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公开(公告)号：US20170312262A9
公开(公告)日：2017-11-02
申请号：US15155749
申请日：2016-05-16
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: A61K31/4545 , C07D417/14 , C07D417/04 , C07D409/06 , C07D405/14 , C07D401/14 , C07D401/12 , C07D471/04 , C07D487/04
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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公开(公告)号：US20160009718A1
公开(公告)日：2016-01-14
申请号：US14769471
申请日：2014-03-12
Applicant: CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Alexandre Côté , Les A. Dakin , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D487/04
CPC classification number: C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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公开(公告)号：US20150259351A1
公开(公告)日：2015-09-17
申请号：US14661797
申请日：2015-03-18
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew S. Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D487/04 , C07D409/06 , C07D401/14 , C07D405/14 , C07D401/12 , C07D471/04
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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公开(公告)号：US09085583B2
公开(公告)日：2015-07-21
申请号：US14377214
申请日：2013-02-11
Applicant: Constellation—Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew S. Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: A61K31/535 , C07D401/00 , C07D487/04 , C07D401/14 , C07D401/12 , C07D417/04 , C07D417/14
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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公开(公告)号：US20150011546A1
公开(公告)日：2015-01-08
申请号：US14377214
申请日：2013-02-11
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew S. Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D487/04 , C07D401/14 , C07D417/14 , C07D401/12
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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Patent Agency Ranking
公开(公告)号：USRE47428E1
公开(公告)日：2019-06-11
申请号：US15878663
申请日：2018-01-24
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Les A. Dakin , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D401/12 , C07D401/14 , C07D487/04 , C07D417/04 , C07D417/14 , C07D405/14 , C07D471/04 , C07D409/06 , A61K31/4545
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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公开(公告)号：US20190125737A1
公开(公告)日：2019-05-02
申请号：US15994005
申请日：2018-05-31
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: A61K31/4545 , C07D471/04 , C07D409/06 , C07D405/14 , C07D401/14 , C07D487/04 , C07D417/04 , C07D401/12 , C07D417/14
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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公开(公告)号：US10258603B2
公开(公告)日：2019-04-16
申请号：US15592012
申请日：2017-05-10
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , Steven F. Bellon , Daniel J. Burdick , Alexandre Cote , Terry Crawford , Les A. Dakin , Vickie Hsiao-Wei Tsui , Michael Charles Hewitt , Yves LeBlanc , Steven R. Magnuson , Christopher G. Nasveschuk , F. Anthony Romero , Yong Tang , Alexander M. Taylor , Shumei Wang
IPC: A61K31/40 , C07D471/04 , C07D519/00
Abstract: The present invention relates to compounds of formula (I): and to salts thereof, wherein R1, R2, Rc, and Rd have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.
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公开(公告)号：US10150767B2
公开(公告)日：2018-12-11
申请号：US15592017
申请日：2017-05-10
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , Steven F. Bellon , Daniel J. Burdick , Alexandre Cote , Terry Crawford , Les A. Dakin , Vickie Hsiao-Wei Tsui , Michael Charles Hewitt , Yves LeBlanc , Steven R. Magnuson , Christopher G. Nasveschuk , Anthony F. Romero , Yong Tang , Alexander M. Taylor , Shumei Wang
IPC: C07D471/04 , A61K31/437 , C07D519/00 , A61K31/4985 , A61K31/496 , A61K31/4545 , A61K45/06
Abstract: The present invention relates to compounds of formula (I): and to salts thereof, wherein R1, R2, and Q have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.
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公开(公告)号：US10016405B2
公开(公告)日：2018-07-10
申请号：US15257275
申请日：2016-09-06
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: A61K31/4545 , C07D401/14 , C07D401/12 , C07D417/04 , C07D487/04 , C07D417/14 , C07D405/14 , C07D409/06 , C07D471/04
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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