公开(公告)号：US20030096862A1

公开(公告)日：2003-05-22

申请号：US10217580

申请日：2002-08-12

Applicant: Duke University

Inventor： Eric J. Toone ,  Jonathan S. Stamler

IPC: A61K031/21 ,  C07C381/10

CPC classification number: A61L2/23 ,  A61L2/20 ,  A61L29/16 ,  A61L2300/114 ,  A61L2300/216 ,  C07C381/00

Abstract: Disclosed are novel NO-releasing compounds which comprise a stabilized S-nitrosyl group and a free alcohol or a free thiol group. Also disclosed is a method of preparing the NO-releasing compounds. The method comprises reacting a polythiol or a thioalcohol with a nitrosylating agent. Also disclosed are medical devices coated with the disclosed compounds, methods of delivering NO to treatments sites in a subject by utilizing the medical devices and methods of sterilizing surfaces.