公开(公告)号：US20180036368A1

公开(公告)日：2018-02-08

申请号：US15552405

申请日：2016-02-20

申请人： INSTITUT CURIE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUR (CNRS) ,  INSTITUT GUSTAVE ROUSSY ,  ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECERCE MEDICALE (INSERM) ,  UNIVERSITE de I'Ecole de Medecine

发明人： Eric DEUTSCH ,  Johannes LUDGER ,  Michele MONDINI ,  Mevyn NIZARD ,  Jean-Luc PERFETTINI ,  Eric TARTOUR ,  Thi TRAN

IPC分类号： A61K38/16 ,  A61K41/00 ,  A61N5/10 ,  A61K47/64

CPC分类号： A61K38/164 ,  A61K41/0038 ,  A61K47/6415 ,  A61K47/646 ,  A61N5/10 ,  A61N2005/1098

摘要： Disclosed is a composition for use in the prevention or treatment of a subject suffering from a cancer in combination with radiotherapy, wherein the composition includes a conjugate, eventually associated with pharmaceutically acceptable carrier, the conjugate including i) the Shiga Toxin B subunit (STxB), a fragment or a derivative thereof; and ii) at least one epitope associated with the cancer.