Bridged carbocyclic oxime hepatitis C virus serine protease inhibitors
    11.
    发明授权
    Bridged carbocyclic oxime hepatitis C virus serine protease inhibitors 有权
    桥联碳环肟丙型肝炎病毒丝氨酸蛋白酶抑制剂

    公开(公告)号:US08283309B2

    公开(公告)日:2012-10-09

    申请号:US12338612

    申请日:2008-12-18

    IPC分类号: A61K38/00

    CPC分类号: C07D273/00

    摘要: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. More specifically, the invention relates to oxime compounds containing a carbocyclic P2 unit, and the oxime is tethered to one of the carboxylic acid on P2. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

    摘要翻译: 本发明公开了式I化合物或其药学上可接受的盐,酯或前药:其抑制丝氨酸蛋白酶活性,特别是丙型肝炎病毒(HCV)NS3-NS4A蛋白酶的活性。 因此,本发明的化合物干扰丙型肝炎病毒的生命周期,也可用作抗病毒剂。 更具体地,本发明涉及含有碳环P2单元的肟化合物,并且肟与P2上的一种羧酸结合。 本发明还涉及药物组合物,其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

    Method and System for Implementing Power Detection
    12.
    发明申请
    Method and System for Implementing Power Detection 有权
    实现功率检测的方法和系统

    公开(公告)号:US20120231748A1

    公开(公告)日:2012-09-13

    申请号:US13257785

    申请日:2010-05-17

    IPC分类号: H04B17/00 H04B1/38

    摘要: The present invention discloses a method and system for implementing power detection, wherein said method includes: extracting basic information of a destination base station from a detection request, obtaining configuration information of said destination base station from a database according to the basic information, and searching available signal transmission links and power collection points of said destination base station according to the configuration information; carrying out power collection, and analyzing power values of each available power collection point on the available signal transmission link, and updating the power values of corresponding power collection points. With the present invention, power detection can be carried out on the device from a perspective of the system, and the maintainability and operability are improved.

    摘要翻译: 本发明公开了一种用于实现功率检测的方法和系统,其中所述方法包括:从检测请求中提取目的基站的基本信息,根据基本信息从数据库获取所述目的基站的配置信息,以及搜索 可用信号传输链路和所述目的基站的电力收集点,根据配置信息; 对可用信号传输链路上的每个可用功率采集点的功率值进行集中并分析,并更新相应的功率采集点的功率值。 通过本发明,能够从系统的角度对设备进行功率检测,提高了维护性和可操作性。

    MULTI-FORMAT VIDEO DECODER AND METHODS FOR USE THEREWITH
    14.
    发明申请
    MULTI-FORMAT VIDEO DECODER AND METHODS FOR USE THEREWITH 审中-公开
    多格式视频解码器及其使用方法

    公开(公告)号:US20120230410A1

    公开(公告)日:2012-09-13

    申请号:US13076518

    申请日:2011-03-31

    IPC分类号: H04N7/12

    摘要: A multi-format video decoder includes an entropy decoding device that generates entropy decoded (EDC) data from an encoded video signal. A multi-format video decoding device includes a memory module that stores format configuration data corresponding to a plurality of video coding formats. A plurality of vector processor units generate a decoded video signal from the EDC data, wherein the plurality of vector processing units are configured, based on the configuration data, to a selected one of the plurality of video coding formats.

    摘要翻译: 多格式视频解码器包括从编码视频信号生成熵解码(EDC)数据的熵解码装置。 多格式视频解码装置包括存储对应于多个视频编码格式的格式配置数据的存储器模块。 多个向量处理器单元从EDC数据生成解码视频信号,其中,基于配置数据将多个向量处理单元配置为多个视频编码格式中选择的一个。

    Tag ranking
    15.
    发明授权
    Tag ranking 有权
    标签排名

    公开(公告)号:US08175847B2

    公开(公告)日:2012-05-08

    申请号:US12415722

    申请日:2009-03-31

    IPC分类号: G06F17/18

    CPC分类号: G06F17/30038

    摘要: Technologies for generating a boosted tag ranking for a media instance, the boosted tag ranking based on probabilistic relevance estimation computed by a probabilistic relevance estimator and tag correlation refining performed by a tag correlation refiner. Such boosted tag rankings may be used for search result ranking, tag recommendation, and group recommendation.

    摘要翻译: 用于生成用于媒体实例的提升的标签排名的技术,基于由概率相关性估计器计算的概率相关性估计的增强的标签排名以及由标签相关性精炼器执行的标签相关性精炼。 这种提升的标签排名可以用于搜索结果排名,标签推荐和组推荐。

    DIFLUOROMETHYL-CONTAINING MACROCYCLIC COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS
    16.
    发明申请
    DIFLUOROMETHYL-CONTAINING MACROCYCLIC COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS 有权
    含有大分子化合物作为丙型肝炎病毒抑制剂

    公开(公告)号:US20090274657A1

    公开(公告)日:2009-11-05

    申请号:US12433191

    申请日:2009-04-30

    摘要: The present invention discloses compounds of formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

    摘要翻译: 本发明公开了式I化合物或其药学上可接受的盐,酯或前药:其抑制丝氨酸蛋白酶活性,特别是丙型肝炎病毒(HCV)NS3-NS4A蛋白酶的活性。 因此,本发明的化合物干扰丙型肝炎病毒的生命周期,也可用作抗病毒剂。 本发明还涉及药物组合物,其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

    Use of untranslated region of osmotin gene to enhance transgene expression in plants
    17.
    发明申请
    Use of untranslated region of osmotin gene to enhance transgene expression in plants 有权
    使用非翻译区的osmotin基因来增强植物中的转基因表达

    公开(公告)号:US20090064376A1

    公开(公告)日:2009-03-05

    申请号:US12012813

    申请日:2008-02-05

    CPC分类号: C12N15/8216 C07H21/04

    摘要: The present invention provides methods, vectors and gene constructs for enhancing expression of a recombinant nucleic acid sequence in transgenic plants and plant tissues. According to the present invention, nucleic acid sequences are obtained and/or derived from the 5′ and 3′ untranslated regions of genes encoding osmotin proteins and engineered to flank respective portions of a selected coding region of a vector. The vector construct may be introduced into plants and/or plant tissues through conventional procedures, resulting in enhanced expression of the selected coding region. In a preferred embodiment, the selected coding region is a chimeric gene or gene fragment expressing one or more proteins known to impart a level of insecticidal activity to a transgenic plant and/or plant tissue.

    摘要翻译: 本发明提供用于增强转基因植物和植物组织中重组核酸序列表达的方法,载体和基因构建体。 根据本发明,获得核酸序列和/或衍生自编码osmotin蛋白的基因的5'和3'非翻译区,并被工程改造成位于载体的选定编码区的相应部分。 载体构建体可以通过常规方法引入植物和/或植物组织中,导致所选编码区的表达增强。 在优选的实施方案中,选择的编码区是表达一种或多种已知赋予转基因植物和/或植物组织杀虫活性水平的蛋白质的嵌合基因或基因片段。

    Block-Based Fast Image Compression
    18.
    发明申请
    Block-Based Fast Image Compression 有权
    基于块的快速图像压缩

    公开(公告)号:US20070201751A1

    公开(公告)日:2007-08-30

    申请号:US11276342

    申请日:2006-02-24

    IPC分类号: G06K9/36

    摘要: Systems and methods for block-based fast image compression are described. In one aspect, a digital image is segmented into multiple blocks. A respective set of statistical characteristics is identified for each of the segmented blocks. Each of the blocks is encoded with a particular encoding algorithm of multiple encoding algorithms. The particular encoding algorithm that is used to encode a particular block segmented from the digital image is selected to efficiently encode the block in view of statistical characteristics associated with the block. Thus, blocks of different block types may be encoded with different encoding algorithms.

    摘要翻译: 描述了基于块的快速图像压缩的系统和方法。 在一个方面,数字图像被分割成多个块。 针对每个分段块识别相应的一组统计特性。 每个块都用多种编码算法的特定编码算法进行编码。 选择用于编码从数字图像分割的特定块的特定编码算法,以便考虑到与块相关联的统计特性来有效地对块进行编码。 因此,不同块类型的块可以用不同的编码算法进行编码。

    System modeling facilitating method and apparatus
    19.
    发明申请
    System modeling facilitating method and apparatus 有权
    系统建模促进方法和装置

    公开(公告)号:US20060282241A1

    公开(公告)日:2006-12-14

    申请号:US11441625

    申请日:2006-05-26

    IPC分类号: G06G7/48

    CPC分类号: G06Q10/06 G06Q10/04

    摘要: A system modeling facilitating method and apparatus, wherein, entities and interactions among the entities are introduced gradually starting from critical entities in a system to form an abstract view of the entities. An associated sub-module is built for at least one of the entities and interfaces to other entities are formed for the sub-module. Representations of behaviors and logical relations among the behaviors, as well as links between its interfaces and representations of behaviors are built. When an entity is extended to be a sub-module, other entities appear in abstract form, forming a local view of sub-module together with the other entities shown in abstract form. A global view can be formed by combining the sub-modules depicted in the local view based on the interaction described in the abstract view.

    摘要翻译: 一种系统建模促进方法和装置,其中,实体之间的实体和交互从系统中的关键实体逐渐引入以形成实体的抽象视图。 为至少一个实体构建相关联的子模块,并为子模块形成与其他实体的接口。 构建了行为的行为和逻辑关系的表征,以及其界面与行为表示之间的联系。 当实体扩展为子模块时,其他实体以抽象形式出现,形成子模块的本地视图以及以抽象形式显示的其他实体。 可以通过组合基于在抽象视图中描述的交互的本地视图中描述的子模块来形成全局视图。

    Open location management device
    20.
    发明申请
    Open location management device 审中-公开
    开放位置管理装置

    公开(公告)号:US20060089159A1

    公开(公告)日:2006-04-27

    申请号:US10513722

    申请日:2003-05-09

    申请人: Dong Liu

    发明人: Dong Liu

    IPC分类号: H04Q7/20

    CPC分类号: H04W64/00

    摘要: The invention provides an open location management device, an open location management system and an open location management method, in which an open location management device receives a user location management request from a location information requester, and selects one location management provider from one or more location management providers to provide the user location information for the location information requestor. A unique user ID is assigned to each user in the system. By employing the invention, the location information requester can leverage the user location information provided by external location information providers, such that the burden of performing the location management of the location information requestor can be reduced.

    摘要翻译: 本发明提供了一种开放位置管理装置,开放位置管理系统和开放位置管理方法,其中开放位置管理装置从位置信息请求者接收用户位置管理请求,并且从一个或多个 位置管理提供商为位置信息请求者提供用户位置信息。 为系统中的每个用户分配唯一的用户ID。 通过采用本发明,位置信息请求者可以利用由外部位置信息提供者提供的用户位置信息,从而可以减少执行位置信息请求者的位置管理的负担。