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11.发明申请LABELLED PYRROLYL-OXADIAZOLYL-DIAZABICYCLONONANE DERIVATIVES AND THEIR USE IN DIAGNOSTIC METHODS 审中-公开标记的吡咯烷 - 氧杂二苯并二氮杂环戊烯衍生物及其在诊断方法中的应用公开(公告)号：US20120288443A1
公开(公告)日：2012-11-15
申请号：US13509215
申请日：2010-11-09
IPC分类号： C07D487/08 , A61K51/04
CPC分类号： A61K49/10 , A61K51/0468
摘要： The present invention relates to certain labelled pyrrolyl-oxadizolyl-diazabicyclononane derivatives. Furthermore, the present invention relates to the use of said derivatives in their labelled form in diagnostic methods, in particular for in vivo receptor imaging (neuroimaging).
摘要翻译： 本发明涉及某些标记的吡咯基 - 恶唑基 - 二氮杂双环壬烷衍生物。 此外，本发明涉及所述衍生物以其标记形式用于诊断方法，特别是用于体内受体成像（神经成像）的用途。
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公开(公告)号：US20110144008A1
公开(公告)日：2011-06-16
申请号：US12957916
申请日：2010-12-01
IPC分类号： A61K38/26 , C07K14/605 , A61P3/10 , A61P3/04
CPC分类号： C07K14/605 , A61K38/00 , A61K38/26 , A61K47/62 , C07K14/57563
摘要： Novel peptide agonists of GLP-1 activity useful for lowering blood glucose levels. The novel peptides comprise variants of the GLP-1 or the exendin-4 polypeptide sequence and are pharmacologically active and stable. These peptides are useful in the treatment of diseases that benefit from regulation of excess levels of blood glucose and/or regulation of gastric emptying, such as diabetes and eating disorders.
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13.发明申请PHARMACEUTICAL COMPOSITION COMPRISING TESOFENSINE OR ITS ANALOGUE AND AN ANTI-OBESITY COMPOUND 审中-公开包含紫杉醇或其类似物和抗生素化合物的药物组合物公开(公告)号：US20100317572A1
公开(公告)日：2010-12-16
申请号：US12809365
申请日：2008-12-18
IPC分类号： A61K38/22 , A61K31/46 , A61K31/397 , A61K38/26 , A61K31/55 , A61K31/485 , A61K31/5375 , A61K38/28 , A61P1/04
CPC分类号： A61K45/06 , A61K31/46 , A61K2300/00
摘要： This invention relates to novel pharmaceutical compositions comprising a therapeutically effective combination of a compound of Formula I and an anti-obesity compound. The pharmaceutical compositions for use according to the invention are contemplated particularly useful for combating obesity or an obesity associated disease.
摘要翻译： 本发明涉及包含式I化合物和抗肥胖化合物的治疗有效组合的新型药物组合物。 预期根据本发明使用的药物组合物特别可用于抵抗肥胖症或肥胖相关疾病。
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公开(公告)号：US20110118304A1
公开(公告)日：2011-05-19
申请号：US12743546
申请日：2008-11-19
IPC分类号： A61K31/439 , A61P25/30
CPC分类号： A61K31/46
摘要： A method for treating over-eating disorders, in particular Bulimia nervosa, Binge Eating Disorder (BED), and Compulsive Over-Eating. The invention furthermore relates to novel pharmaceutical compositions for the treatment of over-eating disorders comprising a therapeutically effective amount of a compound of formula I.
摘要翻译： 一种治疗过度饮食障碍的方法，特别是神经性惊厥症，BED饮食障碍（BED）和强迫性过度饮食。 本发明还涉及用于治疗过度进食障碍的新型药物组合物，其包含治疗有效量的式I化合物。
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公开(公告)号：US06528486B1
公开(公告)日：2003-03-04
申请号：US09614847
申请日：2000-07-12
IPC分类号： A61K3800
CPC分类号： C07K14/605 , A61K38/00 , A61K38/26 , A61K47/62 , C07K14/57563
摘要： The present invention relates to novel peptide conjugates which have increased stability and are useful in the treatment of excess levels of blood glucose.
摘要翻译： 本发明涉及具有增加的稳定性并可用于治疗过量血糖的新型肽缀合物。
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公开(公告)号：US20110245165A1
公开(公告)日：2011-10-06
申请号：US12770667
申请日：2010-04-29
CPC分类号： C07K14/605 , A61K38/00 , A61K38/26 , A61K47/62 , C07K14/57563
摘要： Novel peptide agonists of GLP-1 activity useful for lowering blood glucose levels. The novel peptides comprise variants of the GLP-1 or the exendin-4 polypeptide sequence and are pharmacologically active and stable. These peptides are useful in the treatment of diseases that benefit from regulation of excess levels of blood glucose and/or regulation of gastric emptying, such as diabetes and eating disorders.
摘要翻译： 用于降低血糖水平的GLP-1活性的新型肽激动剂。 新型肽包含GLP-1或毒蜥外泌肽-4多肽序列的变体，并且具有药理学活性和稳定性。 这些肽可用于治疗受益于调节过量血糖和/或调节胃排空的疾病，例如糖尿病和进食障碍。
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