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公开(公告)号：US10183009B2
公开(公告)日：2019-01-22
申请号：US15592013
申请日：2017-05-10
发明人： Brian K. Albrecht , Steven F. Bellon , Daniel J. Burdick , Alexandre Cote , Terry Crawford , Les A. Dakin , Vickie Hsiao-Wei Tsui , Michael Charles Hewitt , Yves LeBlanc , Steven R. Magnuson , Christopher G. Nasveschuk , F. Anthony Romero , Yong Tang , Alexander M. Taylor , Shumei Wang
IPC分类号： A61K31/40 , C07D471/04
摘要： The present invention relates to compounds of formula (I): and to salts thereof, wherein R1, R2, and Q have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.
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公开(公告)号：US10155764B2
公开(公告)日：2018-12-18
申请号：US15449692
申请日：2017-03-03
发明人： Brian K. Albrecht , Alexandre Cote , Terry Crawford , Martin Duplessis , Andrew Charles Good , Yves LeBlanc , Steven Magnuson , Christopher G. Nasveschuk , Richard Pastor , Anthony F. Romero , Alexander M. Taylor
IPC分类号： C07D487/04 , C07D403/12 , C07D401/12 , C07D237/32 , C07D471/04 , A61K31/502 , A61K31/5025 , A61K31/5377 , A61K31/55 , C07D237/34 , C07D405/12
摘要： The present invention relates to methods for treating PCAF and GCN5 mediated disorders using a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein ring A, R1, R3, R4, R5, and each Re have any of the values defined in the specification. Also included are novel compounds of Formula (I) and salts thereof, as well as pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20170342067A1
公开(公告)日：2017-11-30
申请号：US15592017
申请日：2017-05-10
发明人： Brian K. Albrecht , Steven F. Bellon , Daniel J. Burdick , Alexandre Cote , Terry Crawford , Les A. Dakin , Vickie Hsiao-Wei Tsui , Michael Charles Hewitt , Yves LeBlanc , Steven R. Magnuson , Christopher G. Nasveschuk , Anthony F. Romero , Yong Tang , Alexander M. Taylor , Shumei Wang
IPC分类号： C07D471/04 , A61K45/06 , A61K31/4985 , A61K31/496 , A61K31/4545 , C07D519/00 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4545 , A61K31/496 , A61K31/4985 , A61K45/06 , C07D519/00
摘要： The present invention relates to compounds of formula (I): and to salts thereof, wherein R1, R2, and Q have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.
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公开(公告)号：US20170340605A1
公开(公告)日：2017-11-30
申请号：US15592013
申请日：2017-05-10
发明人： Brian K. Albrecht , Steven F. Bellon , Daniel J. Burdick , Alexandre Cote , Terry Crawford , Les A. Dakin , Vickie Hsiao-Wei Tsui , Michael Charles Hewitt , Yves LeBlanc , Steven R. Magnuson , Christopher G. Nasveschuk , Anthony F. Romero , Yong Tang , Alexander M. Taylor , Shumei Wang
IPC分类号： A61K31/40 , C07D471/04
CPC分类号： A61K31/40 , C07D471/04
摘要： The present invention relates to compounds of formula (I): and to salts thereof, wherein R1, R2, and Q have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.
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公开(公告)号：US20170334883A1
公开(公告)日：2017-11-23
申请号：US15449706
申请日：2017-03-03
发明人： Brian K. Albrecht , Alexandre Cote , Terry Crawford , Martin Duplessis , Andrew Charles Good , Yves LeBlanc , Steven Magnuson , Christopher G. Nasveschuk , Richard Pastor , Anthony F. Romero , Alexander M. Taylor
IPC分类号： C07D403/12 , C07D401/12 , C07D401/04 , C07D253/075 , A61K45/06 , C07D403/04 , A61K31/53
CPC分类号： C07D403/12 , A61K31/53 , A61K45/06 , A61P35/00 , C07D249/12 , C07D253/075 , C07D401/04 , C07D401/12 , C07D403/04
摘要： The present invention relates to methods for treating PCAF mediated disorders using a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1, R3-R6, X, and each Re have any of the values defined in the specification. Also included are novel compounds of formula (I) and salts thereof, as well as pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.
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![BENZO [C] ISOXAZOLOAZEPINE BROMODOMAIN INHIBITORS AND USES THEREOF](/abs-image/US/2017/03/23/US20170079984A1/abs.jpg.150x150.jpg)
公开(公告)号：US20170079984A1
公开(公告)日：2017-03-23
申请号：US15277854
申请日：2016-09-27
IPC分类号： A61K31/55
CPC分类号： A61K31/55 , C07D498/04
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US09469646B2
公开(公告)日：2016-10-18
申请号：US14839273
申请日：2015-08-28
发明人： Brian K. Albrecht , James Edmund Audia , Les A. Dakin , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC分类号： C07D401/12 , C07D401/14 , C07D487/04 , C07D417/04 , C07D417/14 , C07D405/14 , C07D409/06 , C07D471/04
CPC分类号： A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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8.发明申请公开(公告)号：US20150376190A1
公开(公告)日：2015-12-31
申请号：US14766632
申请日：2014-02-11
发明人： Brian K. Albrecht , James Edmund Audia , Andrew S. Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Agents having the structural Formula (II) for modulating histone methyl modifying enzymes, compositions and uses thereof for instance as anti-cancer agents are provided herein.
摘要翻译： 具有用于调节组蛋白甲基修饰酶的结构式（II）的试剂，其组合物和用途，例如作为抗癌剂。
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公开(公告)号：US20140275092A1
公开(公告)日：2014-09-18
申请号：US14209449
申请日：2014-03-13
IPC分类号： C07D487/04 , C07D498/04
CPC分类号： C07D487/04 , A61K31/337 , A61K31/437 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D487/14 , C07D498/04 , C12N9/99
摘要： The present invention relates to compounds useful as inhibitors of one or more histone demethylses. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作一种或多种组蛋白脱甲基酶抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
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公开(公告)号：US10526287B2
公开(公告)日：2020-01-07
申请号：US15567978
申请日：2016-04-22
发明人： Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Rishi G. Vaswani
IPC分类号： C07D211/22 , C07D211/26 , C07D309/20 , C07D215/44 , C07D317/28 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/04 , C07D239/30 , C07C215/44 , C07D417/06 , C07D263/32 , C07D205/12 , C07D207/32 , C07D211/36 , C07D213/64 , C07D305/06 , C07C255/58 , C07C211/09 , C07C211/36 , C07C211/40 , C07C215/14 , C07C217/08 , C07C229/10 , C07C229/38 , C07C229/46 , C07C233/41 , C07C237/06 , C07C255/24 , C07C215/42 , C07C255/30 , C07D211/58 , C07D211/76 , C07D213/38 , C07D213/69 , C07D213/73 , C07D295/195 , A61P35/00
摘要： Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.
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