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公开(公告)号：US20130017565A1
公开(公告)日：2013-01-17
申请号：US13465639
申请日：2012-05-07
申请人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
发明人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
CPC分类号： G01N33/66 , A61K31/727 , C08B37/0075 , C12P19/26 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333
摘要： The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
摘要翻译： 本发明涉及用于表征和使用多糖的方法和产品。 描述了低分子量肝素产品和使用方法。 还描述了表征包括糖胺聚糖如肝素的多糖制剂的纯度和活性的方法。
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公开(公告)号：US20100062468A1
公开(公告)日：2010-03-11
申请号：US12509774
申请日：2009-07-27
申请人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
发明人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
CPC分类号： G01N33/66 , A61K31/727 , C08B37/0075 , C12P19/26 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333
摘要： The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
摘要翻译： 本发明涉及用于表征和使用多糖的方法和产品。 描述了低分子量肝素产品和使用方法。 还描述了表征包括糖胺聚糖如肝素的多糖制剂的纯度和活性的方法。
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公开(公告)号：US08173384B2
公开(公告)日：2012-05-08
申请号：US12509774
申请日：2009-07-27
申请人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
发明人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
IPC分类号： C12Q1/56
CPC分类号： G01N33/66 , A61K31/727 , C08B37/0075 , C12P19/26 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333
摘要： The invention relates to methods and products for analyzing or processing a heparin sample. In one embodiment, the methods comprise contacting the sample with heparinase I, heparinase II and heparinase III, determining the amount of a signature component in the sample using a separation method, and making a determination about the sample based upon a comparison of the amount of the signature component in the sample to a reference database for a heparin.
摘要翻译： 本发明涉及用于分析或加工肝素样品的方法和产品。 在一个实施方案中，所述方法包括使样品与肝素酶I，肝素酶II和肝素酶III接触，使用分离方法确定样品中的特征成分的量，并且基于对样品的量 样本中的签名组件到肝素的参考数据库。
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14.发明授权Rationally designed heparinases derived from heparinase I and II and methods of sequencing therewith 有权合理设计源自肝素酶I和II的肝素酶及其测序方法公开(公告)号：US07560106B2
公开(公告)日：2009-07-14
申请号：US11191144
申请日：2005-07-27
CPC分类号： A61K38/47 , C08B37/0078 , C12N9/88 , C12N9/99
摘要： Modified heparinases having altered binding specificity and activity are provided. Isolated nucleic acids encoding the same as well as vectors and host cells are provided. Methods for using the modified heparinases are also provided.
摘要翻译： 提供具有改变的结合特异性和活性的修饰的肝素酶。 提供编码相同的分离的核酸以及载体和宿主细胞。 还提供了使用改性肝素酶的方法。
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公开(公告)号：US07399604B2
公开(公告)日：2008-07-15
申请号：US11183323
申请日：2005-07-15
申请人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
发明人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
IPC分类号： C12Q1/56
CPC分类号： G01N33/66 , A61K31/727 , C08B37/0075 , C12P19/26 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333
摘要： The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
摘要翻译： 本发明涉及用于表征和使用多糖的方法和产品。 描述了低分子量肝素产品和使用方法。 还描述了表征包括糖胺聚糖如肝素的多糖制剂的纯度和活性的方法。
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16.发明申请公开(公告)号：US20070161073A1
公开(公告)日：2007-07-12
申请号：US11606623
申请日：2006-11-30
申请人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
发明人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
IPC分类号： C12Q1/34
CPC分类号： G01N33/66 , A61K31/727 , C08B37/0075 , C12P19/26 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333
摘要： The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
摘要翻译： 本发明涉及用于表征和使用多糖的方法和产品。 描述了低分子量肝素产品和使用方法。 还描述了表征包括糖胺聚糖如肝素的多糖制剂的纯度和活性的方法。
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公开(公告)号：US20070148158A1
公开(公告)日：2007-06-28
申请号：US11643631
申请日：2006-12-20
CPC分类号： A61K38/47 , C08B37/0078 , C12N9/88 , C12N9/99
摘要： Modified heparinases having altered binding specificity and activity are provided. Isolated nucleic acids encoding the same as well as vectors and host cells are provided. Methods for using the modified heparinases are also provided.
摘要翻译： 提供具有改变的结合特异性和活性的修饰的肝素酶。 提供编码相同的分离的核酸以及载体和宿主细胞。 还提供了使用改性肝素酶的方法。
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公开(公告)号：US07687479B2
公开(公告)日：2010-03-30
申请号：US11518534
申请日：2006-09-08
申请人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
发明人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
IPC分类号： A01N43/04
CPC分类号： G01N33/66 , A61K31/727 , C08B37/0075 , C12P19/26 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333
摘要： The invention relates, in part, to methods and products related to producing low molecular weight heparin.
摘要翻译： 本发明部分涉及生产低分子量肝素的方法和产品。
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公开(公告)号：US07585642B2
公开(公告)日：2009-09-08
申请号：US11606623
申请日：2006-11-30
申请人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
发明人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
IPC分类号： C12Q1/56
CPC分类号： G01N33/66 , A61K31/727 , C08B37/0075 , C12P19/26 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333
摘要： The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
摘要翻译： 本发明涉及用于表征和使用多糖的方法和产品。 描述了低分子量肝素产品和使用方法。 还描述了表征包括糖胺聚糖如肝素的多糖制剂的纯度和活性的方法。
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20.发明申请公开(公告)号：US20070065921A1
公开(公告)日：2007-03-22
申请号：US11518534
申请日：2006-09-08
申请人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
发明人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
CPC分类号： G01N33/66 , A61K31/727 , C08B37/0075 , C12P19/26 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333
摘要： The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
摘要翻译： 本发明涉及用于表征和使用多糖的方法和产品。 描述了低分子量肝素产品和使用方法。 还描述了表征包括糖胺聚糖如肝素的多糖制剂的纯度和活性的方法。
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