公开(公告)号：US12078645B2

公开(公告)日：2024-09-03

申请号：US16073742

申请日：2017-01-25

Applicant: Hôpitaux Universitaires de Strasbourg ,  Diagnostica Stago

Inventor： Julie Helms ,  Florence Toti ,  Laure Stiel ,  Laurent Mauvieux ,  Ferhat Meziani

IPC: G01N33/53 ,  G01N15/14 ,  G01N33/50 ,  G01N33/68 ,  G01N33/86

CPC classification number: G01N33/86 ,  G01N15/14 ,  G01N33/5005 ,  G01N33/6893 ,  G01N2015/1486 ,  G01N2333/70503 ,  G01N2333/70596 ,  G01N2800/226 ,  G01N2800/26 ,  G01N2800/50 ,  G01N2800/52

Abstract: A method and kit for-, in particular, the medical and veterinary field, predicts and/or detects disseminated intravascular coagulation (DIC) in a biological sample.

公开(公告)号：US12078637B2

公开(公告)日：2024-09-03

申请号：US17203030

申请日：2021-03-16

Applicant: Medtronic Vascular, Inc.

Inventor： Charlene Yuan ,  Trevor Huang ,  Tessy Kanayinkal

IPC: G01N33/569 ,  B01L3/00 ,  G01N33/86

CPC classification number: G01N33/56966 ,  B01L3/502 ,  G01N33/86

Abstract: A method carried out by a system configured to analyze platelet aggregation includes retaining a ferromagnetic object at an elevation of a chamber in which a sample of blood or plasma is disposed. The ferromagnetic object is retained at the elevation for a period of time. The ferromagnetic object is then released from the elevation. The ferromagnetic object minimal position is measured following the release of the ferromagnetic object. The object minimal position may be correlated with amount of platelet aggregation in the sample.

公开(公告)号：US20240280593A1

公开(公告)日：2024-08-22

申请号：US18231880

申请日：2023-08-09

Applicant: Debiopharm International S.A.

Inventor： Amar Rida ,  Nicolas Mermod ,  Patrice Francoiis ,  Vladimir Lazarevic ,  Jacques Schrenzel

IPC: G01N33/86 ,  C12Q1/56 ,  G01N33/569

CPC classification number: G01N33/86 ,  C12Q1/56 ,  G01N33/56938 ,  G01N2333/75 ,  G01N2333/974

Abstract: A method for separating target molecules or particles from a fibrinogen containing sample comprises: (a) trapping the said target molecules or particles in a fibrin network by converting at least partially the fibrinogen contained in the sample into fibrin; (b) retracting the said fibrin network to form a fibrin clot; (c) separating the said fibrin clot from the surrounding sample medium.

公开(公告)号：US20240272085A1

公开(公告)日：2024-08-15

申请号：US18294454

申请日：2022-07-22

Applicant: Kommanditgesellschaft Behnk Elektronik GmbH & Co.

Inventor： Christian Radon

IPC: G01N21/82 ,  G01N21/31 ,  G01N33/86 ,  G16B50/30

CPC classification number: G01N21/82 ,  G01N21/314 ,  G01N33/86 ,  G16B50/30 ,  G01N2021/825

Abstract: What is disclosed is a method for creating a database for determining a virtual reference value for a light transmission aggregometry measurement, comprising the following steps:



a. providing platelet-rich plasma “PRP” (17) of a reference blood sample;
b. performing a light transmission measurement with a first light wavelength and a second light wavelength (14), different from the first, on the PRP (17) of the reference blood sample;
c. providing platelet-poor plasma “PPP” of the reference blood sample;
d. performing a light transmission measurement on the PPP in order to determine a PPP reference value;
e. assigning the measurement result of step d to the measurement results of step b in a database;
f. repeating steps a to e for a plurality of reference blood samples.




The database obtained using this method makes it possible to determine a virtual reference value that is an excellent estimate of the PPP reference value. Once the database has been created, it is possible to determine virtual reference values of blood samples to be examined and perform LTA measurements using the virtual reference values, without the need to obtain PPP from the blood samples to be examined.

公开(公告)号：US12031993B2

公开(公告)日：2024-07-09

申请号：US16708334

申请日：2019-12-09

Applicant: CA CASYSO GmbH

Inventor： Michael M. Gorin ,  Robert S. Hillman ,  Cory Lee McCluskey ,  Hubert Martin Schwaiger

IPC: G01N33/86 ,  G01N33/49

CPC classification number: G01N33/86 ,  G01N33/4905

Abstract: Some embodiments of a blood coagulation testing system include an analyzer console device and a single-use cartridge component configured to releasably install into the console device. In some embodiments, the blood coagulation testing system can operate as an automated thromboelastometry system that is particularly useful, for example, at a point-of-care site.

公开(公告)号：US11903970B2

公开(公告)日：2024-02-20

申请号：US17132634

申请日：2020-12-23

Applicant: Regenexx, LLC

Inventor： Christopher J. Centeno ,  Neven Steinmetz ,  Ian Stemper ,  Dustin Berger

IPC: C12M1/00 ,  A61K35/19 ,  C12N5/078 ,  A61K45/06 ,  C12N5/00 ,  G01N33/86 ,  C12M1/42

CPC classification number: A61K35/19 ,  A61K45/06 ,  C12M47/06 ,  C12N5/0018 ,  C12N5/0644 ,  C12M35/04 ,  C12N2523/00 ,  G01N33/86

Abstract: Apparatus, kit and method embodiments are disclosed herein that provide for the production of a modified autologous platelet mixture at a patient bedside for contemporaneous reinjection to the patient using a platelet lysis apparatus. Representative platelet lysis apparatus may include a housing supporting a sample tube and a thermal mass element connected to or near the sample tube. The thermal mass element may be separable from the housing, and/or the sample tube may be separable from the thermal mass element.

公开(公告)号：US20240027478A1

公开(公告)日：2024-01-25

申请号：US18256199

申请日：2021-12-06

Applicant: Genzyme Corporation

Inventor： Stacey Poloskey ,  Shauna Andersson ,  Pratik R. Bhagunde ,  Yue Cui ,  Sajida Iqbal ,  Baisong Mei

IPC: G01N33/86 ,  A61K31/713 ,  A61P7/04

CPC classification number: G01N33/86 ,  A61K31/713 ,  A61P7/04 ,  G01N2333/8128 ,  G01N2800/224 ,  G01N2800/52

Abstract: The present disclosure provides a method that aims to maintain a favorable benefit-risk balance for patients with hemophilia A or B with or without inhibitors treated with fitusiran.

公开(公告)号：US11879899B2

公开(公告)日：2024-01-23

申请号：US17393036

申请日：2021-08-03

Applicant: C A Casyso GmbH

Inventor： Axel Schubert ,  Jose J. Romero-Galeano ,  Max Kessler

IPC: G01N33/86 ,  B01L3/00 ,  G01N11/00 ,  G01N11/14 ,  G01N33/49

CPC classification number: G01N33/86 ,  B01L3/502 ,  B01L3/52 ,  G01N11/00 ,  G01N11/14 ,  G01N33/4905 ,  B01L2200/10 ,  B01L2300/0627 ,  B01L2300/0636 ,  B01L2300/087 ,  B01L2300/0861 ,  B01L2400/0475 ,  G01N2011/0046 ,  G01N2333/96458 ,  G01N2800/224

Abstract: The present invention is directed to a cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, in particular a blood sample, comprising a cartridge body having at least one measurement cavity formed therein and having at least one probe element arranged in said at least one measurement cavity for performing a test on said sample liquid; and a cover being attachable on said cartridge body; wherein said cover covers at least partially said at least one measurement cavity and forms a retaining element for retaining said probe element in a predetermined position within said at least one measurement cavity. The invention is directed to a measurement system and a method for measuring viscoelastic characteristics of a sample liquid.

公开(公告)号：US11872555B2

公开(公告)日：2024-01-16

申请号：US16973780

申请日：2019-03-21

Applicant: LANSION BIOTECHNOLOGY CO., LTD

Inventor： Xingshang Xu ,  Jeffery Chen

IPC: B01L3/00 ,  G01N33/86 ,  B01L7/00 ,  G01N33/49

CPC classification number: B01L3/502715 ,  B01L7/00 ,  G01N33/4905 ,  G01N33/86 ,  B01L2200/087 ,  B01L2300/023 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/18

Abstract: A detection system for multi-index coagulation items, including a housing, a detection and heating module, a battery module, a touch display screen and a mainboard. The housing includes an upper housing and a lower housing, and is an enclosed space formed by the upper housing abutting the lower housing; the mainboard is disposed between the upper and the lower housing, and is arranged in the enclosed space; the touch display screen is disposed at the upper surface of upper housing, and is connected with the mainboard; the detection and heating module is disposed in the enclosed space, and is arranged at the front end of lower housing for connecting with the mainboard; the battery module is arranged at the bottom of terminal of lower housing, and is connected with the mainboard; and a detection inlet for inserting and placing a detection card is disposed at the front end of housing.

公开(公告)号：US11850589B2

公开(公告)日：2023-12-26

申请号：US17848523

申请日：2022-06-24

Applicant: The Brigham and Women's Hospital, Inc. ,  President and Fellows of Harvard College ,  Vilnius University

Inventor： Joseph Italiano ,  Linas Mazutis ,  Jonathan N. Thon ,  David A. Weitz

IPC: B01L3/00 ,  G01N33/86 ,  C12M1/00 ,  C12M1/12 ,  C12M1/34 ,  C12M3/06 ,  G01N33/49

CPC classification number: B01L3/502753 ,  B01L3/502746 ,  B01L3/502776 ,  C12M23/16 ,  C12M23/20 ,  C12M25/02 ,  C12M29/04 ,  C12M29/10 ,  C12M29/20 ,  C12M41/36 ,  C12M41/40 ,  G01N33/86 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2400/086 ,  G01N33/491 ,  G01N2800/222 ,  Y10T436/25375

Abstract: A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.