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公开(公告)号：US20100143368A1
公开(公告)日：2010-06-10
申请号：US12517183
申请日：2007-11-30
申请人： David John King , Alison Witte , Heidi N. LeBlanc , Richard Theolis , Asna Masood , Mark Yamanaka , Kyra D. Emory , Sarah R. Reed , Tim Sproul , Chetana Rao-Naik , David Passmore
发明人： David John King , Alison Witte , Heidi N. LeBlanc , Richard Theolis , Asna Masood , Mark Yamanaka , Kyra D. Emory , Sarah R. Reed , Tim Sproul , Chetana Rao-Naik , David Passmore
CPC分类号： C07K16/2803 , A61K39/39558 , A61K45/06 , A61K47/6829 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/3061 , C07K2317/21 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/70 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to CD22 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CD22, as well as methods for treating various cancers and inflammatory and autoimmune disorders using an anti-CD22 antibody of this disclosure.
摘要翻译： 本公开提供了以高亲和力特别是人单克隆抗体特异性结合CD22的分离的单克隆抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了抗体 - 配偶体分子缀合物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了用于检测CD22的方法，以及使用本公开的抗CD22抗体治疗各种癌症和炎性和自身免疫性疾病的方法。
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公开(公告)号：US08268970B2
公开(公告)日：2012-09-18
申请号：US12681215
申请日：2008-09-29
申请人： Jonathan A. Terrett , Sarah L. Pogue , Kristopher Toy , Lan Yang , Chetana Rao-Naik , Bingliang Chen
发明人： Jonathan A. Terrett , Sarah L. Pogue , Kristopher Toy , Lan Yang , Chetana Rao-Naik , Bingliang Chen
CPC分类号： C07K16/30 , A61K39/39558 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/80 , C07K2317/92 , A61K2300/00
摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human mesothelin. In certain embodiments, the antibodies are capable of internalizing into mesothelin-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. The invention further provides anti-mesothelin antibodies that can inhibit the binding of mesothelin to the ovarian cancer antigen CA125. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting mesothelin, as well as methods for treating cancers, such as mesotheliomas, pancreatic cancers and ovarian cancers, using an anti-mesothelin antibody of this disclosure.
摘要翻译： 本公开提供以高亲和力特别是人单克隆抗体特异性结合间皮素的分离的单克隆抗体。 优选地，所述抗体结合人间皮素。 在某些实施方案中，抗体能够内化成表达间皮素的细胞或能够介导抗原依赖性细胞毒性。 本发明还提供可以抑制间皮素与卵巢癌抗原CA125的结合的抗间皮素抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了抗体 - 配偶体分子缀合物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了用于检测间皮素的方法，以及使用本公开的抗间皮素抗体治疗癌症的方法，例如间皮瘤，胰腺癌和卵巢癌。
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公开(公告)号：US20130028906A1
公开(公告)日：2013-01-31
申请号：US13587644
申请日：2012-08-16
申请人： Jonathan A. Terrett , Sarah L. Pogue , Kristopher Toy , Lan Yang , Chetana Rao-Naik , Bingliang Chen
发明人： Jonathan A. Terrett , Sarah L. Pogue , Kristopher Toy , Lan Yang , Chetana Rao-Naik , Bingliang Chen
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/30 , A61K39/39558 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/80 , C07K2317/92 , A61K2300/00
摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human mesothelin. In certain embodiments, the antibodies are capable of internalizing into mesothelin-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. The invention further provides anti-mesothelin antibodies that can inhibit the binding of mesothelin to the ovarian cancer antigen CA125. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting mesothelin, as well as methods for treating cancers, such as mesotheliomas, pancreatic cancers and ovarian cancers, using an anti-mesothelin antibody of this disclosure.
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公开(公告)号：US08399623B2
公开(公告)日：2013-03-19
申请号：US13587500
申请日：2012-08-16
申请人： Jonathan A. Terrett , Sarah L. Pogue , Kristopher Toy , Lan Yang , Chetana Rao-Naik , Bingliang Chen
发明人： Jonathan A. Terrett , Sarah L. Pogue , Kristopher Toy , Lan Yang , Chetana Rao-Naik , Bingliang Chen
CPC分类号： C07K16/30 , A61K39/39558 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/80 , C07K2317/92 , A61K2300/00
摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human mesothelin. In certain embodiments, the antibodies are capable of internalizing into mesothelin-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. The invention further provides anti-mesothelin antibodies that can inhibit the binding of mesothelin to the ovarian cancer antigen CA125. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting mesothelin, as well as methods for treating cancers, such as mesotheliomas, pancreatic cancers and ovarian cancers, using an anti-mesothelin antibody of this disclosure.
摘要翻译： 本公开提供以高亲和力特别是人单克隆抗体特异性结合间皮素的分离的单克隆抗体。 优选地，所述抗体结合人间皮素。 在某些实施方案中，抗体能够内化成表达间皮素的细胞或能够介导抗原依赖性细胞毒性。 本发明还提供可以抑制间皮素与卵巢癌抗原CA125的结合的抗间皮素抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了抗体 - 配偶体分子缀合物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了使用本公开的抗间皮素抗体检测间皮素的方法以及用于治疗癌症的方法，诸如间皮瘤，胰腺癌和卵巢癌。
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公开(公告)号：US08383779B2
公开(公告)日：2013-02-26
申请号：US13587572
申请日：2012-08-16
申请人： Jonathan A. Terrett , Sarah L. Pogue , Kristopher Toy , Lan Yang , Chetana Rao-Naik , Bingliang Chen
发明人： Jonathan A. Terrett , Sarah L. Pogue , Kristopher Toy , Lan Yang , Chetana Rao-Naik , Bingliang Chen
CPC分类号： C07K16/30 , A61K39/39558 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/80 , C07K2317/92 , A61K2300/00
摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human mesothelin. In certain embodiments, the antibodies are capable of internalizing into mesothelin-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. The invention further provides anti-mesothelin antibodies that can inhibit the binding of mesothelin to the ovarian cancer antigen CA125. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting mesothelin, as well as methods for treating cancers, such as mesotheliomas, pancreatic cancers and ovarian cancers, using an anti-mesothelin antibody of this disclosure.
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公开(公告)号：US20130028905A1
公开(公告)日：2013-01-31
申请号：US13587572
申请日：2012-08-16
申请人： Jonathan A. Terrett , Sarah L. Pogue , Kristopher Toy , Lan Yang , Chetana Rao-Naik , Bingliang Chen
发明人： Jonathan A. Terrett , Sarah L. Pogue , Kristopher Toy , Lan Yang , Chetana Rao-Naik , Bingliang Chen
IPC分类号： C07K16/30 , A61P35/00 , A61K39/395
CPC分类号： C07K16/30 , A61K39/39558 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/80 , C07K2317/92 , A61K2300/00
摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human mesothelin. In certain embodiments, the antibodies are capable of internalizing into mesothelin-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. The invention further provides anti-mesothelin antibodies that can inhibit the binding of mesothelin to the ovarian cancer antigen CA125. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting mesothelin, as well as methods for treating cancers, such as mesotheliomas, pancreatic cancers and ovarian cancers, using an anti-mesothelin antibody of this disclosure.
摘要翻译： 本公开提供以高亲和力特别是人单克隆抗体特异性结合间皮素的分离的单克隆抗体。 优选地，所述抗体结合人间皮素。 在某些实施方案中，抗体能够内化成表达间皮素的细胞或能够介导抗原依赖性细胞毒性。 本发明还提供可以抑制间皮素与卵巢癌抗原CA125的结合的抗间皮素抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了抗体 - 配偶体分子缀合物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了使用本公开的抗间皮素抗体检测间皮素的方法以及用于治疗癌症的方法，诸如间皮瘤，胰腺癌和卵巢癌。
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公开(公告)号：US08425904B2
公开(公告)日：2013-04-23
申请号：US13587644
申请日：2012-08-16
申请人： Jonathan A. Terrett , Sarah L. Pogue , Kristopher Toy , Lan Yang , Chetana Rao-Naik , Bingliang Chen
发明人： Jonathan A. Terrett , Sarah L. Pogue , Kristopher Toy , Lan Yang , Chetana Rao-Naik , Bingliang Chen
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K16/30 , A61K39/39558 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/80 , C07K2317/92 , A61K2300/00
摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human mesothelin. In certain embodiments, the antibodies are capable of internalizing into mesothelin-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. The invention further provides anti-mesothelin antibodies that can inhibit the binding of mesothelin to the ovarian cancer antigen CA125. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting mesothelin, as well as methods for treating cancers, such as mesotheliomas, pancreatic cancers and ovarian cancers, using an anti-mesothelin antibody of this disclosure.
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公开(公告)号：US20130028904A1
公开(公告)日：2013-01-31
申请号：US13587500
申请日：2012-08-16
申请人： Jonathan A. Terrett , Sarah L. Pogue , Kristopher Toy , Lan Yang , Chetana Rao-Naik , Bingliang Chen
发明人： Jonathan A. Terrett , Sarah L. Pogue , Kristopher Toy , Lan Yang , Chetana Rao-Naik , Bingliang Chen
IPC分类号： C07K16/30 , A61P35/00 , A61K39/395
CPC分类号： C07K16/30 , A61K39/39558 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/80 , C07K2317/92 , A61K2300/00
摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human mesothelin. In certain embodiments, the antibodies are capable of internalizing into mesothelin-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. The invention further provides anti-mesothelin antibodies that can inhibit the binding of mesothelin to the ovarian cancer antigen CA125. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting mesothelin, as well as methods for treating cancers, such as mesotheliomas, pancreatic cancers and ovarian cancers, using an anti-mesothelin antibody of this disclosure.
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公开(公告)号：US20110262448A1
公开(公告)日：2011-10-27
申请号：US12681215
申请日：2008-09-29
申请人： Jonathan A. TERRETT , Sarah L. Pogue , Kristopher Toy , Lan Yang , Chetana Rao-Naik , Bingliang Chen
发明人： Jonathan A. TERRETT , Sarah L. Pogue , Kristopher Toy , Lan Yang , Chetana Rao-Naik , Bingliang Chen
IPC分类号： A61K39/395 , A61P35/00 , A61K39/44 , C07K16/18
CPC分类号： C07K16/30 , A61K39/39558 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/80 , C07K2317/92 , A61K2300/00
摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human mesothelin. In certain embodiments, the antibodies are capable of internalizing into mesothelin-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. The invention further provides anti-mesothelin antibodies that can inhibit the binding of mesothelin to the ovarian cancer antigen CA125. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting mesothelin, as well as methods for treating cancers, such as mesotheliomas, pancreatic cancers and ovarian cancers, using an anti-mesothelin antibody of this disclosure.
摘要翻译： 本公开提供以高亲和力特别是人单克隆抗体特异性结合间皮素的分离的单克隆抗体。 优选地，所述抗体结合人间皮素。 在某些实施方案中，抗体能够内化成表达间皮素的细胞或能够介导抗原依赖性细胞毒性。 本发明还提供可以抑制间皮素与卵巢癌抗原CA125的结合的抗间皮素抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了抗体 - 配偶体分子缀合物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了使用本公开的抗间皮素抗体检测间皮素的方法以及用于治疗癌症的方法，诸如间皮瘤，胰腺癌和卵巢癌。
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