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公开(公告)号：US07396664B2
公开(公告)日：2008-07-08
申请号：US11204709
申请日：2005-08-16
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要： Nucleic acid molecules and multimeric proteins capable of binding vascular endothelial growth factor (VEGF). VEGF traps are disclosed which are therapeutically useful for treating VEGF-associated conditions and diseases, and are specifically designed for local administration to specific organs, tissues, and/or cells.
摘要翻译： 能够结合血管内皮生长因子（VEGF）的核酸分子和多聚体蛋白质。 公开了可用于治疗VEGF相关病症和疾病的VEGF陷阱，其专门用于局部给予特定器官，组织和/或细胞。
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公开(公告)号：US20100087632A1
公开(公告)日：2010-04-08
申请号：US12623869
申请日：2009-11-23
IPC分类号： C07K19/00
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/00
摘要： Fusion proteins which bind and inhibit vascular endothelial growth factor (VEGF). The VEGF-binding fusion proteins are therapeutically useful for treating VEGF-associated conditions and diseases, and are specifically designed for local administration to specific organs, tissues, and/or cells.
摘要翻译： 结合并抑制血管内皮生长因子（VEGF）的融合蛋白。 VEGF结合融合蛋白在治疗VEGF相关病症和疾病中是治疗上有用的，并且被特别设计用于局部给予特定器官，组织和/或细胞。
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公开(公告)号：US07399612B2
公开(公告)日：2008-07-15
申请号：US11346008
申请日：2006-02-02
摘要： Nucleic acid molecules encoding fusion proteins which bind and inhibit vascular endothelial growth factor (VEGF). The VEGF-binding fusion proteins are therapeutically useful for treating VEGF-associated conditions and diseases, and are specifically designed for local administration to specific organs, tissues, and/or cells.
摘要翻译： 编码结合并抑制血管内皮生长因子（VEGF）的融合蛋白的核酸分子。 VEGF结合融合蛋白在治疗VEGF相关病症和疾病中是治疗上有用的，并且被特别设计用于局部给予特定器官，组织和/或细胞。
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公开(公告)号：US07279159B2
公开(公告)日：2007-10-09
申请号：US10880021
申请日：2004-06-29
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/00
摘要： Nucleic acid molecules and multimeric proteins capable of binding vascular endothelial growth factor (VEGF). VEGF traps are disclosed which are therapeutically useful for treating VEGF-associated conditions and diseases, and are specifically designed for local administration to specific organs, tissues, and/or cells.
摘要翻译： 能够结合血管内皮生长因子（VEGF）的核酸分子和多聚体蛋白质。 公开了可用于治疗VEGF相关病症和疾病的VEGF陷阱，其专门用于局部给予特定器官，组织和/或细胞。
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公开(公告)号：US07087411B2
公开(公告)日：2006-08-08
申请号：US10609775
申请日：2003-06-30
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/00
摘要： Nucleic acid molecules and multimeric proteins capable of binding vascular endothelial growth factor (VEGF). VEGF mini-traps are disclosed which are therapeutically useful for treating VEGF-associated conditions and diseases, and are specifically designed for local administration to specific organs, tissues, and/or cells.
摘要翻译： 能够结合血管内皮生长因子（VEGF）的核酸分子和多聚体蛋白质。 公开了VEGF微型陷阱，其可用于治疗VEGF相关病症和疾病，并且被特别设计用于特定器官，组织和/或细胞的局部给药。
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公开(公告)号：US07972598B2
公开(公告)日：2011-07-05
申请号：US12623869
申请日：2009-11-23
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/00
摘要： Fusion proteins which bind and inhibit vascular endothelial growth factor (VEGF). The VEGF-binding fusion proteins are therapeutically useful for treating VEGF-associated conditions and diseases, and are specifically designed for local administration to specific organs, tissues, and/or cells.
摘要翻译： 结合并抑制血管内皮生长因子（VEGF）的融合蛋白。 VEGF结合融合蛋白在治疗VEGF相关病症和疾病中是治疗上有用的，并且被特别设计用于局部给予特定器官，组织和/或细胞。
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公开(公告)号：US07635474B2
公开(公告)日：2009-12-22
申请号：US12135549
申请日：2008-06-09
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/00
摘要： Nucleic acid molecules encoding fusion proteins which bind and inhibit vascular endothelial growth factor (VEGF). The VEGF-binding fusion proteins are therapeutically useful for treating VEGF-associated conditions and diseases, and are specifically designed for local administration to specific organs, tissues, and/or cells.
摘要翻译： 编码结合并抑制血管内皮生长因子（VEGF）的融合蛋白的核酸分子。 VEGF结合融合蛋白在治疗VEGF相关病症和疾病中是治疗上有用的，并且被特别设计用于局部给予特定器官，组织和/或细胞。
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公开(公告)号：US06458999B1
公开(公告)日：2002-10-01
申请号：US09722197
申请日：2000-11-27
IPC分类号： C07C21742
CPC分类号： C07C217/08
摘要： The present invention is related to a series of derivatives of novel ether diamine compounds prepared by the cyanobutylation reaction of an alcohol having 3 to 22 carbon atoms with 2-pentenenitrile to form a branched alkyl ether nitrile. The etheraminonitriles formed by the process are hydrogenated to form alkylether amines. The resulting product can be reacted with 2-pentenenitrile and or acrylonitrile and in a subsequent step, hydrogenated to yield a diamine. Specifically, the present invention deals with two types of tertiary amines one made by the reaction of novel ether diamines compounds with ethylene oxide, propylene oxide or butylene oxide or mixtures thereof, producing alkoxylated tertiary amines and the other made by the reaction of novel ether amine compounds with formaldehyde and hydrogen producing methylated tertiary amines. The invention also disclosed novel amine oxides, and quaternary compounds made from said tertiary amines.
摘要翻译： 本发明涉及通过具有3至22个碳原子的醇与2-戊烯腈的氰基丁基化反应制备的一系列新型醚二胺化合物的衍生物，以形成支链烷基醚腈。 通过该方法形成的醚氨基腈被氢化形成烷基醚胺。 所得产物可与2-戊烯腈和/或丙烯腈反应，并在随后的步骤中氢化得到二胺。 具体地，本发明涉及通过新型醚二胺化合物与环氧乙烷，环氧丙烷或环氧丁烷或其混合物的反应制备的两种类型的叔胺，其产生烷氧基化叔胺，另一种通过新的醚胺 化合物与甲醛和氢气产生甲基化叔胺。 本发明还公开了新的氧化胺和由所述叔胺制成的季铵化合物。
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公开(公告)号：US06426436B1
公开(公告)日：2002-07-30
申请号：US10051675
申请日：2002-01-22
IPC分类号： C07C21163
CPC分类号： C07C217/08
摘要： The present invention is related to a series of derivatives of novel ether diamine compounds prepared by the cynobutylation reaction of an alcohol having 3 to 22 carbon atoms with 2-pentenenitrile to form a branched alkyl ether nitrile. The etheraminonitriles formed by the process are hydrogenated to form alkylether amines. The resulting product can be reacted with 2-pentenenitrile and or acrylonitrile and in subsequent step, hydrogenated to yield a diamine. Specifically, the present invention deals with two types of tertiary amines one made by the reaction of novel ether diamines compounds with ethylene oxide, propylene oxide or butylene oxide or mixtures thereof, producing alkoxylated tertiary amines and the other made by the reaction of novel ether amine compounds with formaldehyde and hydrogen producing methylated tertiary amines. The invention also disclosed novel amine oxides, and quaternary compounds made from said tertiary amines.
摘要翻译： 本发明涉及通过具有3至22个碳原子的醇与2-戊烯腈的异辛基化反应制备的一系列新型醚二胺化合物的衍生物，以形成支链烷基醚腈。 通过该方法形成的醚氨基腈被氢化形成烷基醚胺。 所得产物可与2-戊烯腈和/或丙烯腈反应，并在随后的步骤中氢化得到二胺。 具体地，本发明涉及通过新型醚二胺化合物与环氧乙烷，环氧丙烷或环氧丁烷或其混合物的反应制备的两种类型的叔胺，其产生烷氧基化叔胺，另一种通过新的醚胺 化合物与甲醛和氢气产生甲基化叔胺。 本发明还公开了新的氧化胺和由所述叔胺制成的季铵化合物。
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公开(公告)号：US06417401B1
公开(公告)日：2002-07-09
申请号：US10051656
申请日：2002-01-22
IPC分类号： C07C29104
CPC分类号： C07C217/08
摘要： The present invention is related to a series of derivatives of novel ether diamine compounds prepared by the cyanobutylation reaction of an alcohol having 3 to 22 carbon atoms with 2-pentenenitrile to form a branched alkyl ether nitrile. The etheraminonitriles formed by the process are hydrogenated to form alkylether amines. The resulting product can be reacted with 2-pentenenitrile and or acrylonitrile and in a subsequent step, hydrogenated to yield a diamine. Specifically, the present invention deals with two types of tertiary amines one made by the reaction of novel ether diamines compounds with ethylene oxide, propylene oxide or butylene oxide or mixtures thereof, producing alkoxylated tertiary amines and the other made by the reaction of novel ether amine compounds with formaldehyde and hydrogen producing methylated tertiary amines. The invention also disclosed novel amine oxides, and quaternary compounds made from said tertiary amines.
摘要翻译： 本发明涉及通过具有3至22个碳原子的醇与2-戊烯腈的氰基丁基化反应制备的一系列新型醚二胺化合物的衍生物，以形成支链烷基醚腈。 通过该方法形成的醚氨基腈被氢化形成烷基醚胺。 所得产物可与2-戊烯腈和/或丙烯腈反应，并在随后的步骤中氢化得到二胺。 具体地，本发明涉及通过新型醚二胺化合物与环氧乙烷，环氧丙烷或环氧丁烷或其混合物的反应制备的两种类型的叔胺，其产生烷氧基化叔胺，另一种通过新的醚胺 化合物与甲醛和氢气产生甲基化叔胺。 本发明还公开了新的氧化胺和由所述叔胺制成的季铵化合物。
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