckhurst ,  Michael Wall ,  Gilles Raphy ,  Beth Thomas

IPC: A61K31/505 ,  C07D239/26

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.

公开(公告)号：US10053434B2

公开(公告)日：2018-08-21

申请号：US15148907

申请日：2016-05-06

Applicant: CHDI Foundation, Inc.

Inventor： Michel C. Maillard ,  Perla Breccia ,  Celia Dominguez ,  Alan F. Haughan ,  Amanda Van de Poël ,  Andrew J. Stott ,  Christopher A. Luckhurst ,  Elizabeth A. Saville-Stones ,  Grant Wishart ,  Michael Wall ,  Rebecca E. Jarvis

IPC: C07D413/12 ,  C07D271/06 ,  C07D471/04

CPC classification number: C07D271/06 ,  C07D413/12 ,  C07D471/04

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.

公开(公告)号：US20170101402A1

公开(公告)日：2017-04-13

申请号：US15315713

申请日：2015-06-01

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Ignacio Muñoz-Sanjuán ,  Christopher A. Luckhurst ,  Daniel R. Allen ,  Gilles Raphy ,  Roland W. Bürli ,  Perla Breccia ,  Alan F. Haughan ,  Grant Wishart ,  Samantha J. Hughes ,  Rebeca E. Jarvis ,  Huw D. Vater ,  Stephen D. Penrose ,  Michael Wall ,  Andrew J. Stott ,  Elizabeth A. Saville-Stones

IPC: C07D417/04 ,  C07D401/04 ,  C07D403/04 ,  C07C259/08 ,  C07D239/88 ,  C07D277/60 ,  C07D239/70 ,  C07D231/54 ,  C07D231/56

CPC classification number: C07D417/04 ,  C07C259/08 ,  C07D231/54 ,  C07D231/56 ,  C07D239/70 ,  C07D239/74 ,  C07D239/88 ,  C07D275/04 ,  C07D277/60 ,  C07D401/04 ,  C07D403/04

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, or pharmaceutically acceptable salts thereof, compositions thereof, and methods of their use. The condition or disorder mediated by HDAC comprises a neurodegenerative pathology. Accordingly, also provided is a method of treating a neurodegenerative pathology mediated by HDAC in a subject in need of such a treatment, comprising administering to the subject a therapeutically effective amount of at least one compound, or pharmaceutically acceptable salt thereof, described herein.

公开(公告)号：US09617259B2

公开(公告)日：2017-04-11

申请号：US14776320

申请日：2014-03-10

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Ignacio Muñoz-Sanjuán ,  Michel Maillard ,  Christopher A. Luckhurst ,  Rebecca E. Jarvis ,  Roland W. Bürli ,  Daniel R. Allen ,  Alan F. Haughan ,  Perla Breccia ,  Huw D. Vater ,  Andrew J. Stott ,  Stephen D. Penrose ,  Michael Wall ,  Elizabeth A. Saville-Stones ,  Grant Wishart ,  Samantha J. Hughes

IPC: C07D471/04 ,  C07D277/64 ,  C07D241/12 ,  C07D213/64 ,  C07C259/08 ,  C07D277/62 ,  C07D261/20 ,  C07D275/04 ,  C07D333/60 ,  C07D213/56 ,  C07D213/61 ,  C07D239/26 ,  C07D241/42 ,  C07D231/12 ,  C07D231/56

CPC classification number: C07D471/04 ,  C07C259/08 ,  C07C2601/02 ,  C07C2601/10 ,  C07D213/56 ,  C07D213/61 ,  C07D213/64 ,  C07D231/12 ,  C07D231/56 ,  C07D239/26 ,  C07D241/12 ,  C07D241/42 ,  C07D261/20 ,  C07D275/04 ,  C07D277/62 ,  C07D277/64 ,  C07D333/60

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.

公开(公告)号：US20190202795A1

公开(公告)日：2019-07-04

申请号：US16046254

申请日：2018-07-26

Applicant: CHDI Foundation, Inc.

Inventor： Michel C. Maillard ,  Perla Breccia ,  Celia Dominguez ,  Alan F. Haughan ,  Amanda Van de Poël ,  Andrew J. Stott ,  Christopher A. Luckhurst ,  Elizabeth A. Saville-Stones ,  Grant Wishart ,  Michael Wall ,  Rebecca E. Jarvis

IPC: C07D271/06 ,  C07D413/12 ,  C07D471/04

CPC classification number: C07D271/06 ,  C07D413/12 ,  C07D471/04

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.

公开(公告)号：US10106535B2

公开(公告)日：2018-10-23

申请号：US15482327

申请日：2017-04-07

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Ignacio Muñoz-Sanjuán ,  Michel Maillard ,  Christopher A. Luckhurst ,  Rebecca E. Jarvis ,  Roland W. Bürli ,  Daniel R. Allen ,  Alan F. Haughan ,  Perla Breccia ,  Huw D. Vater ,  Andrew J. Stott ,  Stephen D. Penrose ,  Michael Wall ,  Elizabeth A. Saville-Stones ,  Grant Wishart ,  Samantha J. Hughes

IPC: C07D471/04 ,  C07C259/08 ,  C07D277/64 ,  C07D231/12 ,  C07D231/56 ,  C07D261/20 ,  C07D241/12 ,  C07D239/26 ,  C07D213/61 ,  C07D333/60 ,  C07D275/04 ,  C07D213/64 ,  C07D277/62 ,  C07D241/42 ,  C07D213/56

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.

公开(公告)号：US20160326124A1

公开(公告)日：2016-11-10

申请号：US15148907

申请日：2016-05-06

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Michel C. Maillard ,  Alan F. Haughan ,  Amanda Van de Poël ,  Andrew J. Stott ,  Christopher A. Luckhurst ,  Elizabeth A. Saville-Stones ,  Grant Wishart ,  Michael Wall ,  Perla Breccia ,  Rebecca E. Jarvis

IPC: C07D271/06 ,  C07D471/04 ,  C07D413/12

CPC classification number: C07D271/06 ,  C07D413/12 ,  C07D471/04

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.