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公开(公告)号：US5622955A
公开(公告)日：1997-04-22
申请号：US456164
申请日：1995-05-31
申请人： David W. Boykin , Christine C. Dykstra , Richard R. Tidwell , James E. Hall , W. David Wilson , Arvind Kumar , Byron L. Blagburn
发明人： David W. Boykin , Christine C. Dykstra , Richard R. Tidwell , James E. Hall , W. David Wilson , Arvind Kumar , Byron L. Blagburn
IPC分类号： G01N33/50 , A61K31/505 , A61K31/506 , C07D239/26 , C07D307/52 , C07D307/54 , C07D307/58 , C07D403/10 , C07D403/14 , C07D405/14 , C09B23/01 , C12Q1/68 , G01N21/78 , G01N33/52 , G01N33/58
CPC分类号： C07D239/26 , A61K31/505 , A61K31/506 , C07D307/54 , C07D403/10 , C07D403/14 , C07D405/14 , C09B23/0075 , G01N33/52
摘要： The present invention provides methods for treating Cryptosporidium parvum in a subject in need of such treatment. The methods comprises administering to the subject a compound of Formula I: ##STR1##
摘要翻译： 本发明提供了在需要这种治疗的受试者中治疗隐孢子虫的方法。 所述方法包括向受试者施用式I化合物：（I）
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12.发明授权Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans 失效使用双阳离子芳基呋喃荧光检测核酸和细胞骨架元件的方法
公开(公告)号：US5594138A
公开(公告)日：1997-01-14
申请号：US453232
申请日：1995-05-30
申请人： Christine C. Dykstra , Richard R. Tidwell , David W. Boykin , W. David Wilson , Jaroslaw Spychala , Bijan P. Das , Arvind Kumar
发明人： Christine C. Dykstra , Richard R. Tidwell , David W. Boykin , W. David Wilson , Jaroslaw Spychala , Bijan P. Das , Arvind Kumar
IPC分类号： G01N33/50 , A61K31/505 , A61K31/506 , C07D307/52 , C07D307/54 , C07D307/58 , C07D403/10 , C07D403/14 , C07D405/14 , C09B23/01 , C12Q1/68 , G01N21/78 , G01N33/52 , G01N33/58 , C07D405/00
CPC分类号： G01N33/52 , A61K31/505 , A61K31/506 , C07D307/54 , C07D403/10 , C07D403/14 , C07D405/14 , C09B23/0075 , Y10S435/808 , Y10S435/81
摘要： Disclosed is a method of fluorescent detection of a nucleic acid. The method comprises contacting to the nucleic acid a bis-dicationic aryl furan compound, such as 2,5-bis[4-(4,5,6,7-tetrahydro-1H-1,3-diazepin-2-yl) phenyl] furan; 2,5-bis{[4-(N-isopropyl) amidino] phenyl}furan; and physiologically acceptable salts thereof, and exposing the nucleic acid to light at a frequency to induce fluorescence of the compound. A method for fluorescent detection of cytoskeleton elements, and novel bis-dicationic aryl furan compounds are also disclosed.
摘要翻译： 公开了一种荧光检测核酸的方法。 该方法包括使双酸性芳基呋喃化合物如2,5-双[4-（4,5,6,7-四氢-1H-1,3-二氮杂-2-基）苯基 ]呋喃 2,5-双{[4-（N-异丙基）脒基]苯基}呋喃; 和其生理上可接受的盐，并且以一定的频率使核酸暴露以诱导化合物的荧光。 还公开了细胞骨架元件的荧光检测方法，以及新型的双 - 二盐酸芳基呋喃化合物。
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13.发明授权
公开(公告)号：US5817687A
公开(公告)日：1998-10-06
申请号：US865425
申请日：1997-05-29
IPC分类号： C07D401/14 , A61K31/415 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/445 , A61K31/497 , A61K31/505 , A61K31/506 , A61P31/04 , C07D403/14 , C07D405/14
CPC分类号： A61K31/427 , A61K31/4184 , A61K31/422 , A61K31/4439 , A61K31/497 , A61K31/506
摘要： The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.
摘要翻译： 本发明提供了在需要这种治疗的受试者中治疗新型隐球菌和白色念珠菌的方法。 所述方法包括以有效治疗病症的量给予受试者双阳离子双苯并咪唑。
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公开(公告)号：US5792782A
公开(公告)日：1998-08-11
申请号：US865424
申请日：1997-05-29
IPC分类号： C07D401/14 , A61K31/415 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/445 , A61K31/497 , A61K31/505 , A61K31/506 , A61P31/04 , C07D403/14 , C07D405/14
CPC分类号： A61K31/427 , A61K31/4184 , A61K31/422 , A61K31/4439 , A61K31/497 , A61K31/506
摘要： The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.
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15.发明授权Methods of combatting infectious diseases using dicationic bis-benzimidazoles 有权使用双极化双苯并咪唑来防治传染病的方法
公开(公告)号：US6046226A
公开(公告)日：2000-04-04
申请号：US352391
申请日：1999-07-13
IPC分类号： C07D401/14 , A61K31/415 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/445 , A61K31/497 , A61K31/505 , A61K31/506 , A61P31/04 , C07D403/14 , C07D405/14
CPC分类号： A61K31/427 , A61K31/4184 , A61K31/422 , A61K31/4439 , A61K31/497 , A61K31/506
摘要： The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.
摘要翻译： 本发明提供了在需要这种治疗的受试者中治疗新型隐球菌和白色念珠菌的方法。 所述方法包括以有效治疗病症的量给予受试者双阳离子双苯并咪唑。
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16.发明授权Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans, and kits useful therefor 失效使用双阳离子芳基呋喃荧光检测核酸和细胞骨架元件的方法，以及可用于其的试剂盒
公开(公告)号：US5723288A
公开(公告)日：1998-03-03
申请号：US238766
申请日：1994-05-06
申请人： Christine C. Dykstra , Richard R. Tidwell , David W. Boykin , W. David Wilson , Jaroslaw Spychala , Bijan P. Das , Arvind Kumar
发明人： Christine C. Dykstra , Richard R. Tidwell , David W. Boykin , W. David Wilson , Jaroslaw Spychala , Bijan P. Das , Arvind Kumar
IPC分类号： G01N33/50 , A61K31/505 , A61K31/506 , C07D307/52 , C07D307/54 , C07D307/58 , C07D403/10 , C07D403/14 , C07D405/14 , C09B23/01 , C12Q1/68 , G01N21/78 , G01N33/52 , G01N33/58
CPC分类号： G01N33/52 , A61K31/505 , A61K31/506 , C07D307/54 , C07D403/10 , C07D403/14 , C07D405/14 , C09B23/0075 , Y10S435/808 , Y10S435/81
摘要： Disclosed is a method of fluorescent detection of a nucleic acid. The method comprises contacting to the nucleic acid a bis-dicationic aryl furan compound, such as 2,5-bis�4-(4,5,6,7-tetrahydro-1H-1,3-diazepin-2-yl) phenyl! furan; 2,5-bis{�4-(N-isopropyl) amidino! phenyl}furan; and physiologically acceptable salts thereof, and exposing the nucleic acid to light at a frequency to induce fluorescence of the compound. A method for fluorescent detection of cytoskeleton elements, and novel bis-dicationic aryl furan compounds are also disclosed.
摘要翻译： 公开了一种荧光检测核酸的方法。 该方法包括使双酸性芳基呋喃化合物如2,5-双[4-（4,5,6,7-四氢-1H-1,3-二氮杂-2-基）苯基 ]呋喃 2,5-双{[4-（N-异丙基）脒基]苯基}呋喃; 和其生理上可接受的盐，并且以一定的频率使核酸暴露以诱导化合物的荧光。 还公开了细胞骨架元件的荧光检测方法，以及新型的双 - 二盐酸芳基呋喃化合物。
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公开(公告)号：US5686456A
公开(公告)日：1997-11-11
申请号：US564879
申请日：1995-11-28
申请人： David W. Boykin , Christine C. Dykstra , Richard R. Tidwell , James E. Hall , W. David Wilson , Arvind Kumar
发明人： David W. Boykin , Christine C. Dykstra , Richard R. Tidwell , James E. Hall , W. David Wilson , Arvind Kumar
IPC分类号： G01N33/50 , A61K31/505 , A61K31/506 , C07D239/26 , C07D307/52 , C07D307/54 , C07D307/58 , C07D403/10 , C07D403/14 , C07D405/14 , C09B23/01 , C12Q1/68 , G01N21/78 , G01N33/52 , G01N33/58
CPC分类号： C07D239/26 , A61K31/505 , A61K31/506 , C07D307/54 , C07D403/10 , C07D403/14 , C07D405/14 , C09B23/0075 , G01N33/52
摘要： The present invention provides methods for treating Pneumocystis carinii pneumonia in a subject in need of such treatment. The methods comprise administering to a subject in need thereof, a pyrimidine of Formula I. ##STR1## wherein the variables are as defined in the specification.
摘要翻译： 本发明提供了在需要这种治疗的个体中治疗卡氏肺囊虫肺炎的方法。 所述方法包括向有需要的受试者施用式I的嘧啶。其中变量如说明书中所定义。
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18.发明授权Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans 失效使用双阳离子芳基呋喃荧光检测核酸和细胞骨架元件的方法
公开(公告)号：US5667975A
公开(公告)日：1997-09-16
申请号：US485381
申请日：1995-06-07
IPC分类号： G01N33/50 , A61K31/505 , A61K31/506 , C07D307/52 , C07D307/54 , C07D307/58 , C07D403/10 , C07D403/14 , C07D405/14 , C09B23/01 , C12Q1/68 , G01N21/78 , G01N33/52 , G01N33/58
CPC分类号： A61K31/505 , A61K31/506 , C07D307/54 , C07D403/10 , C07D403/14 , C07D405/14 , C09B23/0075 , G01N33/52 , Y10S435/81
摘要： Disclosed is a method of fluorescent detection of a nucleic acid. The method comprises contacting to the nucleic acid a bis-dicationic aryl furan and exposing the nucleic acid to light at a frequency to induce fluorescence of the compound. A method for fluorescent detection of cytoskeleton elements, and novel bis-dicationic aryl furan compounds are also disclosed.
摘要翻译： 公开了一种荧光检测核酸的方法。 所述方法包括使所述核酸与双阳离子芳基呋喃接触，并将所述核酸以一定频率曝光以诱导所述化合物的荧光。 还公开了细胞骨架元件的荧光检测方法，以及新型的双 - 二盐酸芳基呋喃化合物。
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19.发明授权
公开(公告)号：US6156779A
公开(公告)日：2000-12-05
申请号：US477386
申请日：2000-01-04
IPC分类号： C07D401/14 , A61K31/415 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/445 , A61K31/497 , A61K31/505 , A61K31/506 , A61P31/04 , C07D403/14 , C07D405/14
CPC分类号： A61K31/427 , A61K31/4184 , A61K31/422 , A61K31/4439 , A61K31/497 , A61K31/506
摘要： The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.
摘要翻译： 本发明提供了在需要这种治疗的受试者中治疗新型隐球菌和白色念珠菌的方法。 所述方法包括以有效治疗病症的量给予受试者双阳离子双苯并咪唑。
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20.发明授权Methods of combatting infectious disease using dicationic bis-benzimidazoles 有权使用双面双联苯并咪唑打击感染性疾病的方法
公开(公告)号：US5972969A
公开(公告)日：1999-10-26
申请号：US145367
申请日：1998-09-01
IPC分类号： C07D401/14 , A61K31/415 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/445 , A61K31/497 , A61K31/505 , A61K31/506 , A61P31/04 , C07D403/14 , C07D405/14
CPC分类号： A61K31/427 , A61K31/4184 , A61K31/422 , A61K31/4439 , A61K31/497 , A61K31/506
摘要： The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.
摘要翻译： 本发明提供了在需要这种治疗的受试者中治疗新型隐球菌和白色念珠菌的方法。 所述方法包括以有效治疗病症的量给予受试者双阳离子双苯并咪唑。
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