公开(公告)号：US07326781B2

公开(公告)日：2008-02-05

申请号：US10412897

申请日：2003-04-11

申请人： Daniel B. Davison ,  John N. Feder ,  Liana M. Lee ,  Karl-Heinz Ott

发明人： Daniel B. Davison ,  John N. Feder ,  Liana M. Lee ,  Karl-Heinz Ott

IPC分类号： C07H21/04

CPC分类号： C12N9/1205

摘要： The present invention describes a novel human protein kinase related to citron kinase, and its encoding polynucleotide. Also described are expression vectors, host cells, antisense molecules, and antibodies associated with the protein kinase polynucleotide and/or polypeptide of this invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders or diseases associated with abnormal biological activity of the protein kinase are described, as are methods for screening for modulators, e.g., agonists or antagonists, of the protein kinase activity and/or function.

摘要翻译： 本发明描述了与柚子激酶相关的新型人蛋白激酶及其编码多核苷酸。 还描述了与本发明的蛋白激酶多核苷酸和/或多肽相关的表达载体，宿主细胞，反义分子和抗体。 此外，描述了用于治疗，诊断，预防和筛选与蛋白激酶的异常生物活性相关的疾病或疾病的方法，以及用于筛选蛋白激酶活性的调节剂例如激动剂或拮抗剂的方法和/ 或功能。

公开(公告)号：US07202056B2

公开(公告)日：2007-04-10

申请号：US10403938

申请日：2003-03-28

申请人： Liana M. Lee ,  John N. Feder ,  Shujian Wu ,  Jian Chen

发明人： Liana M. Lee ,  John N. Feder ,  Shujian Wu ,  Jian Chen

IPC分类号： C12P21/06 ,  C12N15/87 ,  C12N1/20 ,  C12N15/74 ,  C07H21/04

CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K14/70503

摘要： The present invention provides novel polynucleotides encoding BGS-19 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying the novel BGS-19 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码BGS-19多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将新型BGS-19多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。