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公开(公告)号：US20180215758A1
公开(公告)日：2018-08-02
申请号：US15883729
申请日：2018-01-30
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Alessandro Accetta , Fabio Rancati , Anna Maria Capelli , David Edward Clark , Patrizia Tisselli , Christine Edwards , Gurdip Bhalay , Arnaud Jean Francois Auguste Cheguillaume
IPC: C07D471/04 , C07D498/04 , C07D471/08 , A61K31/437 , A61K31/519 , A61K31/5377 , A61K31/5383 , A61K31/4375 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/444 , A61K31/439 , A61K31/501 , A61K31/498 , A61K9/00
Abstract: Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be used for the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
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公开(公告)号：US09745308B2
公开(公告)日：2017-08-29
申请号：US14840420
申请日：2015-08-31
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Matteo Biagetti , Anna Maria Capelli , Matilde Guala
IPC: C07D473/34 , C07D403/12 , A61K31/5377 , A61K31/52 , A61K31/519 , A61K31/506 , C07D487/04
CPC classification number: C07D487/04 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/5377 , C07D403/12 , C07D473/34 , Y02A50/409
Abstract: Compounds of formula (I) described herein inhibit phosphoinositide 3-kinases (PI3K) and useful for the treatment of disorders associated with PI3K enzymes.
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公开(公告)号：US11147812B2
公开(公告)日：2021-10-19
申请号：US16639486
申请日：2018-09-05
Applicant: Chiesi Farmaceutici S.p.A.
Inventor： Alessandro Accetta , Anna Maria Capelli , Fabio Rancati , Gurdip Bhalay , Arnaud Jean Francois Auguste Cheguillaume , Christine Edwards , Patrizia Tisselli
IPC: C07D471/04 , A61K31/4995 , A61K31/496 , C07D487/08 , A61K9/00 , A61K31/437
Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are tyrosine analogues derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
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公开(公告)号：US09321776B2
公开(公告)日：2016-04-26
申请号：US14573887
申请日：2014-12-17
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Matteo Biagetti , Anna Maria Capelli , Alessandro Accetta , Laura Carzaniga
IPC: C07D487/04 , C07D473/38 , C07D471/04 , C07D495/04 , C07D413/14 , C07D519/00 , C07D473/34 , C07D405/12 , A61K31/52 , A61K45/06 , A61K31/506 , A61K31/519 , A61K31/53 , A61K31/5377 , C07D417/04 , C07D473/16
CPC classification number: C07D487/04 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D405/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D473/16 , C07D473/34 , C07D473/38 , C07D495/04 , C07D519/00 , Y02A50/409 , A61K2300/00
Abstract: Compounds of formula (I) described herein are useful for inhibiting phosphoinositide 3-kinases (PI3K) and the treatment of disorders associated with PI3K enzymes.
Abstract translation: 本文所述的式（I）化合物可用于抑制磷酸肌醇3-激酶（PI3K）和治疗与PI3K酶相关的病症。
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公开(公告)号：US20150166549A1
公开(公告)日：2015-06-18
申请号：US14573887
申请日：2014-12-17
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Matteo Biagetti , Anna Maria Capelli , Alessandro Accetta , Laura Carzaniga
IPC: C07D487/04 , C07D473/38 , C07D471/04 , C07D473/16 , C07D495/04 , C07D413/14 , C07D519/00 , C07D473/34 , C07D405/12
CPC classification number: C07D487/04 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D405/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D473/16 , C07D473/34 , C07D473/38 , C07D495/04 , C07D519/00 , Y02A50/409 , A61K2300/00
Abstract: Compounds of formula (I) described herein are useful for inhibiting phosphoinositide 3-kinases (PI3K) and the treatment of disorders associated with PI3K enzymes.
Abstract translation: 本文所述的式（I）化合物可用于抑制磷酸肌醇3-激酶（PI3K）和治疗与PI3K酶相关的病症。
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Patent Agency Ranking
公开(公告)号：US20180170939A1
公开(公告)日：2018-06-21
申请号：US15850720
申请日：2017-12-21
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Alessandro Accetta , Fabio Rancati , Anna Maria Capelli , David Edward Clark , Patrizia Tisselli , Christine Edwards , Gurdip Bhalay
IPC: C07D487/04 , A61K31/519 , A61K45/06 , A61K9/00 , A61P11/06
Abstract: Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and pulmonary arterial hypertension (PAH).
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公开(公告)号：US09527869B2
公开(公告)日：2016-12-27
申请号：US14741965
申请日：2015-06-17
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Matteo Biagetti , Alessandro Accetta , Anna Maria Capelli , Matilde Guala , Michele Retini
IPC: C07D487/04 , C07D471/04 , C07D473/02 , C07D519/00 , A61K31/519 , A61K31/5377 , A61K31/53 , A61K31/52 , A61K31/506 , A61K31/497 , A61P19/02 , A61P11/00 , A61P11/02
CPC classification number: C07D519/00 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/5377 , C07D471/04 , C07D473/02 , C07D487/04 , Y02A50/409
Abstract: Compounds of formula (I), defined herein, inhibit phosphoinositide 3-kinases (PI3K) and are useful for the treatment of disorders associated with PI3K enzymes.
Abstract translation: 本文定义的式（I）化合物抑制磷酸肌醇3-激酶（PI3K），可用于治疗与PI3K酶相关的疾病。
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公开(公告)号：US20160075710A1
公开(公告)日：2016-03-17
申请号：US14840420
申请日：2015-08-31
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Matteo BIAGETTI , Anna Maria Capelli , Matilde Guala
IPC: C07D487/04 , A61K31/5377 , A61K31/52 , A61K31/506 , C07D473/34 , A61K31/519 , C07D403/12
CPC classification number: C07D487/04 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/5377 , C07D403/12 , C07D473/34 , Y02A50/409
Abstract: Compounds of formula (I) described herein inhibit phosphoinositide 3-kinases (PI3K) and useful for the treatment of disorders associated with PI3K enzymes.
Abstract translation: 本文所述的式（I）化合物抑制磷酸肌醇3-激酶（PI3K）并且可用于治疗与PI3K酶相关的病症。
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公开(公告)号：US10954236B2
公开(公告)日：2021-03-23
申请号：US16656842
申请日：2019-10-18
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Alessandro Accetta , Fabio Rancati , Anna Maria Capelli , David Edward Clark , Patrizia Tisselli , Christine Edwards , Gurdip Bhalay , Arnaud Jean Francois Auguste Cheguillaume
IPC: A61P11/00 , C07D471/04 , C07D519/00 , C07D487/04 , A61K9/00 , A61K31/437 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/4725 , A61K31/496 , A61K31/498 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/5377 , A61K31/5383 , C07D471/08 , C07D498/04
Abstract: Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be used for the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
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公开(公告)号：US10584128B2
公开(公告)日：2020-03-10
申请号：US15850720
申请日：2017-12-21
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Alessandro Accetta , Fabio Rancati , Anna Maria Capelli , David Edward Clark , Patrizia Tisselli , Christine Edwards , Gurdip Bhalay
IPC: A61K31/519 , C07D487/04 , A61P11/06 , A61K9/00 , A61K45/06 , A61P11/00 , A61P37/00
Abstract: Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and pulmonary arterial hypertension (PAH).
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