公开(公告)号：US20180036368A1

公开(公告)日：2018-02-08

申请号：US15552405

申请日：2016-02-20

申请人： INSTITUT CURIE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUR (CNRS) ,  INSTITUT GUSTAVE ROUSSY ,  ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECERCE MEDICALE (INSERM) ,  UNIVERSITE de I'Ecole de Medecine

发明人： Eric DEUTSCH ,  Johannes LUDGER ,  Michele MONDINI ,  Mevyn NIZARD ,  Jean-Luc PERFETTINI ,  Eric TARTOUR ,  Thi TRAN

IPC分类号： A61K38/16 ,  A61K41/00 ,  A61N5/10 ,  A61K47/64

CPC分类号： A61K38/164 ,  A61K41/0038 ,  A61K47/6415 ,  A61K47/646 ,  A61N5/10 ,  A61N2005/1098

摘要： Disclosed is a composition for use in the prevention or treatment of a subject suffering from a cancer in combination with radiotherapy, wherein the composition includes a conjugate, eventually associated with pharmaceutically acceptable carrier, the conjugate including i) the Shiga Toxin B subunit (STxB), a fragment or a derivative thereof; and ii) at least one epitope associated with the cancer.

公开(公告)号：US20190201480A1

公开(公告)日：2019-07-04

申请号：US16243654

申请日：2019-01-09

申请人： INSTITUT CURIE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSTITUT GUSTAVE ROUSSY ,  ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (INSERM) ,  UNIVERSITE RENE DESCARTES - PARIS V

发明人： Eric DEUTSCH ,  Johannes LUDGER ,  Michele MONDINI ,  Mevyn NIZARD ,  Jean-Luc PERFETTINI ,  Eric TARTOUR ,  Thi TRAN

IPC分类号： A61K38/16 ,  A61K47/64 ,  A61K41/00 ,  A61N5/10

CPC分类号： A61K38/164 ,  A61K41/0038 ,  A61K47/6415 ,  A61K47/646 ,  A61N5/10 ,  A61N2005/1098

摘要： Disclosed is a composition for use in the prevention or treatment of a subject suffering from a cancer in combination with radiotherapy, wherein the composition includes a conjugate, eventually associated with pharmaceutically acceptable carrier, the conjugate including i) the Shiga Toxin B subunit (STxB), a fragment or a derivative thereof; and ii) at least one epitope associated with the cancer.

公开(公告)号：US20150045536A1

公开(公告)日：2015-02-12

申请号：US14478687

申请日：2014-09-05

申请人： INSTITUT CURIE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS VI)

发明人： Ludger JOHANNES ,  Eric TARTOUR ,  Bruno GOUD ,  Wolf Herve FRIDMAN

IPC分类号： A61K39/385 ,  C07K14/25

CPC分类号： A61K39/385 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/6037 ,  A61K2039/627 ,  C07K14/25 ,  C07K2319/00

摘要： The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys, wherein: STxB is the Shiga Toxin B subunit or a functional equivalent thereof, Z is an amino-acid devoided of sulfydryl group, n being 0, 1 or a polypeptide, Cys is the amino-acid Cysteine, and the use thereof for MHC class I and MHC class II presentation of antigens.

摘要翻译： 本发明涉及一种通用多肽载体，用于直接或间接靶向分子至Gb3受体表达细胞，并具有下式STxB-Z（n）-Cys，其中：STxB是志贺毒素B亚基或其功能等同物，Z 是缺乏巯基的氨基酸，n为0,1或多肽，Cys为氨基酸半胱氨酸，以及其用于MHC I类和MHC II类抗原呈递的用途。

公开(公告)号：US20140205630A1

公开(公告)日：2014-07-24

申请号：US14174286

申请日：2014-02-06

申请人： UNIVERSITE RENE DESCARTES PARIS 5 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS ,  ASSISTANCE PUBLIQUE HOPITAUX DE PARIS ,  INSTITUT CURIE

发明人： Eric TARTOUR

IPC分类号： A61K39/39

CPC分类号： A61K39/39 ,  A61K39/12 ,  A61K39/385 ,  A61K2039/5256 ,  A61K2039/55511 ,  A61K2039/55544 ,  A61K2039/55555 ,  A61K2039/6037 ,  C07K14/005 ,  C07K14/25 ,  C07K2319/00 ,  C12N7/00 ,  C12N2710/20022 ,  C12N2710/20034 ,  C12N2710/24143

摘要： The present invention relates to a composition comprising a) a B subunit of Shiga toxin or a functional equivalent thereof which is able to bind the Gb3 receptor, complexed with an antigen and b) at least one ligand of CDl capable of stimulating NK T cells; and to a pharmaceutical composition and a medicament comprising said composition.

摘要翻译： 本发明涉及包含a）志贺毒素的B亚基或其功能等同物，其能够结合与抗原复合的Gb3受体，和b）至少一种能够刺激NK T细胞的CD1配体; 以及包含所述组合物的药物组合物和药物。

公开(公告)号：US20240033366A1

公开(公告)日：2024-02-01

申请号：US18255462

申请日：2021-12-02

申请人： INSTITUT CURIE ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  COMMISSARIAT À L’ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES (CEA) ,  UNIVERSITE PARIS CITE ,  APHP (ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS)

发明人： Ludger JOHANNES ,  Anne BILLET ,  Jonathan ULMER ,  Denis SERVENT ,  Gilles MOURIER ,  Pascal KESSLER ,  Eric TARTOUR

IPC分类号： A61K47/64 ,  A61K38/16

CPC分类号： A61K47/6415 ,  A61K38/164 ,  A61K2123/00

摘要： Modified monomers of a Shiga toxin B-subunit (STxB) protein including at least one of: an addition of a reactive unnatural amino acid residue at the C-terminal extremity, and/or a substitution with a reactive unnatural amino acid residue at an amino acid position among Asp 3, Lys 8, Glu 10, Tyr 11, Lys 23, Lys 27, Thr 49, Lys 53, His 58, Asn 59, and Arg 69, reference made to the numbering of STxB from Shigella dysenteriae. Also relates to STxB conjugates, and oligomers, in particular pentamers, of these modified STxB proteins and STxB conjugates; as well as to compositions including the same and their use in treatment, vaccination and diagnosis methods.

公开(公告)号：US20170042994A1

公开(公告)日：2017-02-16

申请号：US15223323

申请日：2016-07-29

申请人： INSTITUT CURIE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE ,  ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS ,  UNIVERSITE PARIS DESCARTES

发明人： Eric TARTOUR ,  Ludger JOHANNES

IPC分类号： A61K39/00

CPC分类号： A61K39/0011 ,  A61K39/385 ,  A61K39/39 ,  A61K39/3955 ,  A61K2039/55522 ,  A61K2039/55561 ,  A61K2039/6037 ,  A61K2039/6056

摘要： A composition that can be used as a vaccine containing means for targeting at least one antigen to dendritic cells and as adjuvants a granulocyte macrophage colony stimulating factor and a CpG oligodeoxynucleotide and/or a CpG-like oligodeoxynucleotide. This composition can used to treat cancers, infectious diseases caused by bacterial, viral, fungal, parasitic or protozoan infections, allergies and/or autoimmune diseases.

摘要翻译： 可用作含有用于将至少一种抗原靶向树突状细胞的装置和作为佐剂的粒细胞巨噬细胞集落刺激因子和CpG寡脱氧核苷酸和/或CpG样寡脱氧核苷酸的组合物。 该组合物可用于治疗由细菌，病毒，真菌，寄生虫或原生动物感染，过敏和/或自身免疫性疾病引起的癌症，感染性疾病。