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公开(公告)号：US09149609B2
公开(公告)日：2015-10-06
申请号：US12152367
申请日：2008-05-14
IPC分类号： A61M29/00 , A61M25/06 , A61B17/22 , A61B17/221 , A61B17/00 , A61F2/01 , A61M25/00 , A61M25/01 , A61M25/10
CPC分类号： A61M25/0662 , A61B17/22031 , A61B17/221 , A61B2017/00867 , A61B2017/22044 , A61B2017/22067 , A61B2017/22094 , A61F2002/011 , A61M25/005 , A61M2025/0175 , A61M2025/1052
摘要： The general purpose of the present invention is to provide a catheter for removal of an organized embolic thrombus, preferably in conjunction with a distal occlusion balloon guidewire. The present invention consists of three main components including a capture/delivery sheath, a capture sleeve of mesh attached to a tube and a grasping mechanism attached to another tube which is central to the other components. Operative structures in the form of manifolds are connected to such components in order to manipulate and control the relative positions of the capture/delivery sheath, the capture sleeve and the grasping mechanism. An embolic thrombus is engaged by the deployable automatically expanding serrated fingers of a grasping mechanism in combination with a deployable automatically expanding mesh capture sleeve. The capture/delivery sheath is maneuvered to cause compression of the serrated fingers and of the mesh capture sleeve for subsequent removal of the embolic thrombus.
摘要翻译： 本发明的总体目的是提供一种用于去除有组织的栓塞性血栓的导管，优选与远端阻塞气囊导丝结合。 本发明包括三个主要部件，包括捕获/传送鞘，连接到管的网的捕获套管和附接到另一个组件中心的另一管的抓握机构。 歧管形式的操作结构连接到这些部件上，以便操纵和控制捕获/传送鞘，捕获套管和把持机构的相对位置。 栓塞血栓由可部署的自动扩张的抓握机构的锯齿状手指与可展开的自动扩张的网状捕获套管结合。 捕获/传送鞘被操纵以引起锯齿状手指和网状物捕获套筒的压缩，以便随后去除栓塞血栓。
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公开(公告)号：US20080275383A1
公开(公告)日：2008-11-06
申请号：US10910108
申请日：2004-08-02
CPC分类号： A61B17/32037 , A61B17/22 , A61B2017/22084 , Y10T29/49826
摘要： A miniature cross stream thrombectomy catheter useful in small blood vessel thrombectomy procedures. An annulus near the distal end of the miniature cross stream thrombectomy catheter is formed between a hypo-tube and a proximally directed bore of a concentrically aligned flow director whereby jet orifices in the hypo-tube communicate with the annulus to direct jet flows of saline or other fluid around and about the annulus and to be directed proximally from the annulus to pass through one or more outflow orifices and thence to pass through one or more inflow orifices thereby creating an ablation flow therebetween which loosens and carries away thrombotic materials from the walls of a blood vessel.
摘要翻译： 一种用于小血管血栓切除手术的小型交叉血栓血栓切除术导管。 在微型交叉流血栓切除术导管的远端附近的环形成在同心对准的导流管的下管和近端定向的孔之间，其中下管中的喷射孔与环连通以引导盐水的流动 围绕和围绕环的其它流体并且从环形物向近侧引导以通过一个或多个流出孔，并且从而穿过一个或多个流入孔，从而在其间产生消融流，从而从其壁的壁上松开并携带血栓形成材料 血管
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公开(公告)号：US07572244B2
公开(公告)日：2009-08-11
申请号：US10910108
申请日：2004-08-02
IPC分类号： A61M1/00
CPC分类号： A61B17/32037 , A61B17/22 , A61B2017/22084 , Y10T29/49826
摘要： A miniature cross stream thrombectomy catheter useful in small blood vessel thrombectomy procedures. An annulus near the distal end of the miniature cross stream thrombectomy catheter is formed between a hypo-tube and a proximally directed bore of a concentrically aligned flow director whereby jet orifices in the hypo-tube communicate with the annulus to direct jet flows of saline or other fluid around and about the annulus and to be directed proximally from the annulus to pass through one or more outflow orifices and thence to pass through one or more inflow orifices thereby creating an ablation flow therebetween which loosens and carries away thrombotic materials from the walls of a blood vessel.
摘要翻译： 一种用于小血管血栓切除手术的小型交叉血栓血栓切除术导管。 在微型交叉流血栓切除术导管的远端附近的环形成在同心对准的导流管的下管和近端定向的孔之间，其中下管中的喷射孔与环连通以引导盐水的流动 围绕和围绕环的其它流体并且从环形物向近侧引导以通过一个或多个流出孔，并且从而穿过一个或多个流入孔，从而在其间产生消融流，从而从其壁的壁上松开并携带血栓形成材料 血管
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公开(公告)号：US06676637B1
公开(公告)日：2004-01-13
申请号：US09888454
申请日：2001-06-25
申请人： Michael J. Bonnette , Hieu V. Le , John Edward Morris , Stephen E. Weisel , Debra M. Kozak , Robert G. Dutcher
发明人： Michael J. Bonnette , Hieu V. Le , John Edward Morris , Stephen E. Weisel , Debra M. Kozak , Robert G. Dutcher
IPC分类号： A61M5178
CPC分类号： A61B17/32037 , A61B2090/034 , Y10T83/0443 , Y10T83/0453
摘要： A single operator exchange fluid jet thrombectomy method employing a single operator exchange fluid jet thrombectomy device having an outer catheter assembly and separable and exchangeable components in the form of an inner catheter assembly allowing functioning as a rheolytic thrombectomy catheter or as a crossflow thrombectomy catheter. The outer catheter assembly is common to any mode of usage and includes a guide catheter having a lumen through which a guidewire and the greater portion of a hypo-tube carrying a jet emanator and a flow director are passed and advanced. In the method, thrombus is dislodged, entrained, and broken into pieces by fluid jets and evacuated through the lumen of the guide catheter.
摘要翻译： 单个操作者交换流体喷射血栓切除术方法，其使用具有外部导管组件的单个操作者交换流体喷射血栓切除装置，以及允许作为溶血性血栓切除术导管或横流血栓切除术导管起作用的内部导管组件形式的可分离和可更换部件。 外导管组件对于任何使用模式都是共同的，并且包括具有内腔的引导导管，通过该导管将导丝和携带喷射发生器和导流器的下管的较大部分通过并前进。 在该方法中，通过流体射流将血栓移出，夹带并分裂成碎片，并通过引导导管的内腔排出。
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公开(公告)号：US06755803B1
公开(公告)日：2004-06-29
申请号：US09888455
申请日：2001-06-25
申请人： Hieu V. Le , Michael J. Bonnette , John Edward Morris , Stephen E. Weisel , Debra M. Kozak , Robert G. Dutcher
发明人： Hieu V. Le , Michael J. Bonnette , John Edward Morris , Stephen E. Weisel , Debra M. Kozak , Robert G. Dutcher
IPC分类号： A61B1720
CPC分类号： A61B17/32037 , A61B2090/034 , Y10T83/0443 , Y10T83/0453
摘要： A single operator exchange fluid jet thrombectomy device having an outer catheter assembly and separable and exchangeable components in the form of an inner catheter assembly allowing functioning as a rheolytic thrombectomy catheter or as a crossflow thrombectomy catheter. Embodiments include an outer catheter assembly common to any mode of usage having a guide catheter having a lumen through which a guidewire and the greater portion of a hypo-tube carrying a flow director are passed and advanced. For use as a rheolytic thrombectomy catheter, thrombus is dislodged, entrained, and broken into pieces by jets and evacuated through the lumen of the guide catheter. For use as a crossflow thrombectomy catheter, a flow director having outflow and inflow orifices is provided.
摘要翻译： 单个操作者交换流体喷射血栓切除装置，其具有外导管组件和内导管组件形式的可分离和可更换组件，其允许作为溶血性血栓切除术导管或横流血栓切除术导管。 实施例包括与任何使用模式共同的外导管组件，其具有具有内腔的引导导管，引导线和携带导流器的下管的较大部分通过该内腔通过并前进。 为了用作溶解性血栓切除术导管，血栓被移出，夹带并通过射流破碎成碎片，并通过导管的内腔排出。 为了用作横流血栓切除术导管，提供了具有流出和流入孔的导流器。
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公开(公告)号：US20130131594A1
公开(公告)日：2013-05-23
申请号：US13813221
申请日：2011-08-03
CPC分类号： A61M25/10 , A61F2/958 , A61M25/0032 , A61M25/0097 , A61M25/1002 , A61M25/1034 , A61M25/1036 , A61M25/104 , A61M2025/105 , A61M2025/1086
摘要： A balloon catheter (10) having a shaft (16), a balloon (14), and an external delivery tube (12) is disclosed. Methods of using the balloon catheter having an external delivery tube are also disclosed. In one example, the balloon catheter is an agent delivery catheter including a catheter body extending between catheter proximal and distal portions. An inflatable balloon assembly (100) is coupled with the catheter body. An agent delivery assembly (102) is coupled with the catheter body and the inflatable balloon assembly. The agent delivery assembly includes a delivery lumen (32) extending through the catheter body, and an agent delivery tube extending along an exterior balloon surface (64). The agent delivery tube includes at least one delivery orifice (70) directed outside of the exterior balloon surface. The agent delivery assembly is isolated from fluid communication with the inflatable balloon assembly.
摘要翻译： 公开了一种具有轴（16），气球（14）和外部输送管（12）的球囊导管（10）。 还公开了使用具有外部输送管的气囊导管的方法。 在一个示例中，气囊导管是包括在导管近端部分和远端部分之间延伸的导管主体的药剂输送导管。 可充气球囊组件（100）与导管主体联接。 药剂输送组件（102）与导管主体和可充气球囊组件联接。 药剂输送组件包括延伸穿过导管主体的递送腔（32）和沿外部气囊表面（64）延伸的药剂输送管。 药剂输送管包括指向外气囊表面外部的至少一个输送孔（70）。 药剂输送组件与可充气球囊组件的流体连通隔离。
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17.发明授权Rheolytic thrombectomy catheter with self-inflating proximal balloon with drug infusion capabilities 有权溶血性血栓切除术导管带有自充气近端球囊药物输注能力公开(公告)号：US08439878B2
公开(公告)日：2013-05-14
申请号：US12338376
申请日：2008-12-18
IPC分类号： A61M5/178
CPC分类号： A61B17/32037 , A61B2017/22062 , A61B2017/22065
摘要： A thrombectomy catheter with a self-inflating proximal balloon having drug infusion capabilities is described. A self-inflating balloon is formed from an inflatable thin walled section of a flexible catheter tube. The self-inflating balloon includes a plurality of outflow orifices located about the peripheral circumference thereof and located proximal to an inflow gap interposed between a fluid jet emanator and the self-inflating balloon. The self-inflating balloon is inflated and expanded by internal operating pressures by proximal composite flow of fluid from the fluid jet emanator and entrained fluid from the inflow gap to uniformly space and position the outflow orifices of the self-inflating balloon in close proximity to the thrombus or vessel walls of a blood vessel. The thrombectomy catheter may be used for, among other things, thrombectomies, embolectomies, thrombus or vessel dilation, and for the delivery of drugs to a thrombus or vessel site.
摘要翻译： 描述了具有药物输注能力的具有自充气近端球囊的血栓切除术导管。 自充气气囊由柔性导管的可膨胀薄壁部分形成。 自膨胀气囊包括多个位于其周边周围的流出孔，位于流体喷射发生器和自膨胀气囊之间的入口间隙附近。 自充气气球通过内部操作压力通过来自流体喷射发生器的流体的近似复合流动和来自流入间隙的夹带的流体膨胀和膨胀，以将自膨胀气囊的流出孔均匀地间隔并定位在紧邻 血栓或血管壁。 血栓切除术导管可以用于血栓切除术，静脉血栓栓塞，血栓或血管扩张，以及用于将药物递送至血栓或血管部位。
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公开(公告)号：US08597238B2
公开(公告)日：2013-12-03
申请号：US13453498
申请日：2012-04-23
IPC分类号： A61M37/00
CPC分类号： A61B17/32037 , A61B17/22 , A61B2017/22079 , A61B2017/22084 , A61B2217/005 , A61M25/0029 , A61M25/0032 , A61M25/0045 , A61M25/005 , A61M25/007 , A61M2025/0034 , Y10T29/49826
摘要： An enhanced cross stream mechanical thrombectomy catheter having a distal end with outflow and inflow orifices at one side for producing concentrated cross stream jet flow for selective and concentrated thrombus ablation during thrombectomy procedures. A multidirectional fluid jet emanator positioned within the distal catheter lumen comprises high velocity fluid jets which produce jet flow that is directed toward distal and proximal ends of the catheter. Jet flow directed toward the proximal end provides a region of low pressure near an inflow orifice which acts to pull thrombotic particulate from the vasculature. The invention provides for suitable distancing of high powered ablation or suction forces from the near walls of the vasculature. Cross stream flow emanating from one side of the catheter distal end urges the opposing non-orificed side of the catheter distal end toward and against the vascular wall to inhibit contact of the inflow orifice with the vascular wall.
摘要翻译： 一种增强的交叉流机械性血栓切除术导管，其具有在一侧具有流出和流入孔的远端，用于在血栓切除术过程中产生用于选择性和集中血栓消融的浓缩的交叉流射流。 定位在远侧导管内腔内的多向流体喷射发射器包括产生朝向导管的远端和近端的射流的高速流体射流。 朝向近端的喷射流提供靠近流入孔的低压区域，其用于从脉管系统拉动血栓形成的颗粒。 本发明提供从脉管系统的近壁适当地间隔大功率消融或吸力。 从导管远端的一侧发出的交叉流流动促使导管远端的相对的非引导侧朝向血管壁并抵靠血管壁，以阻止入口与血管壁接触。
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公开(公告)号：US08162877B2
公开(公告)日：2012-04-24
申请号：US12174978
申请日：2008-07-17
IPC分类号： A61M37/00
CPC分类号： A61B17/32037 , A61B17/22 , A61B2017/22079 , A61B2017/22084 , A61B2217/005 , A61M25/0029 , A61M25/0032 , A61M25/0045 , A61M25/005 , A61M25/007 , A61M2025/0034 , Y10T29/49826
摘要： An enhanced cross stream mechanical thrombectomy catheter with backloading manifold having a distal end with outflow and inflow orifices at one side for producing concentrated cross stream jet flow for selective and concentrated thrombus ablation during thrombectomy procedures. The invention provides for suitable distancing of high powered ablation or suction forces from the near walls of the vasculature. Cross stream flow emanating from the one side of the distal end of the catheter resultantly urges the distal end of the catheter and thus the opposing non-orificed side of the distal end of the catheter toward and against the vascular wall to inhibit contact of the inflow orifice with the vascular wall. Features of the invention include a geometrically configured insert to facilitate the backloading or exchange of guidewires.
摘要翻译： 具有后支管道的增强的交叉流机械性血栓切除术导管，其具有在一侧具有流出和流入孔的远端，用于在血栓切除术过程中产生用于选择性和集中血栓消融的浓缩的交叉流射流。 本发明提供从脉管系统的近壁适当地间隔大功率消融或吸力。 从导管的远端的一侧发出的交叉流流动导致导管的远端，并因此促使导管的远端的相对的未通气的侧面朝向和抵靠血管壁，以阻止流入物的接触 孔与血管壁。 本发明的特征包括几何构造的插入件，以便于引导线的后退或更换。
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20.发明申请RHEOLYTIC THROMBECTOMY CATHETER WITH SELF-INFLATING PROXIMAL BALLOON WITH DRUG INFUSION CAPABILITIES 有权具有自体浸润性气道的具有药物输注能力的流感性喉镜导管公开(公告)号：US20090171267A1
公开(公告)日：2009-07-02
申请号：US12338376
申请日：2008-12-18
IPC分类号： A61B17/22
CPC分类号： A61B17/32037 , A61B2017/22062 , A61B2017/22065
摘要： The present disclosure involves a rheolytic thrombectomy catheter with a self-inflating proximal balloon having drug infusion capabilities. A self-inflating balloon having a plurality of outflow orifices located about the peripheral circumference thereof is located proximal to an inflow gap or orifices and a fluid jet emanator and which balloon is inflated and expanded by internal operating pressures to uniformly space and position the outflow orifices of the self-inflating balloon in close proximity to or in intimate contact with the thrombus or walls of the blood vessel. Devices of the present disclosure can be used for the purposes of thrombectomies, embolectomies, thrombus or vessel dilation and for the delivery of drugs to a thrombus or vessel site.
摘要翻译： 本公开涉及具有具有药物输注能力的自充气近端球囊的溶血性血栓切除术导管。 具有围绕其周向周边定位的多个流出孔的自充气气囊位于入口间隙或孔口和流体喷射发生器附近，并且该气囊通过内部操作压力而膨胀和膨胀，以均匀地间隔和定位出口孔 的自充气球囊与血栓或血管壁紧密接触或紧密接触。 本公开的装置可以用于血栓切除术，静脉注射，血栓或血管扩张以及将药物递送至血栓或血管部位的目的。
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