公开(公告)号：US07767418B2

公开(公告)日：2010-08-03

申请号：US12152547

申请日：2008-05-15

申请人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Liana M. Lee ,  Michael A. Blanar

发明人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Liana M. Lee ,  Michael A. Blanar

IPC分类号： C12P21/06 ,  C12N15/00 ,  C07K1/00 ,  C07H21/02

CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码LTRPC3多肽的新型多核苷酸，其片段及其同源物。 本发明还提供了分别编码LTRPC3多肽，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f的变体和剪接变体的多核苷酸。 还提供载体，宿主细胞，以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型LTRPC3，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US07504481B2

公开(公告)日：2009-03-17

申请号：US10405793

申请日：2003-03-28

申请人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Liana M. Lee ,  Michael A. Blanar

发明人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Liana M. Lee ,  Michael A. Blanar

IPC分类号： C07K1/00 ,  C12P21/06 ,  C12P21/04 ,  C12N15/00 ,  A61K39/00

CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing the novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码LTRPC3多肽的新型多核苷酸，其片段及其同源物。 本发明还提供了分别编码LTRPC3多肽，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f的变体和剪接变体的多核苷酸。 还提供了用于产生新型LTRPC3，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f多肽的载体，宿主细胞，抗体以及重组和合成方法。 本发明还涉及将这些新型LTRPC3，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20080274505A1

公开(公告)日：2008-11-06

申请号：US12152547

申请日：2008-05-15

申请人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Liana M. Lee ,  Michael A. Blanar ,  David Bol ,  Paul C. Lavesque ,  Lucy Sun

发明人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Liana M. Lee ,  Michael A. Blanar ,  David Bol ,  Paul C. Lavesque ,  Lucy Sun

IPC分类号： C12N15/12 ,  C12N15/63 ,  C12P21/00 ,  C12N5/10

CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码LTRPC3多肽的新型多核苷酸，其片段及其同源物。 本发明还提供了分别编码LTRPC3多肽，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f的变体和剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型LTRPC3，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US07202056B2

公开(公告)日：2007-04-10

申请号：US10403938

申请日：2003-03-28

申请人： Liana M. Lee ,  John N. Feder ,  Shujian Wu ,  Jian Chen

发明人： Liana M. Lee ,  John N. Feder ,  Shujian Wu ,  Jian Chen

IPC分类号： C12P21/06 ,  C12N15/87 ,  C12N1/20 ,  C12N15/74 ,  C07H21/04

CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K14/70503

摘要： The present invention provides novel polynucleotides encoding BGS-19 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying the novel BGS-19 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码BGS-19多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将新型BGS-19多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US07223557B2

公开(公告)日：2007-05-29

申请号：US10153244

申请日：2002-05-22

申请人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Han Chang ,  Liana M. Le ,  Michael A. Blanar ,  David Bol

发明人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Han Chang ,  Liana M. Le ,  Michael A. Blanar ,  David Bol

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/02 ,  C12N5/06 ,  C07K14/705

CPC分类号： C07K14/705

摘要： The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码TRP-PLIK2多肽的新型多核苷酸，其片段和同源物。 本发明还提供分别编码TRP-PLIK2多肽，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d的变体和剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型TRP-PLIK2，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d多肽应用于诊断，治疗和/或预防与这些相关的各种疾病和/或病症的诊断和治疗方法 多肽。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20080318257A1

公开(公告)日：2008-12-25

申请号：US12220155

申请日：2008-07-22

申请人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Michael A. Blanar ,  David K. Bol ,  Paul C. Levesque ,  Lucy Sun

发明人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Michael A. Blanar ,  David K. Bol ,  Paul C. Levesque ,  Lucy Sun

IPC分类号： G01N33/53 ,  C07K16/18 ,  C12N5/06 ,  G01N33/566

CPC分类号： C07K14/705 ,  C07H21/04 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/622

摘要： The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

公开(公告)号：US07285633B2

公开(公告)日：2007-10-23

申请号：US11313356

申请日：2005-12-21

申请人： Shujian Wu ,  Jian Chen ,  John N. Feder ,  Liana Lee ,  Stanley R. Krystek

发明人： Shujian Wu ,  Jian Chen ,  John N. Feder ,  Liana Lee ,  Stanley R. Krystek

IPC分类号： A61K38/17

CPC分类号： C12N9/6489

摘要： The present invention provides novel polynucleotides encoding MMP-29 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MMP-29 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码MMP-29多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型MMP-29多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US06642041B2

公开(公告)日：2003-11-04

申请号：US10067443

申请日：2002-02-05

申请人： Jian Chen ,  John N. Feder ,  Thomas C. Nelson ,  Stanley R. Krystek ,  Franck Duclos

发明人： Jian Chen ,  John N. Feder ,  Thomas C. Nelson ,  Stanley R. Krystek ,  Franck Duclos

IPC分类号： C12N948

CPC分类号： C12N9/6489 ,  C07K2299/00

摘要： The present invention provides novel polynucleotides encoding MP-1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MP-1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码MP-1多肽，其片段和同系物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型MP-1多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20110076742A1

公开(公告)日：2011-03-31

申请号：US12903658

申请日：2010-10-13

申请人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

发明人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

IPC分类号： C07H21/00 ,  C12N15/63 ,  C12N5/10 ,  C12N9/50 ,  C07H21/04

CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2317/41 ,  C07K2317/76 ,  C12N9/6424 ,  C12Y302/01008 ,  C12Y304/21061 ,  Y10T436/143333

摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于与这些多肽相关的各种疾病和/或病症的诊断，治疗和/或预防的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US07846706B2

公开(公告)日：2010-12-07

申请号：US12456798

申请日：2009-06-23

申请人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

发明人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

IPC分类号： C12N9/00 ,  C12N9/50 ,  C12N1/20 ,  C12N15/00 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2317/41 ,  C07K2317/76 ,  C12N9/6424 ,  C12Y302/01008 ,  C12Y304/21061 ,  Y10T436/143333

摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。