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公开(公告)号：US06458999B1
公开(公告)日：2002-10-01
申请号：US09722197
申请日：2000-11-27
IPC分类号： C07C21742
CPC分类号： C07C217/08
摘要： The present invention is related to a series of derivatives of novel ether diamine compounds prepared by the cyanobutylation reaction of an alcohol having 3 to 22 carbon atoms with 2-pentenenitrile to form a branched alkyl ether nitrile. The etheraminonitriles formed by the process are hydrogenated to form alkylether amines. The resulting product can be reacted with 2-pentenenitrile and or acrylonitrile and in a subsequent step, hydrogenated to yield a diamine. Specifically, the present invention deals with two types of tertiary amines one made by the reaction of novel ether diamines compounds with ethylene oxide, propylene oxide or butylene oxide or mixtures thereof, producing alkoxylated tertiary amines and the other made by the reaction of novel ether amine compounds with formaldehyde and hydrogen producing methylated tertiary amines. The invention also disclosed novel amine oxides, and quaternary compounds made from said tertiary amines.
摘要翻译： 本发明涉及通过具有3至22个碳原子的醇与2-戊烯腈的氰基丁基化反应制备的一系列新型醚二胺化合物的衍生物，以形成支链烷基醚腈。 通过该方法形成的醚氨基腈被氢化形成烷基醚胺。 所得产物可与2-戊烯腈和/或丙烯腈反应，并在随后的步骤中氢化得到二胺。 具体地，本发明涉及通过新型醚二胺化合物与环氧乙烷，环氧丙烷或环氧丁烷或其混合物的反应制备的两种类型的叔胺，其产生烷氧基化叔胺，另一种通过新的醚胺 化合物与甲醛和氢气产生甲基化叔胺。 本发明还公开了新的氧化胺和由所述叔胺制成的季铵化合物。
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公开(公告)号：US06426436B1
公开(公告)日：2002-07-30
申请号：US10051675
申请日：2002-01-22
IPC分类号： C07C21163
CPC分类号： C07C217/08
摘要： The present invention is related to a series of derivatives of novel ether diamine compounds prepared by the cynobutylation reaction of an alcohol having 3 to 22 carbon atoms with 2-pentenenitrile to form a branched alkyl ether nitrile. The etheraminonitriles formed by the process are hydrogenated to form alkylether amines. The resulting product can be reacted with 2-pentenenitrile and or acrylonitrile and in subsequent step, hydrogenated to yield a diamine. Specifically, the present invention deals with two types of tertiary amines one made by the reaction of novel ether diamines compounds with ethylene oxide, propylene oxide or butylene oxide or mixtures thereof, producing alkoxylated tertiary amines and the other made by the reaction of novel ether amine compounds with formaldehyde and hydrogen producing methylated tertiary amines. The invention also disclosed novel amine oxides, and quaternary compounds made from said tertiary amines.
摘要翻译： 本发明涉及通过具有3至22个碳原子的醇与2-戊烯腈的异辛基化反应制备的一系列新型醚二胺化合物的衍生物，以形成支链烷基醚腈。 通过该方法形成的醚氨基腈被氢化形成烷基醚胺。 所得产物可与2-戊烯腈和/或丙烯腈反应，并在随后的步骤中氢化得到二胺。 具体地，本发明涉及通过新型醚二胺化合物与环氧乙烷，环氧丙烷或环氧丁烷或其混合物的反应制备的两种类型的叔胺，其产生烷氧基化叔胺，另一种通过新的醚胺 化合物与甲醛和氢气产生甲基化叔胺。 本发明还公开了新的氧化胺和由所述叔胺制成的季铵化合物。
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公开(公告)号：US06417401B1
公开(公告)日：2002-07-09
申请号：US10051656
申请日：2002-01-22
IPC分类号： C07C29104
CPC分类号： C07C217/08
摘要： The present invention is related to a series of derivatives of novel ether diamine compounds prepared by the cyanobutylation reaction of an alcohol having 3 to 22 carbon atoms with 2-pentenenitrile to form a branched alkyl ether nitrile. The etheraminonitriles formed by the process are hydrogenated to form alkylether amines. The resulting product can be reacted with 2-pentenenitrile and or acrylonitrile and in a subsequent step, hydrogenated to yield a diamine. Specifically, the present invention deals with two types of tertiary amines one made by the reaction of novel ether diamines compounds with ethylene oxide, propylene oxide or butylene oxide or mixtures thereof, producing alkoxylated tertiary amines and the other made by the reaction of novel ether amine compounds with formaldehyde and hydrogen producing methylated tertiary amines. The invention also disclosed novel amine oxides, and quaternary compounds made from said tertiary amines.
摘要翻译： 本发明涉及通过具有3至22个碳原子的醇与2-戊烯腈的氰基丁基化反应制备的一系列新型醚二胺化合物的衍生物，以形成支链烷基醚腈。 通过该方法形成的醚氨基腈被氢化形成烷基醚胺。 所得产物可与2-戊烯腈和/或丙烯腈反应，并在随后的步骤中氢化得到二胺。 具体地，本发明涉及通过新型醚二胺化合物与环氧乙烷，环氧丙烷或环氧丁烷或其混合物的反应制备的两种类型的叔胺，其产生烷氧基化叔胺，另一种通过新的醚胺 化合物与甲醛和氢气产生甲基化叔胺。 本发明还公开了新的氧化胺和由所述叔胺制成的季铵化合物。
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公开(公告)号：US06331648B1
公开(公告)日：2001-12-18
申请号：US09566505
申请日：2000-05-08
IPC分类号： C07C21728
CPC分类号： C07C217/08
摘要： The present invention relates to a series of derivatives of novel ether amine compounds prepared by the cyanobutylation reaction of an alcohol having 3 to 22 carbon atoms with 2-pentenenitrile to form a branched alkyl ether nitrile. The alkyl ether nitrites formed by the process are hydrogenated to form alkylether amines. The resulting product can be reacted with 2-pentenenitrile and or acrylonitrile and in a subsequent step, hydrogenated to yield a diamine. Specifically, the present invention deals with two types of tertiary amines one made by the reaction of novel ether amine compounds with ethylene oxide, propylene oxide or butylene oxide or mixtures thereof producing alkoxylated tertiary amines and the other made by the reaction of novel ether amine compounds with formaldehyde and hydrogen producing methylated tertiary amines. The invention also discloses novel amine oxides, and quaternary compounds made from said tertiary amines.
摘要翻译： 本发明涉及通过具有3至22个碳原子的醇与2-戊烯腈的氰基丁基化反应制备的一系列新的醚胺化合物的衍生物，以形成支链烷基醚腈。 通过该方法形成的烷基醚亚硝酸盐被氢化形成烷基醚胺。 所得产物可与2-戊烯腈和/或丙烯腈反应，并在随后的步骤中氢化得到二胺。 具体地，本发明涉及通过新型醚胺化合物与环氧乙烷，环氧丙烷或环氧丁烷或其混合物的反应制备烷氧基化叔胺而制备的两种叔胺，另一种由新的醚胺化合物 与甲醛和氢气产生甲基化叔胺。 本发明还公开了新的氧化胺和由所述叔胺制成的季铵化合物。
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公开(公告)号：US6114585A
公开(公告)日：2000-09-05
申请号：US459562
申请日：1999-12-13
申请人： Thomas J. Daly , Anita Mokadam Sorhaug , Robert E. Harbour, Jr. , Abraham A. Zahand , Michael Clumpner , Anthony J. O'Lenick, Jr.
发明人： Thomas J. Daly , Anita Mokadam Sorhaug , Robert E. Harbour, Jr. , Abraham A. Zahand , Michael Clumpner , Anthony J. O'Lenick, Jr.
IPC分类号： C07C217/08 , C07C217/28 , C07C217/42
CPC分类号： C07C217/08
摘要： The present invention relates to a series of novel ether amine compounds prepared by the cyanobutylation reaction of an alcohol having 12 to 26 carbon atoms with 2-pentenenitrile to form a branched alkyl ether nitrile. The etheraminonitriles formed by the process are hydrogenated to form alkylether amines. The resulting product can be reacted with 2-pentenenitrile and hydrogenated to yield a polyamine.
摘要翻译： 本发明涉及通过具有12-26个碳原子的醇与2-戊烯腈的氰基丁基化反应制备的一系列新的醚胺化合物，以形成支链烷基醚腈。 通过该方法形成的醚氨基腈被氢化形成烷基醚胺。 所得产物可与2-戊烯腈反应并氢化得到多胺。
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公开(公告)号：US07396664B2
公开(公告)日：2008-07-08
申请号：US11204709
申请日：2005-08-16
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要： Nucleic acid molecules and multimeric proteins capable of binding vascular endothelial growth factor (VEGF). VEGF traps are disclosed which are therapeutically useful for treating VEGF-associated conditions and diseases, and are specifically designed for local administration to specific organs, tissues, and/or cells.
摘要翻译： 能够结合血管内皮生长因子（VEGF）的核酸分子和多聚体蛋白质。 公开了可用于治疗VEGF相关病症和疾病的VEGF陷阱，其专门用于局部给予特定器官，组织和/或细胞。
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公开(公告)号：US08445434B2
公开(公告)日：2013-05-21
申请号：US13416481
申请日：2012-03-09
IPC分类号： A61K39/395 , A61P3/10
CPC分类号： C07K14/65 , A61K38/30 , C07K2319/00 , C07K2319/30 , C07K2319/75
摘要： A fusion protein comprising at least one IGF1 variant component and a fusion component (F), and, optionally, a signal sequence, exhibits improved stability relative to the native IGF1 or IGF2 polypeptide. The fusion component (F) may be a multimerizing component, such as an immunoglobulin domain, in particular, the Fc domain of IgG or a heavy chain of IgG. IGF1 variants were shown to have improved ability to increase muscle mass in a subject suffering from muscle atrophy caused by cachexia, immobilization, aging, chronic disease, cancer, hereditary condition, an atrophy-causing agent, and the like. IGF1 variants are also effective in decreasing blood glucose in a subject suffering from diabetes or hyperglycemia.
摘要翻译： 包含至少一种IGF1变体组分和融合组分（F）以及任选的信号序列的融合蛋白相对于天然IGF1或IGF2多肽表现出改进的稳定性。 融合组分（F）可以是多聚化组分，例如免疫球蛋白结构域，特别是IgG的Fc结构域或IgG的重链。 IGF1变体显示具有改善的能力，以增加受到恶病质，固定化，老化，慢性疾病，癌症，遗传性疾病，引起萎缩症等引起的肌肉萎缩的受试者的肌肉质量的增加。 IGF1变体在降低患有糖尿病或高血糖症的受试者中的血糖中也是有效的。
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公开(公告)号：US20080220004A1
公开(公告)日：2008-09-11
申请号：US11998709
申请日：2007-11-30
申请人： Stanley J. Wiegand , Nicholas J. Papadopoulos , George D. Yancopoulos , James P. Fandl , Thomas J. Daly
发明人： Stanley J. Wiegand , Nicholas J. Papadopoulos , George D. Yancopoulos , James P. Fandl , Thomas J. Daly
IPC分类号： A61K39/395 , A61K38/02
CPC分类号： C07K14/71 , A61K38/00 , A61K38/179 , C07K14/47 , C07K2319/00 , C07K2319/30
摘要： Modified chimeric polypeptides with improved pharmacokinetics and improved tissue penetration are disclosed useful for treating eye disorders, including age-related macular degeneration and diabetic retinopathy.
摘要翻译： 公开了具有改善的药物动力学和改善的组织穿透的修饰的嵌合多肽，其可用于治疗眼睛疾病，包括年龄相关性黄斑变性和糖尿病性视网膜病变。
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公开(公告)号：US07399612B2
公开(公告)日：2008-07-15
申请号：US11346008
申请日：2006-02-02
摘要： Nucleic acid molecules encoding fusion proteins which bind and inhibit vascular endothelial growth factor (VEGF). The VEGF-binding fusion proteins are therapeutically useful for treating VEGF-associated conditions and diseases, and are specifically designed for local administration to specific organs, tissues, and/or cells.
摘要翻译： 编码结合并抑制血管内皮生长因子（VEGF）的融合蛋白的核酸分子。 VEGF结合融合蛋白在治疗VEGF相关病症和疾病中是治疗上有用的，并且被特别设计用于局部给予特定器官，组织和/或细胞。
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公开(公告)号：US07396918B2
公开(公告)日：2008-07-08
申请号：US11327555
申请日：2006-01-06
CPC分类号： C07K14/65 , A61K38/30 , C07K2319/00 , C07K2319/30 , C07K2319/75
摘要： A fusion protein comprising at least one IGF1 variant component and a fusion component (F), and, optionally, a signal sequence, exhibiting improved stability relative to the native IGF1 or IGF2 polypeptide. The fusion component (F) may be a multimerizing component, a targeting ligand, or another active or therapeutic compound. IGF1 variants were shown to have improved ability to induce skeletal muscle hypertrophy relative to native IGF1.
摘要翻译： 包含至少一种IGF1变体组分和融合组分（F）以及任选的信号序列的融合蛋白，其相对于天然IGF1或IGF2多肽表现出改进的稳定性。 融合组分（F）可以是多聚化组分，靶向配体或另一种活性或治疗化合物。 IGF1变体显示相对于天然IGF1具有改善的诱导骨骼肌肥大的能力。
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