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公开(公告)号：US08524777B2
公开(公告)日：2013-09-03
申请号：US13551379
申请日：2012-07-17
IPC分类号： A61K31/14 , A61K31/557 , A61K31/5575
CPC分类号： A61K31/5575 , A61K9/0048 , A61K9/08 , A61K31/14 , A61K31/164 , A61K31/165 , A61K47/02 , A61K47/183 , A61K47/186 , A61K2300/00
摘要： A composition comprising from 0.005% to 0.02% bimatoprost by weight and from 100 ppm to 250 ppm benzalkonium chloride, wherein said composition is an aqueous liquid which is formulated for ophthalmic administration is disclosed herein. A method which is useful in treating glaucoma or ocular hypertension related thereto is also disclosed herein.
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公开(公告)号：US08338479B2
公开(公告)日：2012-12-25
申请号：US12351383
申请日：2009-01-09
IPC分类号： A61K31/19 , A61K31/215
CPC分类号： A61K31/5575 , A01N33/12 , A61K9/0048 , A61K31/14 , A61K31/165 , A61K31/557 , A61K47/02 , A61K47/12
摘要： A composition comprising from 0.005% to 0.02% bimatoprost by weight and from 100 ppm to 250 ppm benzalkonium chloride, wherein said composition is an aqueous liquid which is formulated for ophthalmic administration is disclosed herein.A method which is useful in treating glaucoma or ocular hypertension related thereto is also disclosed herein.
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公开(公告)号：US08299118B2
公开(公告)日：2012-10-30
申请号：US13370529
申请日：2012-02-10
IPC分类号： A61K31/19 , A61K31/215
CPC分类号： A61K31/5575 , A01N33/12 , A61K9/0048 , A61K31/14 , A61K31/165 , A61K31/557 , A61K47/02 , A61K47/12
摘要： A composition comprising from 0.005% to 0.02% bimatoprost by weight and from 100 ppm to 250 ppm benzalkonium chloride, wherein said composition is an aqueous liquid which is formulated for ophthalmic administration is disclosed herein. A method which is useful in treating glaucoma or ocular hypertension related thereto is also disclosed herein.
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公开(公告)号：US07851504B2
公开(公告)日：2010-12-14
申请号：US11083261
申请日：2005-03-16
IPC分类号： A61K31/19 , A61K31/215
CPC分类号： A61K31/5575 , A01N33/12 , A61K9/0048 , A61K31/14 , A61K31/165 , A61K31/557 , A61K47/02 , A61K47/12
摘要： A composition comprising from 0.005% to 0.02% bimatoprost by weight and from 100 ppm to 250 ppm benzalkonium chloride, wherein said composition is an aqueous liquid which is formulated for ophthalmic administration is disclosed herein.A method which is useful in treating glaucoma or ocular hypertension related thereto is also disclosed herein.
摘要翻译： 本文公开了包含0.005％至0.02％的比马前列素和100ppm至250ppm苯扎氯铵的组合物，其中所述组合物是配制用于眼部给药的水性液体。 本文还公开了可用于治疗与其有关的青光眼或高眼压症的方法。
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公开(公告)号：US20130079414A1
公开(公告)日：2013-03-28
申请号：US13254543
申请日：2010-03-04
IPC分类号： A61K31/165
CPC分类号： A61K31/5575 , A61K9/0048 , A61K9/08 , A61K31/14 , A61K31/164 , A61K31/165 , A61K47/02 , A61K47/183 , A61K47/186 , A61K2300/00
摘要： A composition comprising from 0.005% to 0.02% bimatoprost by weight and from 100 ppm to 250 ppm benzalkonium chloride, wherein said composition is an aqueous liquid which is formulated for ophthalmic administration is disclosed herein. A method which is useful in treating glaucoma or ocular hypertension related thereto is also disclosed herein.
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公开(公告)号：US20060258617A1
公开(公告)日：2006-11-16
申请号：US11460392
申请日：2006-07-27
申请人： Robert Lyon , Chin-Ming Chang , Joan-En Chang-Lin , James Chang , Orest Olejnik
发明人： Robert Lyon , Chin-Ming Chang , Joan-En Chang-Lin , James Chang , Orest Olejnik
IPC分类号： A61K31/724 , A61K31/717 , A61K31/573
CPC分类号： A61K9/0014 , A61K9/0048 , A61K31/57 , A61K31/573 , A61K31/724 , A61K47/38 , A61K47/40
摘要： Disclosed herein are methods of delivering drugs or therapeutically active agents to the back of the eye via topical administration of compositions comprising cyclodextrin derivatives. Compositions related thereto are also disclosed herein.
摘要翻译： 本文公开了通过局部施用包含环糊精衍生物的组合物将药物或治疗活性剂递送至眼睛后部的方法。 本文还公开了与其相关的组合物。
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公开(公告)号：US20050234018A1
公开(公告)日：2005-10-20
申请号：US10826843
申请日：2004-04-15
申请人： Robert Lyons , Chin-Ming Chang , Joan-En Chang-Lin , James Chang , Orest Olejnik
发明人： Robert Lyons , Chin-Ming Chang , Joan-En Chang-Lin , James Chang , Orest Olejnik
IPC分类号： A61K9/00 , A61K31/00 , A61K31/57 , A61K31/573 , A61K31/724 , A61K47/38 , A61K47/40
CPC分类号： A61K9/0014 , A61K9/0048 , A61K31/57 , A61K31/573 , A61K31/724 , A61K47/38 , A61K47/40
摘要： Disclosed herein are methods of delivering drugs or therapeutically active agents to the back of the eye via topical administration of compositions comprising cyclodextrin derivatives. Compositions related thereto are also disclosed herein.
摘要翻译： 本文公开了通过局部施用包含环糊精衍生物的组合物将药物或治疗活性剂递送至眼睛后部的方法。 本文还公开了与其相关的组合物。
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公开(公告)号：US20060211770A1
公开(公告)日：2006-09-21
申请号：US11083261
申请日：2005-03-16
申请人： Chin-Ming Chang , James Chang , Rhett Schiffman , R. Jordan , Joan-En Chang-Lin
发明人： Chin-Ming Chang , James Chang , Rhett Schiffman , R. Jordan , Joan-En Chang-Lin
IPC分类号： A61K31/557 , A61K31/14
CPC分类号： A61K31/5575 , A01N33/12 , A61K9/0048 , A61K31/14 , A61K31/165 , A61K31/557 , A61K47/02 , A61K47/12
摘要： A composition comprising from 0.005% to 0.02% bimatoprost by weight and from 100 ppm to 250 ppm benzalkonium chloride, wherein said composition is an aqueous liquid which is formulated for ophthalmic administration is disclosed herein. A method which is useful in treating glaucoma or ocular hypertension related thereto is also disclosed herein.
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19.发明申请KETOROLAC TROMETHAMINE COMPOSITIONS FOR TREATING OR PREVENTING OCULAR PAIN 审中-公开用于治疗或预防眼痛的KETOROLAC TROMETHAMINE组合物公开(公告)号：US20130030032A1
公开(公告)日：2013-01-31
申请号：US13393739
申请日：2010-08-31
申请人： Eldon Q. Farnes , Mayssa Attar , Rhett M. Schiffman , Chin-Ming Chang , Richard S. Graham , Devin F. Welty
发明人： Eldon Q. Farnes , Mayssa Attar , Rhett M. Schiffman , Chin-Ming Chang , Richard S. Graham , Devin F. Welty
IPC分类号： A61K31/407 , A61P29/00 , A61P27/02
CPC分类号： A61K31/407 , A61K9/0048 , A61K9/08 , A61K31/14 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/186 , A61K47/38
摘要： The present invention provides an aqueous ophthalmic solution comprising an effective amount of ketorolac which comprises carboxymethyl cellulose in an aqueous solution which provides increased visual acuity in users and wherein said concentration of carboxymethyl cellulose is selected to provide an increased absorption of ketorolac in the eye of a patient which is at least 130% greater than the absorption of a comparative aqueous ketorolac ophthalmic solution having the same concentration of ketorolac.
摘要翻译： 本发明提供一种眼用水溶液，其包含有效量的酮咯酸，其在水溶液中包含羧甲基纤维素，其在使用者中提供增加的视力，并且其中选择所述羧甲基纤维素的浓度以提高酮咯酸在眼睛中的吸收 患者比具有相同浓度的酮咯酸的对比的水性酮咯酸眼科溶液的吸收大至少130％。
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公开(公告)号：US20110160271A1
公开(公告)日：2011-06-30
申请号：US12953622
申请日：2010-11-24
申请人： Eldon Q. Farnes , Mayssa Attar , Rhett M. Schiffman , Chin-Ming Chang , Richard S. Graham , Devin F. Welty
发明人： Eldon Q. Farnes , Mayssa Attar , Rhett M. Schiffman , Chin-Ming Chang , Richard S. Graham , Devin F. Welty
IPC分类号： A61K31/407 , A61P29/00 , A61P27/02
CPC分类号： A61K31/14 , A61K9/0048 , A61K31/407 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/186 , A61K47/38
摘要： The present invention provides an aqueous ophthalmic solution comprising an effective amount of ketorolac which comprises carboxymethyl cellulose in an aqueous solution wherein said concentration of carboxymethyl cellulose is selected to provide an increased absorption of ketorolac in the eye of a patient that is at least 130% greater than the absorption of a comparative aqueous ketorolac ophthalmic solution having the same concentration of ketorolac.
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