公开(公告)号：US20150328374A1

公开(公告)日：2015-11-19

申请号：US14653137

申请日：2013-12-20

Applicant: DSM IP ASSETS B.V.

Inventor： George MIHOV ,  John Andrew ZUPANCICH

IPC: A61L31/10 ,  C09D177/12 ,  A61L31/16

CPC classification number: A61L31/10 ,  A61L27/18 ,  A61L27/34 ,  A61L27/54 ,  A61L27/58 ,  A61L29/06 ,  A61L29/148 ,  A61L29/16 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  C08G69/44 ,  C08L77/12 ,  C09D177/12 ,  C08L77/00

Abstract: The invention relates to a coating comprising a biodegradable polymer comprising at least two different functional groups pendant to the polymer backbone, which functional groups are selected from the group of carboxyl-, amine, hydroxyl, ester, amide-, thiol- or thioester groups. The two different functional groups comprise at least an unprotected hydrophilic functional group chosen from a carboxyl-, amine, thiol or hydroxyl group and at least a protected hydrophobic functional group chosen from an ester, amide- or thioester group. The invention further relates to an implantable device comprising the coating composition. The implantable device is includes cardiac pacemakers and defibrillators; leads and electrodes for the preceding, organ stimulators such as nerve, bladder, sphincter and diaphragm stimulators, prostheses, rods, vascular grafts, self-expandable stents, balloon-expandable stents, stent-grafts, grafts, catheters, artificial heart valves and cerebrospinal fluid shunts.

Abstract translation: 本发明涉及一种包含可生物降解聚合物的涂层，其包含至少两个垂直于聚合物主链的不同官能团，该官能团选自羧基，胺，羟基，酯，酰胺 - ，硫醇或硫酯基团。 两个不同的官能团包含至少一个选自羧基，胺，硫醇或羟基的未保护的亲水官能团和至少一个选自酯，酰胺或硫酯基团的被保护的疏水官能团。 本发明还涉及包含该涂料组合物的可植入装置。 可植入装置包括心脏起搏器和除颤器; 前列腺的器官刺激器，例如神经，膀胱，括约肌和隔膜刺激器，假体，杆，血管移植物，自扩张支架，球囊扩张支架，支架移植物，移植物，导管，人造心脏瓣膜和脑脊液 流体分流器。