公开(公告)号：US5593967A

公开(公告)日：1997-01-14

申请号：US41647

申请日：1993-04-01

申请人： David C. Horwell ,  Edward Roberts ,  Ann Holmes ,  Janak K. Padia ,  William H. Roark ,  Bruce D. Roth ,  Bharat K. Trivedi ,  Jurgen Kleinschroth ,  David C. Rees ,  Reginald S. Richardson

发明人： David C. Horwell ,  Edward Roberts ,  Ann Holmes ,  Janak K. Padia ,  William H. Roark ,  Bruce D. Roth ,  Bharat K. Trivedi ,  Jurgen Kleinschroth ,  David C. Rees ,  Reginald S. Richardson

IPC分类号： A61K38/00 ,  C07D209/14 ,  C07D209/20 ,  C07K5/02 ,  C07K5/065 ,  C07K5/078 ,  C07K14/595 ,  C07D209/18 ,  C07D217/00

CPC分类号： C07K14/595 ,  C07D209/14 ,  C07D209/20 ,  C07K5/0202 ,  C07K5/06078 ,  C07K5/06156 ,  A61K38/00

摘要： Novel cholecystokinin antagonists useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the compounds are antianxiety agents and antiulcer agents. They are agents useful for preventing the response to the withdrawal from chronic treatment with use of nicotine, diazepam, alcohol, cocaine, coffee, or opioids. The compounds of the invention are also useful in treating and/or preventing panic. Also disclosed are pharmaceutical compositions and methods of treatment using the antagonists as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds in diagnostic compositions.

摘要翻译： 新颖的缩胆囊素拮抗剂可用作治疗肥胖的药物，胃肠胃分泌过多，胃泌素依赖性肿瘤或抗精神病药。 此外，化合物是抗焦虑剂和抗溃疡剂。 它们是用于防止使用尼古丁，地西泮，酒精，可卡因，咖啡或阿片样物质从慢性治疗中撤回的反应的药剂。 本发明的化合物也可用于治疗和/或预防恐慌。 还公开了使用拮抗剂的药物组合物和治疗方法以及制备它们的方法和可用于其制备的新型中间体。 本发明的另一个特征是本发明化合物在诊断组合物中的用途。