公开(公告)号：US10189844B2

公开(公告)日：2019-01-29

申请号：US15420513

申请日：2017-01-31

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Matteo Biagetti ,  Anna Maria Capelli ,  Michele Retini

IPC: C07D487/04 ,  A61K31/519 ,  A61K45/06

Abstract: Compounds of formula (I) defined herein are phosphoinositide 3-kinases (PI3K) inhibitors and are useful for the treatment of disorders associated with PI3K enzymes.

公开(公告)号：US09968604B2

公开(公告)日：2018-05-15

申请号：US15079740

申请日：2016-03-24

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Anna Maria Capelli ,  Matteo Biagetti ,  Alessandro Accetta

IPC: A61K31/519 ,  A61K31/52 ,  C07D403/12 ,  C07D405/12 ,  C07D473/34 ,  C07D487/04 ,  A61K31/506

CPC classification number: A61K31/506 ,  A61K31/519 ,  A61K31/52 ,  C07D403/12 ,  C07D405/12 ,  C07D473/34 ,  C07D487/04

Abstract: Chromene compounds of formula (I), defined herein, inhibit phosphoinositide 3-kinases (PI3K) and are useful for the treatment of disorders associated with a PI3K enzyme mechanism, such as asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis.