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公开(公告)号：US5580556A
公开(公告)日：1996-12-03
申请号：US367819
申请日：1995-01-03
Applicant: David F. Horrobin
Inventor： David F. Horrobin
Abstract: The use of one or more of gamma-linolenic acid, dihomo-gamma-linolenic acid and arachidonic acid for the manufacture of a medicament for use in enhancement of the anti-viral, anti-cancer or anti-inflammatory effects of interferons; the medicament containing or being for use with a medicament containing one or more interferons when not solely for enhancement of the effect of endogenous interferons.
Abstract translation: 使用一种或多种γ-亚麻酸，二氢-γ-亚麻酸和花生四烯酸来制造用于增强干扰素抗病毒，抗癌或抗炎作用的药物; 所述药物含有或用于含有一种或多种干扰素的药物，而不仅仅是为了增强内源性干扰素的作用。
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公开(公告)号：US5516801A
公开(公告)日：1996-05-14
申请号：US365171
申请日：1994-12-28
Applicant: David F. Horrobin , Brenda E. Reynolds
Inventor： David F. Horrobin , Brenda E. Reynolds
IPC: A61K31/20
CPC classification number: A61K31/20
Abstract: Prevention and/or treatment of abnormal calcification in any tissue by the administration of (i) GLA and/or its EFA metabolites, and in particular the rapidly produced DGLA and/or (ii) EPA and/or its precursors, stearidonic acid and 20:4 n-3, and metabolites, docosahexaenoic acid (DHA) or docosapenmenoic acid (22:5 n-3), as such or in salt or other pharmacologically acceptable form. This is especially suitable for prevention or treatment of nephrocalcinosis and/or renal stones.
Abstract translation: 通过施用（i）GLA和/或其EFA代谢物，特别是快速产生的DGLA和/或（ii）EPA和/或其前体，十八碳四烯酸和20 ：4 n-3，以及代谢物，二十二碳六烯酸（DHA）或二十二碳二烯酸（22：5 n-3），或盐或其他药理学上可接受的形式。 这特别适用于预防或治疗肾钙质沉着症和/或肾结石。
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公开(公告)号：US5380757A
公开(公告)日：1995-01-10
申请号：US61110
申请日：1993-05-14
Applicant: David F. Horrobin
Inventor： David F. Horrobin
CPC classification number: A61K31/20
Abstract: Gamma-linolenic (GLA) and/or dihomo-gamma-linolenic acid (DGLA) may be used in the treatment of vulvar dystrophy and/or vaginal dryness. Other essential fatty acids of the n-6 or n-3 series may also be used in association with GLA and/or DGLA.
Abstract translation: γ-亚麻酸（GLA）和/或二氢-γ-亚麻酸（DGLA）可用于治疗外阴营养不良和/或阴道干燥。 n-6或n-3系列的其他必需脂肪酸也可以与GLA和/或DGLA结合使用。
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公开(公告)号：US5223271A
公开(公告)日：1993-06-29
申请号：US765008
申请日：1991-09-24
Applicant: David F. Horrobin
Inventor： David F. Horrobin
IPC: A61K9/06 , A61K31/17 , A61K31/19 , A61K31/20 , A61K31/202 , A61K31/505 , A61K31/60 , A61K31/63 , A61K33/00 , A61K33/14 , A61K47/20 , A61P17/00 , A61P31/12 , A61P43/00 , C01D3/04 , C01D7/00 , C07C55/10 , C07C57/12 , C07D239/557
CPC classification number: A61K9/0014 , A61K31/19 , A61K31/20 , A61K31/505 , A61K31/60 , A61K31/63 , A61K33/00 , A61K33/14 , A61K47/20
Abstract: The present invention provides a method of treatment and/or prophylaxis of the human or animal body to combat Molluscum Contagiosum, said treatment comprising topically administering a therapeutically or prophylactically effective amount of a physiologically acceptable lithium compound to affected areas on said body.It also extends to pharmaceutical compositions comprising a physiologically acceptable lithium compound together with at least one keratolytic and/or skin penetration assisting agent and at least one pharmaceutically acceptable carrier or excipient.
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公开(公告)号：US5128152A
公开(公告)日：1992-07-07
申请号：US711104
申请日：1991-06-03
Applicant: David F. Horrobin , Michel E. Begin
Inventor： David F. Horrobin , Michel E. Begin
Abstract: Pharmaceutically acceptable compositions of one or more n-6 or n-3 essential fatty acids, particularly gamma-linolenic acid, dihomo-gamma-linolenic acid, or eicosapentaenoic acid, and assimilable iron compounds, in dosage unit form optionally with a diluent or carrier, said acids being present as such or as derivatives convertible in the body thereto and the amounts of said acids or derivatives being 1 mg to 100 g (calculated as gamma-linolenic acid) and of said iron compounds 0.1 mg to 10 g (calculated as iron) or submultiples of said amounts convenient for daily administration thereof.
Abstract translation: 一种或多种n-6或n-3必需脂肪酸，特别是γ-亚麻酸，二氢-γ-亚麻酸或二十碳五烯酸和可同化铁化合物的药学上可接受的组合物以剂量单位形式任选地含有稀释剂或载体 所述酸以本身的形式存在或作为在体内可转化为衍生物的衍生物，所述酸或衍生物的量为1mg至100g（以γ-亚麻酸计算）和所述铁化合物0.1mg至10g（以 铁）或所述量的次数便于日常给药。
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Patent Agency Ranking
公开(公告)号：US4758592A
公开(公告)日：1988-07-19
申请号：US911719
申请日：1986-09-26
Applicant: David F. Horrobin , Robert A. Casper
Inventor： David F. Horrobin , Robert A. Casper
Abstract: Method of prevention or treatment of endometriosis wherein effective amounts of one or both of (i) gamma-linolenic acid and/or dihomo-gamma-linolenic acid and (ii) 18:4 n-3 and/or one or more of the metabolites of 18:4 n-3 (20:4 n-3, 20:5 n-3, 22:5 n-3 or 22:6 n-3) are administered against endometriosis as such or in the form of an ester, salt, amide or other derivative convertible in the body thereto, alone or in an acceptable pharmaceutical carrier or diluent.
Abstract translation: 预防或治疗子宫内膜异位症的方法，其中有效量的（i）γ-亚麻酸和/或二 - γ-亚麻酸和（ii）18：4n-3和/或一种或多种代谢物中的一种或两种 18：4 n-3（20：4 n-3,20：5 n-3,22：5 n-3或22：6 n-3）与子宫内膜异位症一起施用或以酯的形式施用， 盐，酰胺或其它可衍生于体内的衍生物，单独或在可接受的药物载体或稀释剂中。
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公开(公告)号：US4328243A
公开(公告)日：1982-05-04
申请号：US251901
申请日：1981-04-07
Applicant: David F. Horrobin , Julian Lieb
Inventor： David F. Horrobin , Julian Lieb
Abstract: A method for the treatment and/or prophylaxis of the side-effects of lithium treatment in a subject suffering from manic-depressive psychosis, which method comprises administering to the subject an effective amount therefor of dihomogamma-linolenic acid and/or a biosynthetic precursor thereof.
Abstract translation: 一种用于治疗和/或预防患有躁狂抑郁精神病的受试者的锂处理的副作用的方法，该方法包括向受试者施用有效量的二羟基亚麻酸和/或其生物合成前体 。
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公开(公告)号：US5763484A
公开(公告)日：1998-06-09
申请号：US823790
申请日：1997-03-24
Applicant: David F. Horrobin
Inventor： David F. Horrobin
IPC: A61K31/19 , A23D9/00 , A23L1/30 , A23L1/325 , A23L1/48 , A61K31/16 , A61K31/20 , A61K31/22 , A61K31/23 , A61K31/557 , A61K35/56 , A61K35/60 , A61K36/00 , A61K36/185 , A61K38/00 , A61P3/08 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/30 , A61P27/16 , A61P35/00 , A61P37/08
CPC classification number: A61K35/60 , A23D9/00 , A61K31/20 , A61K31/23 , A61K31/557 , A61K36/185 , Y10S514/861 , Y10S514/866
Abstract: A method of treatment of a disorder, including breast cancer and other cancer, with effective amounts of one or more of the metabolites of linoleic acid (GLA, DGLA, AA, 22:4n-y or 22:5n-6) and one or more of the metabolites of .alpha.-linolenic acid (18:4n-3, 20:4n-3, 20:5n-3, 22:5n-3 or 22:6n-3) administered as such or in the form of an ester, salt, amide or other derivative convertible in the body thereto alone or in acceptable pharmaceutical carrier or diluent.
Abstract translation: 一种治疗包括乳腺癌和其他癌症的病症的方法，其有效量的一种或多种亚油酸代谢物（GLA，DGLA，AA，22：4n-y或22：5n-6）和一种或多种 更多的如此给予的α-亚麻酸（18：4n-3,20：4n-3,20：5n-3,22：5n-3或22：6n-3）的代谢物或酯的形式 ，盐，酰胺或其它可在体内转化为其的衍生物，或在可接受的药物载体或稀释剂中。
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19.发明授权
公开(公告)号：US5614208A
公开(公告)日：1997-03-25
申请号：US600004
申请日：1996-02-14
Applicant: David F. Horrobin , Yung-Sheng Huang
Inventor： David F. Horrobin , Yung-Sheng Huang
IPC: A61K31/23 , A23D9/00 , A23L1/30 , A61K8/00 , A61K8/30 , A61K8/37 , A61K8/96 , A61P13/02 , A61P15/00 , A61P17/00 , A61P25/04 , A61Q5/00 , A61Q19/00 , C07C69/587 , C11B3/10 , C11B7/00 , C11D3/06 , A61K9/70 , A61K9/14 , A61K31/20 , A61K47/12
CPC classification number: A23D9/00 , A61K31/23 , C07C69/587
Abstract: Atopic eczema, breast pain or premenstrual syndrome are treated by administering to a person in need of same a composition containing at least 20% di-linoleoyl-mono-gamma-linolenyl glycerol by weight.
Abstract translation: 特应性湿疹，乳房疼痛或经前期综合征通过给予需要相同组合物的人治疗，所述组合物含有至少20％重量的二亚油酰基单一γ-亚麻醇甘油。
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20.发明授权
公开(公告)号：US5552150A
公开(公告)日：1996-09-03
申请号：US158986
申请日：1993-11-30
Applicant: David F. Horrobin , Yung-Sheng Huang
Inventor： David F. Horrobin , Yung-Sheng Huang
IPC: A61K31/23 , A23D9/00 , A23L1/30 , A61K8/00 , A61K8/30 , A61K8/37 , A61K8/96 , A61P13/02 , A61P15/00 , A61P17/00 , A61P25/04 , A61Q5/00 , A61Q19/00 , C07C69/587 , C11B3/10 , C11B7/00 , C11D3/06 , A61K31/20 , A61K9/14 , A61K47/12
CPC classification number: A23D9/00 , A61K31/23 , C07C69/587
Abstract: A natural or synthetic glycerol oil which comprises at least 20% by weight, preferably at least 25% of di-linoleoyl-mono-gamma-linolenyl-glycerol (DLMG), is used to supplement foods, nutritional compositions and in skin and hair care compositions.
Abstract translation: 使用包含至少20重量％，优选至少25％的二亚油酰 - 单γ-亚麻油烯甘油（DLMG）的天然或合成甘油油来补充食物，营养组合物和皮肤和头发护理 组合物。
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